SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lhq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_A_ACTA601_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 4lhq CAMELID NANOBODY
(Vicugna
pacos) 		4 / 7 SER B  56
ALA B  55
SER B  54
SER B  57
 None
 0.99A 2i91A-4lhqB:
undetectable		 2i91A-4lhqB:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_B_ACTB602_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 4lhq CAMELID NANOBODY
(Vicugna
pacos) 		4 / 7 SER B  56
ALA B  55
SER B  54
SER B  57
 None
 0.99A 2i91B-4lhqB:
undetectable		 2i91B-4lhqB:
13.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 4lhq CAMELID NANOBODY
(Vicugna
pacos) 		5 / 12 ALA B  24
SER B  28
MET B  34
ARG B  72
VAL B  79
 None
 0.91A 3qxtA-4lhqB:
21.6		 3qxtA-4lhqB:
64.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 4lhq CAMELID NANOBODY
(Vicugna
pacos) 		6 / 12 LEU B   4
ALA B  24
SER B  28
MET B  34
ARG B  72
VAL B  79
 None
 0.76A 3qxtB-4lhqB:
22.0		 3qxtB-4lhqB:
64.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4lhq CAMELID NANOBODY
(Vicugna
pacos) 		6 / 12 ALA B  24
SER B  28
MET B  34
ARG B  72
ASN B  74
VAL B  79
 None
 0.87A 3qxvA-4lhqB:
21.7		 3qxvA-4lhqB:
63.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4lhq CAMELID NANOBODY
(Vicugna
pacos) 		5 / 12 ALA B  24
SER B  28
MET B  34
ARG B  72
VAL B  79
 None
 0.90A 3qxvB-4lhqB:
21.6		 3qxvB-4lhqB:
63.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_C_MTXC2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4lhq CAMELID NANOBODY
(Vicugna
pacos) 		5 / 11 SER B  28
MET B  34
ARG B  72
ASN B  74
VAL B  79
 None
 0.64A 3qxvC-4lhqB:
22.0		 3qxvC-4lhqB:
63.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_D_MTXD2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4lhq CAMELID NANOBODY
(Vicugna
pacos) 		5 / 12 ALA B  24
SER B  28
MET B  34
ARG B  72
VAL B  79
 None
 0.83A 3qxvD-4lhqB:
21.5		 3qxvD-4lhqB:
63.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_E_MTXE2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4lhq CAMELID NANOBODY
(Vicugna
pacos) 		6 / 12 CYH B  22
ALA B  24
SER B  28
MET B  34
ARG B  72
VAL B  79
 None
 0.94A 3qxvE-4lhqB:
18.3		 3qxvE-4lhqB:
63.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_2
(TUBULIN BETA-2B
CHAIN)		 4lhq CAMELID NANOBODY
(Vicugna
pacos) 		5 / 12 CYH B  22
LEU B   4
ALA B  24
ASN B  32
ILE B  51
 None
 0.86A 4o2bB-4lhqB:
undetectable		 4o2bB-4lhqB:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_2
(TUBULIN BETA-2B
CHAIN)		 4lhq CAMELID NANOBODY
(Vicugna
pacos) 		5 / 12 CYH B  22
LEU B   4
ALA B  24
ASN B  32
ILE B  51
 None
 0.86A 4o2bD-4lhqB:
undetectable		 4o2bD-4lhqB:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_B_LOCB502_1
(TUBULIN BETA CHAIN)		 4lhq CAMELID NANOBODY
(Vicugna
pacos) 		5 / 12 CYH B  22
LEU B   4
ALA B  24
ASN B  32
ILE B  51
 None
 0.75A 4x1yB-4lhqB:
undetectable		 4x1yB-4lhqB:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_B_LOCB502_1
(TUBULIN BETA CHAIN)		 4lhq CAMELID NANOBODY
(Vicugna
pacos) 		5 / 12 CYH B  22
LEU B   4
ALA B  24
ASN B  32
ILE B  51
 None
 0.73A 4x20B-4lhqB:
undetectable		 4x20B-4lhqB:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_B_LOCB504_2
(TUBULIN BETA CHAIN)		 4lhq CAMELID NANOBODY
(Vicugna
pacos) 		5 / 12 CYH B  22
LEU B   4
ALA B  24
ASN B  32
ILE B  51
 None
 0.83A 5xiwB-4lhqB:
undetectable		 5xiwB-4lhqB:
20.77