SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lgv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HMY_A_SAMA328_0
(HAEIII
METHYLTRANSFERASE)		 4lgv GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE
(Mycobacterium
avium) 		4 / 8 ASP A  89
THR A  91
PRO A 116
LEU A 119
 None
 0.61A 1hmyA-4lgvA:
5.9		 1hmyA-4lgvA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 4lgv GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE
(Mycobacterium
avium) 		5 / 12 LEU A  21
LEU A 113
ALA A 139
LEU A 110
LEU A  30
 None
 1.22A 1s9pB-4lgvA:
undetectable		 1s9pB-4lgvA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 4lgv GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE
(Mycobacterium
avium) 		5 / 12 LEU A 113
ALA A 139
LEU A 110
VAL A  13
LEU A  30
 None
 1.28A 1s9pB-4lgvA:
undetectable		 1s9pB-4lgvA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA702_0
(FERROCHELATASE)		 4lgv GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE
(Mycobacterium
avium) 		4 / 7 LEU A 162
PRO A 117
VAL A 140
MET A 115
 None
 1.19A 2hrcA-4lgvA:
2.1		 2hrcA-4lgvA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 4lgv GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE
(Mycobacterium
avium) 		3 / 3 VAL A 170
ASP A 171
GLU A 141
 None
 0.74A 2qeuA-4lgvA:
undetectable		 2qeuA-4lgvA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_C_ACTC141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 4lgv GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE
(Mycobacterium
avium) 		3 / 3 VAL A 170
ASP A 171
GLU A 141
 None
 0.71A 2qeuC-4lgvA:
undetectable		 2qeuC-4lgvA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA509_0
(CHORISMATE SYNTHASE)		 4lgv GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE
(Mycobacterium
avium) 		3 / 3 ARG A 317
GLN A 458
PRO A 459
 None
 0.89A 2qhfA-4lgvA:
undetectable		 2qhfA-4lgvA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 4lgv GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE
(Mycobacterium
avium) 		5 / 11 LEU A 182
VAL A 242
LEU A 333
VAL A 329
ILE A 204
 None
 1.16A 2uxoB-4lgvA:
undetectable		 2uxoB-4lgvA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 4lgv GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE
(Mycobacterium
avium) 		5 / 12 LEU A 316
ILE A 314
ILE A 204
ILE A 206
MET A 266
 None
 0.99A 2ygoA-4lgvA:
undetectable		 2ygoA-4lgvA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 4lgv GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE
(Mycobacterium
avium) 		3 / 3 TRP A 441
VAL A 230
ARG A 228
 None
 0.85A 3b0wA-4lgvA:
undetectable		 3b0wA-4lgvA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		 4lgv GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE
(Mycobacterium
avium) 		4 / 7 SER A 107
VAL A  13
TYR A 111
ILE A 103
 None
 1.23A 3bu1A-4lgvA:
undetectable		 3bu1A-4lgvA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_B_NIOB5661_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 4lgv GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE
(Mycobacterium
avium) 		4 / 8 ILE A  17
ALA A  22
LEU A  30
ALA A  63
 None
 0.95A 3hrdA-4lgvA:
undetectable
3hrdB-4lgvA:
undetectable		 3hrdA-4lgvA:
22.91
3hrdB-4lgvA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_1
(PROTEASE)		 4lgv GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE
(Mycobacterium
avium) 		5 / 9 GLY A  88
ASP A  49
ILE A  51
GLY A  45
ILE A  44
 None
 0.98A 3s53A-4lgvA:
undetectable		 3s53A-4lgvA:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_B_URFB1301_1
(URIDINE
PHOSPHORYLASE)		 4lgv GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE
(Mycobacterium
avium) 		4 / 7 GLY A 104
ARG A 135
ILE A 103
PRO A 109
 None
 1.07A 4e1vB-4lgvA:
undetectable		 4e1vB-4lgvA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_A_NCTA501_1
(CYTOCHROME P450 2A13)		 4lgv GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE
(Mycobacterium
avium) 		4 / 7 ASN A 256
ALA A 415
THR A 419
LEU A 174
 None
 1.09A 4ejgA-4lgvA:
undetectable		 4ejgA-4lgvA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4lgv GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE
(Mycobacterium
avium) 		5 / 12 ILE A  44
LEU A  95
ILE A 123
ASN A 126
LEU A 127
 None
 0.98A 4gh8A-4lgvA:
undetectable		 4gh8A-4lgvA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 4lgv GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE
(Mycobacterium
avium) 		3 / 3 ASN A 190
PHE A 187
TYR A 184
 None
 0.85A 4u15A-4lgvA:
undetectable		 4u15A-4lgvA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_2
(ESTROGEN RECEPTOR)		 4lgv GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE
(Mycobacterium
avium) 		4 / 5 LEU A 110
GLU A 114
LEU A  33
HIS A  41
 None
 1.33A 4xi3B-4lgvA:
undetectable		 4xi3B-4lgvA:
17.92