SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4li2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		 4li2 LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4
(Xenopus
tropicalis) 		4 / 5 LEU A 240
LEU A 235
SER A 249
LEU A 250
 None
 1.05A 1a4lC-4li2A:
undetectable		 1a4lC-4li2A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		 4li2 LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4
(Xenopus
tropicalis) 		3 / 3 ASP A 150
PHE A 152
VAL A 147
 None
 0.69A 1kijB-4li2A:
undetectable		 1kijB-4li2A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TBF_A_VIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4li2 LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4
(Xenopus
tropicalis) 		5 / 9 LEU A 235
LEU A 219
VAL A 171
LEU A 185
PHE A 224
 None
 1.16A 1tbfA-4li2A:
undetectable		 1tbfA-4li2A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN)		 4li2 LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4
(Xenopus
tropicalis) 		5 / 11 LEU A 370
ASN A 402
ILE A 380
LEU A 361
PHE A 388
 None
 1.38A 1tw4A-4li2A:
undetectable		 1tw4A-4li2A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_C_TFPC208_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4li2 LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4
(Xenopus
tropicalis) 		4 / 5 PHE A 341
LEU A 370
PHE A 315
SER A 354
 None
 0.89A 1wrlC-4li2A:
undetectable		 1wrlC-4li2A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4li2 LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4
(Xenopus
tropicalis) 		5 / 12 VAL A 123
LEU A 187
LEU A 176
PHE A 152
LEU A 158
 None
 1.15A 2oipA-4li2A:
undetectable		 2oipA-4li2A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4li2 LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4
(Xenopus
tropicalis) 		5 / 12 VAL A 123
LEU A 187
LEU A 176
PHE A 152
LEU A 158
 None
 1.12A 2oipC-4li2A:
undetectable		 2oipC-4li2A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4li2 LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4
(Xenopus
tropicalis) 		5 / 12 LEU A 176
PHE A 200
LEU A 182
ILE A 192
SER A 136
 None
 1.25A 2po7B-4li2A:
undetectable		 2po7B-4li2A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA801_1
(TRANSPORTER)		 4li2 LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4
(Xenopus
tropicalis) 		5 / 11 LEU A 137
LEU A 113
ARG A 138
ALA A  92
ASP A 140
 None
 1.20A 2q72A-4li2A:
undetectable		 2q72A-4li2A:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_B_ADNB2_1
(YTAA PROTEIN)		 4li2 LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4
(Xenopus
tropicalis) 		4 / 6 ILE A  72
PRO A 124
LEU A 104
ILE A  99
 None
 0.99A 2q83B-4li2A:
undetectable		 2q83B-4li2A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6R_B_CRNB603_1
(CREATINE KINASE
B-TYPE)		 4li2 LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4
(Xenopus
tropicalis) 		4 / 6 THR A 122
VAL A 123
GLU A 126
SER A 151
 None
 1.20A 3b6rB-4li2A:
undetectable		 3b6rB-4li2A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 4li2 LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4
(Xenopus
tropicalis) 		4 / 7 LEU A 287
GLN A 296
LEU A 324
LEU A 329
 None
 0.93A 3g8iA-4li2A:
undetectable		 3g8iA-4li2A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4li2 LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4
(Xenopus
tropicalis) 		5 / 12 VAL A 123
LEU A 187
LEU A 176
PHE A 152
LEU A 158
 None
 1.11A 3hj3C-4li2A:
undetectable		 3hj3C-4li2A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_2
(ANDROGEN RECEPTOR)		 4li2 LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4
(Xenopus
tropicalis) 		4 / 6 LEU A 250
ASN A 274
LEU A 235
ILE A 280
 None
 1.06A 4okxA-4li2A:
undetectable		 4okxA-4li2A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB306_1
(CHITOSANASE)		 4li2 LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4
(Xenopus
tropicalis) 		4 / 5 ARG A 307
THR A 330
THR A 328
ASP A 352
 None
 1.20A 4qwpB-4li2A:
undetectable		 4qwpB-4li2A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 2)		 4li2 LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4
(Xenopus
tropicalis) 		3 / 3 PHE A 315
THR A 387
LEU A 351
 None
 0.70A 4qztA-4li2A:
undetectable		 4qztA-4li2A:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4li2 LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4
R-SPONDIN-1
(Homo
sapiens;
Xenopus
tropicalis) 		4 / 5 PRO B  89
HIS A 210
LEU A 240
TYR A 283
 None
 1.39A 5igjA-4li2B:
undetectable		 5igjA-4li2B:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4li2 LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4
(Xenopus
tropicalis) 		4 / 6 ASP A 234
HIS A 212
ILE A 216
TYR A 283
 None
 1.21A 5ih0A-4li2A:
undetectable		 5ih0A-4li2A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 4li2 LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4
(Xenopus
tropicalis) 		5 / 12 LEU A 209
LEU A 250
PRO A 251
SER A 249
PHE A 224
 None
 1.21A 5ljcA-4li2A:
undetectable		 5ljcA-4li2A:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		 4li2 LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4
(Xenopus
tropicalis) 		5 / 12 LEU A 203
LEU A 227
ILE A 195
SER A 223
ALA A 199
 None
 1.29A 6n91A-4li2A:
undetectable		 6n91A-4li2A:
14.04