SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lh7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1434_1
(CHITINASE)		 4lh7 DNA LIGASE
(Enterococcus
faecalis) 		3 / 3 TRP A 310
THR A 228
TYR A 227
 None
None
1X8  A 401 (-3.6A)
 1.18A 2a3aA-4lh7A:
undetectable		 2a3aA-4lh7A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_B_TEPB2434_1
(CHITINASE)		 4lh7 DNA LIGASE
(Enterococcus
faecalis) 		3 / 3 TRP A 310
THR A 228
TYR A 227
 None
None
1X8  A 401 (-3.6A)
 1.18A 2a3aB-4lh7A:
undetectable		 2a3aB-4lh7A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_A_CFFA1434_1
(CHITINASE)		 4lh7 DNA LIGASE
(Enterococcus
faecalis) 		3 / 3 TRP A 310
THR A 228
TYR A 227
 None
None
1X8  A 401 (-3.6A)
 1.19A 2a3bA-4lh7A:
undetectable		 2a3bA-4lh7A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_F_RBFF204_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)		 4lh7 DNA LIGASE
(Enterococcus
faecalis) 		4 / 8 ASN A 153
ARG A 210
GLU A 148
VAL A 217
 None
 1.12A 2fl5E-4lh7A:
undetectable
2fl5F-4lh7A:
undetectable		 2fl5E-4lh7A:
23.82
2fl5F-4lh7A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD36_0
(GCN4 LEUCINE ZIPPER)		 4lh7 DNA LIGASE
(Enterococcus
faecalis) 		3 / 3 SER A  26
TYR A  29
HIS A  27
 NMN  A 402 (-4.4A)
NMN  A 402 (-3.5A)
None
 0.82A 2r2vD-4lh7A:
undetectable		 2r2vD-4lh7A:
8.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4lh7 DNA LIGASE
(Enterococcus
faecalis) 		4 / 8 GLY A 233
ILE A 168
VAL A 170
VAL A 229
 None
 0.74A 3fi0B-4lh7A:
undetectable		 3fi0B-4lh7A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_G_TRPG1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4lh7 DNA LIGASE
(Enterococcus
faecalis) 		4 / 8 GLY A 233
ILE A 168
VAL A 170
VAL A 229
 None
 0.64A 3fi0G-4lh7A:
undetectable		 3fi0G-4lh7A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_Q_TRPQ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4lh7 DNA LIGASE
(Enterococcus
faecalis) 		4 / 8 GLY A 233
ILE A 168
VAL A 170
VAL A 229
 None
 0.73A 3fi0Q-4lh7A:
undetectable		 3fi0Q-4lh7A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWU_A_ADNA501_1
(DNA LIGASE)		 4lh7 DNA LIGASE
(Enterococcus
faecalis) 		5 / 12 GLU A 118
LYS A 120
GLU A 175
VAL A 289
LYS A 291
 1X8  A 401 (-3.4A)
1X8  A 401 (-3.6A)
1X8  A 401 (-3.6A)
1X8  A 401 ( 4.3A)
1X8  A 401 (-2.7A)
 0.58A 3qwuA-4lh7A:
9.9		 3qwuA-4lh7A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWU_A_ADNA501_1
(DNA LIGASE)		 4lh7 DNA LIGASE
(Enterococcus
faecalis) 		5 / 12 TYR A  87
GLU A 118
LYS A 120
VAL A 289
LYS A 291
 1X8  A 401 (-4.4A)
1X8  A 401 (-3.4A)
1X8  A 401 (-3.6A)
1X8  A 401 ( 4.3A)
1X8  A 401 (-2.7A)
 0.94A 3qwuA-4lh7A:
9.9		 3qwuA-4lh7A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWU_B_ADNB501_1
(DNA LIGASE)		 4lh7 DNA LIGASE
(Enterococcus
faecalis) 		5 / 11 GLU A 118
LYS A 120
GLU A 175
VAL A 289
LYS A 291
 1X8  A 401 (-3.4A)
1X8  A 401 (-3.6A)
1X8  A 401 (-3.6A)
1X8  A 401 ( 4.3A)
1X8  A 401 (-2.7A)
 0.55A 3qwuB-4lh7A:
10.7		 3qwuB-4lh7A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWU_B_ADNB501_1
(DNA LIGASE)		 4lh7 DNA LIGASE
(Enterococcus
faecalis) 		5 / 11 TYR A  87
GLU A 118
LYS A 120
VAL A 289
LYS A 291
 1X8  A 401 (-4.4A)
1X8  A 401 (-3.4A)
1X8  A 401 (-3.6A)
1X8  A 401 ( 4.3A)
1X8  A 401 (-2.7A)
 1.12A 3qwuB-4lh7A:
10.7		 3qwuB-4lh7A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 4lh7 DNA LIGASE
(Enterococcus
faecalis) 		4 / 4 LEU A  89
ILE A 285
TYR A 314
TYR A 227
 1X8  A 401 (-4.0A)
None
None
1X8  A 401 (-3.6A)
 1.41A 3vt7A-4lh7A:
1.3		 3vt7A-4lh7A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4lh7 DNA LIGASE
(Enterococcus
faecalis) 		4 / 4 PRO A   5
LEU A   6
ILE A  52
ARG A  14
 None
 1.39A 3w1wA-4lh7A:
undetectable		 3w1wA-4lh7A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_B_ECNB403_1
(FLAVOHEMOGLOBIN)		 4lh7 DNA LIGASE
(Enterococcus
faecalis) 		5 / 11 ILE A 126
LEU A 154
THR A 156
VAL A 157
LEU A 209
 None
 1.01A 4g1bB-4lh7A:
3.5		 4g1bB-4lh7A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_D_ECND403_1
(FLAVOHEMOGLOBIN)		 4lh7 DNA LIGASE
(Enterococcus
faecalis) 		5 / 12 ILE A 126
LEU A 154
THR A 156
VAL A 157
LEU A 209
 None
 1.03A 4g1bD-4lh7A:
undetectable		 4g1bD-4lh7A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 4lh7 DNA LIGASE
(Enterococcus
faecalis) 		3 / 3 TYR A  42
ARG A 158
SER A  26
 NMN  A 402 (-3.4A)
NMN  A 402 (-3.7A)
NMN  A 402 (-4.4A)
 0.89A 4khpI-4lh7A:
undetectable
4khpJ-4lh7A:
undetectable		 4khpI-4lh7A:
18.67
4khpJ-4lh7A:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 4lh7 DNA LIGASE
(Enterococcus
faecalis) 		5 / 12 PHE A 232
ALA A 237
GLN A 240
LYS A 291
LEU A 247
 None
None
None
1X8  A 401 (-2.7A)
None
 1.48A 4qztC-4lh7A:
undetectable		 4qztC-4lh7A:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4lh7 DNA LIGASE
(Enterococcus
faecalis) 		3 / 3 ARG A 104
PHE A 303
PHE A 101
 None
 1.08A 6nknC-4lh7A:
undetectable
6nknJ-4lh7A:
undetectable		 6nknC-4lh7A:
19.47
6nknJ-4lh7A:
12.50