SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lhe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_A_BEZA295_0
(CHLOROPEROXIDASE T)		 4lhe THERMOSTABLE
MONOACYLGLYCEROL
LIPASE
(Bacillus
sp.
H-257) 		5 / 10 GLY A  28
PHE A  29
SER A  97
MET A  98
HIS A 226
 SO4  A 302 (-3.6A)
None
SO4  A 302 (-2.7A)
None
SO4  A 302 (-3.9A)
 0.68A 1a8uA-4lheA:
21.4		 1a8uA-4lheA:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_B_BEZB294_0
(CHLOROPEROXIDASE T)		 4lhe THERMOSTABLE
MONOACYLGLYCEROL
LIPASE
(Bacillus
sp.
H-257) 		5 / 10 GLY A  28
PHE A  29
SER A  97
MET A  98
HIS A 226
 SO4  A 302 (-3.6A)
None
SO4  A 302 (-2.7A)
None
SO4  A 302 (-3.9A)
 0.68A 1a8uB-4lheA:
21.4		 1a8uB-4lheA:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LBD_A_9CRA424_1
(RETINOIC ACID
RECEPTOR GAMMA)		 4lhe THERMOSTABLE
MONOACYLGLYCEROL
LIPASE
(Bacillus
sp.
H-257) 		5 / 12 ALA A 188
ILE A 113
GLY A  95
ALA A 121
ILE A 190
 None
 1.25A 3lbdA-4lheA:
undetectable		 3lbdA-4lheA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_A_CAMA423_0
(CYTOCHROME P450)		 4lhe THERMOSTABLE
MONOACYLGLYCEROL
LIPASE
(Bacillus
sp.
H-257) 		5 / 9 THR A 162
LEU A 167
LEU A 170
VAL A 198
VAL A 199
 None
 1.40A 4c9pA-4lheA:
undetectable		 4c9pA-4lheA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_B_HFGB1602_1
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 4lhe THERMOSTABLE
MONOACYLGLYCEROL
LIPASE
(Bacillus
sp.
H-257) 		4 / 5 HIS A  27
THR A  30
GLU A 156
HIS A 226
 None
SO4  A 302 (-2.9A)
None
SO4  A 302 (-3.9A)
 1.20A 4hvcB-4lheA:
3.7		 4hvcB-4lheA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K87_A_ADNA602_1
(PROLINE--TRNA LIGASE)		 4lhe THERMOSTABLE
MONOACYLGLYCEROL
LIPASE
(Bacillus
sp.
H-257) 		4 / 8 ARG A  37
GLY A  95
THR A  94
THR A 229
 None
 0.98A 4k87A-4lheA:
3.2		 4k87A-4lheA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFJ_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 4lhe THERMOSTABLE
MONOACYLGLYCEROL
LIPASE
(Bacillus
sp.
H-257) 		6 / 12 ALA A 249
PHE A 244
ARG A 240
PHE A 245
PRO A 118
VAL A  23
 None
 1.47A 4kfjB-4lheA:
undetectable		 4kfjB-4lheA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4lhe THERMOSTABLE
MONOACYLGLYCEROL
LIPASE
(Bacillus
sp.
H-257) 		4 / 8 ALA A  42
ASP A 233
ILE A 237
ILE A 119
 None
 0.86A 4kttD-4lheA:
undetectable		 4kttD-4lheA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_2
(ADENOSINE KINASE)		 4lhe THERMOSTABLE
MONOACYLGLYCEROL
LIPASE
(Bacillus
sp.
H-257) 		4 / 5 ASN A 151
LEU A 149
SER A 224
ASN A 120
 None
 0.96A 4n09C-4lheA:
5.4		 4n09C-4lheA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4lhe THERMOSTABLE
MONOACYLGLYCEROL
LIPASE
(Bacillus
sp.
H-257) 		3 / 3 ASN A 223
ASP A 231
ASP A 153
 None
 0.77A 4obwD-4lheA:
undetectable		 4obwD-4lheA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_H_TR6H101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 4lhe THERMOSTABLE
MONOACYLGLYCEROL
LIPASE
(Bacillus
sp.
H-257) 		3 / 5 GLY A 131
GLY A 134
GLU A 137
 None
 0.43A 4z2eA-4lheA:
undetectable
4z2eD-4lheA:
3.1		 4z2eA-4lheA:
18.20
4z2eD-4lheA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		 4lhe THERMOSTABLE
MONOACYLGLYCEROL
LIPASE
(Bacillus
sp.
H-257) 		4 / 6 TYR A 159
THR A  60
ARG A  54
GLY A  31
 None
None
None
CL  A 301 ( 3.9A)
 1.10A 5mraA-4lheA:
undetectable
5mraB-4lheA:
undetectable		 5mraA-4lheA:
20.97
5mraB-4lheA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NN4_A_SC2A1016_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 4lhe THERMOSTABLE
MONOACYLGLYCEROL
LIPASE
(Bacillus
sp.
H-257) 		4 / 4 HIS A  27
GLY A  59
ARG A  54
THR A  60
 None
 1.47A 5nn4A-4lheA:
1.8		 5nn4A-4lheA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_A_ADNA401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 4lhe THERMOSTABLE
MONOACYLGLYCEROL
LIPASE
(Bacillus
sp.
H-257) 		5 / 12 GLY A 210
ILE A 206
LEU A 181
ALA A 179
LEU A 104
 None
 1.03A 6bq4A-4lheA:
2.1		 6bq4A-4lheA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		 4lhe THERMOSTABLE
MONOACYLGLYCEROL
LIPASE
(Bacillus
sp.
H-257) 		5 / 12 GLY A  99
GLY A  95
LEU A  96
GLY A  57
GLU A   3
 None
None
SO4  A 302 ( 4.9A)
None
None
 0.94A 6gngB-4lheA:
5.8		 6gngB-4lheA:
18.82