SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lhs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_A_URFA999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 4lhs UNCHARACTERIZED
PROTEIN
(Bacteroides
ovatus) 		4 / 5 ALA A 353
TYR A 350
ILE A 354
ASP A 243
 None
 1.22A 1upfA-4lhsA:
undetectable		 1upfA-4lhsA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_C_URFC999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 4lhs UNCHARACTERIZED
PROTEIN
(Bacteroides
ovatus) 		4 / 5 ALA A 353
TYR A 350
ILE A 354
ASP A 243
 None
 1.14A 1upfC-4lhsA:
3.1		 1upfC-4lhsA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2003_1
(SERUM ALBUMIN)		 4lhs UNCHARACTERIZED
PROTEIN
(Bacteroides
ovatus) 		5 / 10 LEU A 157
PHE A  50
LEU A 109
LEU A 149
ILE A  77
 None
 1.00A 2bxeB-4lhsA:
undetectable		 2bxeB-4lhsA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_P1ZA2002_1
(SERUM ALBUMIN)		 4lhs UNCHARACTERIZED
PROTEIN
(Bacteroides
ovatus) 		5 / 12 LEU A 157
PHE A  50
LEU A 109
LEU A 149
ILE A  77
 None
 1.03A 2bxqA-4lhsA:
undetectable		 2bxqA-4lhsA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBP_A_SAMA300_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 4lhs UNCHARACTERIZED
PROTEIN
(Bacteroides
ovatus) 		5 / 12 GLY A 198
GLY A 191
SER A 219
LEU A 101
LEU A  98
 None
None
PEG  A 400 ( 4.3A)
None
None
 0.86A 2zbpA-4lhsA:
undetectable		 2zbpA-4lhsA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		 4lhs UNCHARACTERIZED
PROTEIN
(Bacteroides
ovatus) 		3 / 3 ASP A 340
PHE A 343
LEU A 347
 None
 0.32A 2zi9A-4lhsA:
2.8		 2zi9A-4lhsA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMF_A_SAMA388_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4lhs UNCHARACTERIZED
PROTEIN
(Bacteroides
ovatus) 		5 / 12 TYR A 350
GLY A 191
ASP A 243
PRO A 338
PHE A 343
 None
 1.03A 3dmfA-4lhsA:
undetectable		 3dmfA-4lhsA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG801_0
(GLUTAMATE RECEPTOR 2)		 4lhs UNCHARACTERIZED
PROTEIN
(Bacteroides
ovatus) 		3 / 3 PRO A  84
SER A 165
ASN A  82
 None
 0.75A 3lslG-4lhsA:
undetectable		 3lslG-4lhsA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 4lhs UNCHARACTERIZED
PROTEIN
(Bacteroides
ovatus) 		4 / 7 PHE A 343
LEU A 153
ASP A 340
VAL A 333
 None
 1.01A 4cp4A-4lhsA:
undetectable		 4cp4A-4lhsA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_A_FOLA301_1
(FOLATE RECEPTOR
ALPHA)		 4lhs UNCHARACTERIZED
PROTEIN
(Bacteroides
ovatus) 		3 / 3 ASP A 138
TRP A  90
SER A  83
 None
 1.06A 4lrhA-4lhsA:
undetectable		 4lrhA-4lhsA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_A_BRLA501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4lhs UNCHARACTERIZED
PROTEIN
(Bacteroides
ovatus) 		4 / 5 GLY A 217
ILE A 214
LEU A  75
LEU A 101
 None
 0.88A 4o8fA-4lhsA:
undetectable		 4o8fA-4lhsA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDR_A_ADNA402_1
(FAD:PROTEIN FMN
TRANSFERASE)		 4lhs UNCHARACTERIZED
PROTEIN
(Bacteroides
ovatus) 		5 / 12 VAL A 124
ASP A 110
ILE A 126
PRO A 127
THR A 102
 None
 1.01A 4xdrA-4lhsA:
undetectable		 4xdrA-4lhsA:
21.16