SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lhu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_K_BEZK4387_0
(CES1 PROTEIN)		 4lhu 9C2 TCR DELTA CHAIN
(Homo
sapiens) 		3 / 3 TRP D  32
LEU D  96
LYS D   5
 None
 1.44A 1yajK-4lhuD:
undetectable		 1yajK-4lhuD:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OLD_B_IPHB2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 4lhu 9C2 TCR GAMMA CHAIN
(Homo
sapiens) 		4 / 7 TYR G  39
HIS G  41
PRO G  47
TYR G  97
 None
 0.53A 2oldA-4lhuG:
17.7
2oldB-4lhuG:
13.8		 2oldA-4lhuG:
29.64
2oldB-4lhuG:
29.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OMB_A_IPHA2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 4lhu 9C2 TCR DELTA CHAIN
9C2 TCR GAMMA CHAIN
(Homo
sapiens;
Homo
sapiens) 		4 / 5 HIS G  41
PRO G  47
TYR G  97
TYR D  40
 None
 1.06A 2ombA-4lhuG:
17.7
2ombB-4lhuG:
13.6		 2ombA-4lhuG:
29.64
2ombB-4lhuG:
29.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OMB_D_IPHD2002_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 4lhu 9C2 TCR DELTA CHAIN
9C2 TCR GAMMA CHAIN
(Homo
sapiens;
Homo
sapiens) 		5 / 7 TYR D  40
TYR G  39
HIS G  41
PRO G  47
TYR G  97
 None
 1.05A 2ombC-4lhuD:
7.6
2ombD-4lhuD:
13.6		 2ombC-4lhuD:
31.20
2ombD-4lhuD:
31.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OMB_D_IPHD2002_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 4lhu 9C2 TCR DELTA CHAIN
9C2 TCR GAMMA CHAIN
(Homo
sapiens;
Homo
sapiens) 		4 / 7 TYR G  39
HIS G  41
PRO G  47
TYR D  40
 None
 1.21A 2ombC-4lhuG:
11.0
2ombD-4lhuG:
13.6		 2ombC-4lhuG:
29.64
2ombD-4lhuG:
29.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCD_A_RAPA138_1
(OUTER MEMBRANE
PROTEIN MIP)		 4lhu 9C2 TCR DELTA CHAIN
9C2 TCR GAMMA CHAIN
(Homo
sapiens) 		5 / 11 ASP D 164
GLN G 182
VAL D 168
ILE D 167
VAL D 193
 None
 1.38A 2vcdA-4lhuD:
undetectable		 2vcdA-4lhuD:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W1B_A_DXCA2034_0
(ACRIFLAVIN
RESISTANCE PROTEIN B)		 4lhu 9C2 TCR GAMMA CHAIN
(Homo
sapiens) 		3 / 3 PHE G 229
SER G 197
LEU G 157
 None
 0.79A 2w1bA-4lhuG:
undetectable		 2w1bA-4lhuG:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_G_CPFG1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 4lhu 9C2 TCR DELTA CHAIN
9C2 TCR GAMMA CHAIN
(Homo
sapiens) 		3 / 3 ARG G 103
GLY G 104
SER D  63
 CL  G 301 ( 3.6A)
None
None
 0.48A 2xctB-4lhuG:
undetectable		 2xctB-4lhuG:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_B_RBFB191_1
(LUMAZINE PROTEIN)		 4lhu 9C2 TCR GAMMA CHAIN
(Homo
sapiens) 		5 / 12 SER G  93
LEU G 121
THR G 120
ASN G  91
ILE G  89
 None
 1.21A 3a35B-4lhuG:
undetectable		 3a35B-4lhuG:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3B_A_RBFA191_1
(LUMAZINE PROTEIN)		 4lhu 9C2 TCR GAMMA CHAIN
(Homo
sapiens) 		5 / 12 SER G  93
LEU G 121
THR G 120
ASN G  91
ILE G  89
 None
 1.23A 3a3bA-4lhuG:
undetectable		 3a3bA-4lhuG:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6R_B_CRNB603_1
(CREATINE KINASE
B-TYPE)		 4lhu 9C2 TCR GAMMA CHAIN
(Homo
sapiens) 		4 / 6 VAL G 201
LEU G 179
GLU G 172
SER G 205
 None
 0.97A 3b6rB-4lhuG:
undetectable		 3b6rB-4lhuG:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D9L_A_ACTA501_0
(CTD-PEPTIDE
RNA-BINDING PROTEIN
16)		 4lhu 9C2 TCR GAMMA CHAIN
(Homo
sapiens) 		4 / 5 PRO G 231
ILE G 232
PRO G 141
TYR G 154
 None
 1.18A 3d9lA-4lhuG:
undetectable
3d9lY-4lhuG:
undetectable		 3d9lA-4lhuG:
20.39
3d9lY-4lhuG:
7.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_2
(PROTEASE)		 4lhu 9C2 TCR DELTA CHAIN
(Homo
sapiens) 		6 / 9 LEU D  84
ASP D  88
ILE D  52
GLY D  64
ALA D  21
ILE D  81
 None
 1.41A 3el0B-4lhuD:
undetectable		 3el0B-4lhuD:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB201_1
(PROTEIN S100-A4)		 4lhu 9C2 TCR DELTA CHAIN
9C2 TCR GAMMA CHAIN
(Homo
sapiens) 		4 / 8 GLY G 118
ILE D  49
PHE D  38
PHE D 109
 None
 0.86A 3ko0B-4lhuG:
undetectable
3ko0J-4lhuG:
undetectable		 3ko0B-4lhuG:
18.43
3ko0J-4lhuG:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_C_AG2C1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 4lhu 9C2 TCR DELTA CHAIN
9C2 TCR GAMMA CHAIN
(Homo
sapiens) 		4 / 8 HIS G  37
TRP D  32
ASP D 105
ASP D  98
 None
 1.26A 3n2oC-4lhuG:
undetectable
3n2oD-4lhuG:
undetectable		 3n2oC-4lhuG:
17.67
3n2oD-4lhuG:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_1
(FIV PROTEASE)		 4lhu 9C2 TCR GAMMA CHAIN
(Homo
sapiens) 		5 / 10 LEU G  62
ASP G  60
ILE G  36
ILE G  84
LEU G  51
 None
 0.97A 3ogpA-4lhuG:
undetectable		 3ogpA-4lhuG:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_A_DR7A100_2
(HIV-1 PROTEASE)		 4lhu 9C2 TCR DELTA CHAIN
(Homo
sapiens) 		5 / 11 LEU D  84
ASP D  88
ILE D  52
GLY D  64
ILE D  81
 None
 1.30A 3oxxB-4lhuD:
undetectable		 3oxxB-4lhuD:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4lhu 9C2 TCR GAMMA CHAIN
(Homo
sapiens) 		3 / 3 HIS G  74
SER G  21
GLU G  23
 None
 0.73A 3s8pA-4lhuG:
undetectable		 3s8pA-4lhuG:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4lhu 9C2 TCR DELTA CHAIN
9C2 TCR GAMMA CHAIN
(Homo
sapiens) 		4 / 7 PHE D  38
TYR D  40
TYR G  39
HIS G  37
 None
 1.01A 4g5jA-4lhuD:
undetectable		 4g5jA-4lhuD:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		 4lhu 9C2 TCR GAMMA CHAIN
(Homo
sapiens) 		5 / 9 THR G  73
LEU G  83
LEU G  66
GLN G  48
TYR G  39
 None
 1.44A 4ltwA-4lhuG:
undetectable		 4ltwA-4lhuG:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 4lhu 9C2 TCR GAMMA CHAIN
(Homo
sapiens) 		4 / 5 GLY G 152
THR G 200
GLN G 149
THR G 146
 None
 1.20A 5h5fA-4lhuG:
undetectable		 5h5fA-4lhuG:
22.14