SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lgq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WU8_C_ADNC502_1
(HYPOTHETICAL PROTEIN
PH0463)		 4lgq PUTATIVE POLYKETIDE
CYCLASE
(Chromobacterium
violaceum) 		4 / 7 PHE A  56
ASN A  22
HIS A  61
VAL A  69
 None
 1.24A 1wu8A-4lgqA:
undetectable
1wu8C-4lgqA:
undetectable		 1wu8A-4lgqA:
20.40
1wu8C-4lgqA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_E_9PLE1_1
(CYTOCHROME P450 2A13)		 4lgq PUTATIVE POLYKETIDE
CYCLASE
(Chromobacterium
violaceum) 		4 / 8 PHE A  15
ALA A  29
PHE A  52
ALA A  53
 None
 1.02A 3t3sE-4lgqA:
undetectable		 3t3sE-4lgqA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 4lgq PUTATIVE POLYKETIDE
CYCLASE
(Chromobacterium
violaceum) 		4 / 5 PHE A  36
PRO A  34
VAL A  32
ALA A 121
 None
 1.17A 4w5oA-4lgqA:
undetectable		 4w5oA-4lgqA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 4lgq PUTATIVE POLYKETIDE
CYCLASE
(Chromobacterium
violaceum) 		4 / 5 PHE A  36
PRO A  34
VAL A  32
ALA A 121
 None
 1.21A 4z4cA-4lgqA:
undetectable		 4z4cA-4lgqA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4lgq PUTATIVE POLYKETIDE
CYCLASE
(Chromobacterium
violaceum) 		4 / 5 PHE A  36
PRO A  34
VAL A  32
ALA A 121
 None
 1.18A 4z4dA-4lgqA:
undetectable		 4z4dA-4lgqA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 4lgq PUTATIVE POLYKETIDE
CYCLASE
(Chromobacterium
violaceum) 		4 / 5 PHE A  36
PRO A  34
VAL A  32
ALA A 121
 None
 1.16A 4z4eA-4lgqA:
undetectable		 4z4eA-4lgqA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 4lgq PUTATIVE POLYKETIDE
CYCLASE
(Chromobacterium
violaceum) 		4 / 6 PHE A  36
PRO A  34
VAL A  32
ALA A 121
 None
 1.17A 5t7bA-4lgqA:
undetectable		 5t7bA-4lgqA:
10.44