SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lih'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 4lih GAMMA-GLUTAMYL-GAMMA
-AMINOBUTYRALDEHYDE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 ALA A 342
ILE A 171
THR A 199
PHE A 379
LEU A 104
 None
 1.34A 1eiiA-4lihA:
undetectable		 1eiiA-4lihA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_A_TEIA3006_1
(XANTHINE
DEHYDROGENASE)		 4lih GAMMA-GLUTAMYL-GAMMA
-AMINOBUTYRALDEHYDE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 LEU A 307
PHE A 294
THR A 367
VAL A 366
ALA A 324
 None
 1.21A 1n5xA-4lihA:
undetectable		 1n5xA-4lihA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_B_TEIB4006_1
(XANTHINE
DEHYDROGENASE)		 4lih GAMMA-GLUTAMYL-GAMMA
-AMINOBUTYRALDEHYDE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 LEU A 307
PHE A 294
THR A 367
VAL A 366
ALA A 324
 None
 1.21A 1n5xB-4lihA:
undetectable		 1n5xB-4lihA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPO_H_TESH1010_1
(ANTI-TESTOSTERONE
(HEAVY CHAIN)
ANTI-TESTOSTERONE
(LIGHT CHAIN))		 4lih GAMMA-GLUTAMYL-GAMMA
-AMINOBUTYRALDEHYDE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 SER A 271
ALA A 447
GLY A 448
LEU A 426
PHE A 465
 None
None
None
None
MES  A 501 ( 4.9A)
 1.32A 1vpoH-4lihA:
undetectable
1vpoL-4lihA:
undetectable		 1vpoH-4lihA:
17.30
1vpoL-4lihA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_F_SPMF1433_1
(NITROALKANE OXIDASE)		 4lih GAMMA-GLUTAMYL-GAMMA
-AMINOBUTYRALDEHYDE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 11 LEU A  16
GLU A 100
LEU A  98
SER A 102
LEU A 104
 None
 1.34A 2c12F-4lihA:
1.4		 2c12F-4lihA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCF_A_ESTA596_1
(ESTROGEN RECEPTOR)		 4lih GAMMA-GLUTAMYL-GAMMA
-AMINOBUTYRALDEHYDE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 10 ALA A 210
GLU A 209
LEU A  93
MET A  94
ARG A 202
 None
 1.49A 2ocfA-4lihA:
undetectable		 2ocfA-4lihA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X08_A_ASCA1253_0
(CYTOCHROME C
PEROXIDASE,
MITOCHONDRIAL)		 4lih GAMMA-GLUTAMYL-GAMMA
-AMINOBUTYRALDEHYDE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 9 ALA A 204
ILE A 201
PRO A 221
VAL A 220
ASN A 218
 None
 1.23A 2x08A-4lihA:
undetectable		 2x08A-4lihA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZB8_A_IMNA800_1
(PROSTAGLANDIN
REDUCTASE 2)		 4lih GAMMA-GLUTAMYL-GAMMA
-AMINOBUTYRALDEHYDE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 9 THR A 116
PHE A 379
TYR A 380
LEU A  48
VAL A  40
 None
 1.34A 2zb8A-4lihA:
0.0		 2zb8A-4lihA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_1
(UNCHARACTERIZED
PROTEIN MJ1557)		 4lih GAMMA-GLUTAMYL-GAMMA
-AMINOBUTYRALDEHYDE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		3 / 3 MET A  94
GLU A 105
ASN A 168
 None
None
MES  A 501 (-3.6A)
 0.89A 3a27A-4lihA:
undetectable		 3a27A-4lihA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB501_2
(PHOSPHOLIPASE A2)		 4lih GAMMA-GLUTAMYL-GAMMA
-AMINOBUTYRALDEHYDE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 11 VAL A 430
LYS A 270
SER A 271
PRO A 272
SER A 305
 None
 1.31A 3bjwB-4lihA:
undetectable		 3bjwB-4lihA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE503_1
(PHOSPHOLIPASE A2)		 4lih GAMMA-GLUTAMYL-GAMMA
-AMINOBUTYRALDEHYDE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 11 VAL A 430
LYS A 270
SER A 271
PRO A 272
SER A 305
 None
 1.35A 3bjwE-4lihA:
undetectable		 3bjwE-4lihA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH504_3
(PHOSPHOLIPASE A2)		 4lih GAMMA-GLUTAMYL-GAMMA
-AMINOBUTYRALDEHYDE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 11 VAL A 430
LYS A 270
SER A 271
PRO A 272
SER A 305
 None
 1.28A 3bjwH-4lihA:
undetectable		 3bjwH-4lihA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LUS_B_X8ZB1001_1
(ORGANIC
HYDROPEROXIDE
RESISTANCE PROTEIN)		 4lih GAMMA-GLUTAMYL-GAMMA
-AMINOBUTYRALDEHYDE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 9 ASN A 373
ALA A 374
PRO A 333
PRO A 330
PHE A 379
 None
 1.17A 3lusA-4lihA:
0.8
3lusB-4lihA:
0.0		 3lusA-4lihA:
15.48
3lusB-4lihA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4lih GAMMA-GLUTAMYL-GAMMA
-AMINOBUTYRALDEHYDE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 ALA A 240
ILE A 251
LEU A 267
GLY A 243
TYR A 424
 None
 1.20A 3nrrA-4lihA:
undetectable		 3nrrA-4lihA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4lih GAMMA-GLUTAMYL-GAMMA
-AMINOBUTYRALDEHYDE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 ALA A 240
ILE A 251
LEU A 267
GLY A 243
TYR A 424
 None
 1.18A 3nrrB-4lihA:
undetectable		 3nrrB-4lihA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 4lih GAMMA-GLUTAMYL-GAMMA
-AMINOBUTYRALDEHYDE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		4 / 6 TYR A 485
VAL A  86
VAL A 128
ILE A 135
 None
 1.10A 3pyyA-4lihA:
undetectable		 3pyyA-4lihA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_A_SALA404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 4lih GAMMA-GLUTAMYL-GAMMA
-AMINOBUTYRALDEHYDE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		4 / 7 ASN A 218
ALA A  66
ALA A  61
ARG A  29
 None
 1.03A 3twpA-4lihA:
3.3		 3twpA-4lihA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_B_SALB404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 4lih GAMMA-GLUTAMYL-GAMMA
-AMINOBUTYRALDEHYDE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		4 / 7 ASN A 218
ALA A  66
ALA A  61
ARG A  29
 None
 1.02A 3twpB-4lihA:
0.0		 3twpB-4lihA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_C_SALC404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 4lih GAMMA-GLUTAMYL-GAMMA
-AMINOBUTYRALDEHYDE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		4 / 7 ASN A 218
ALA A  66
ALA A  61
ARG A  29
 None
 1.01A 3twpC-4lihA:
3.7		 3twpC-4lihA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4lih GAMMA-GLUTAMYL-GAMMA
-AMINOBUTYRALDEHYDE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		4 / 8 LEU A 404
VAL A 366
VAL A 388
LEU A 321
 None
 1.04A 3v81C-4lihA:
undetectable		 3v81C-4lihA:
21.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FR8_A_TNGA601_1
(ALDEHYDE
DEHYDROGENASE,
MITOCHONDRIAL)		 4lih GAMMA-GLUTAMYL-GAMMA
-AMINOBUTYRALDEHYDE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		6 / 11 ASN A 168
PHE A 169
LEU A 172
MET A 173
TRP A 176
CYH A 301
 MES  A 501 (-3.6A)
MES  A 501 (-3.8A)
None
MES  A 501 ( 4.1A)
None
MES  A 501 (-3.7A)
 0.52A 4fr8A-4lihA:
58.1		 4fr8A-4lihA:
43.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FR8_A_TNGA601_1
(ALDEHYDE
DEHYDROGENASE,
MITOCHONDRIAL)		 4lih GAMMA-GLUTAMYL-GAMMA
-AMINOBUTYRALDEHYDE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		6 / 11 ASN A 168
PHE A 169
MET A 173
TRP A 176
CYH A 301
ASP A 456
 MES  A 501 (-3.6A)
MES  A 501 (-3.8A)
MES  A 501 ( 4.1A)
None
MES  A 501 (-3.7A)
MES  A 501 (-2.9A)
 0.92A 4fr8A-4lihA:
58.1		 4fr8A-4lihA:
43.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4lih GAMMA-GLUTAMYL-GAMMA
-AMINOBUTYRALDEHYDE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		3 / 3 ASP A 235
VAL A 161
ASN A  60
 None
 0.76A 4lmnA-4lihA:
undetectable		 4lmnA-4lihA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 4lih GAMMA-GLUTAMYL-GAMMA
-AMINOBUTYRALDEHYDE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		4 / 8 LEU A 404
VAL A 366
VAL A 388
LEU A 321
 None
 1.07A 4pwdC-4lihA:
undetectable		 4pwdC-4lihA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA602_1
(SERUM ALBUMIN)		 4lih GAMMA-GLUTAMYL-GAMMA
-AMINOBUTYRALDEHYDE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 PHE A 465
TYR A 455
GLY A 466
SER A 471
SER A 305
 MES  A 501 ( 4.9A)
None
None
None
None
 1.42A 4zbrA-4lihA:
undetectable		 4zbrA-4lihA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4lih GAMMA-GLUTAMYL-GAMMA
-AMINOBUTYRALDEHYDE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		4 / 7 ALA A  61
ASP A  30
ARG A  21
GLU A  19
 None
 0.92A 5btgA-4lihA:
undetectable
5btgC-4lihA:
undetectable
5btgD-4lihA:
2.1		 5btgA-4lihA:
23.50
5btgC-4lihA:
23.50
5btgD-4lihA:
21.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FHZ_A_REAA602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 4lih GAMMA-GLUTAMYL-GAMMA
-AMINOBUTYRALDEHYDE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 ASN A 168
PHE A 169
LEU A 172
MET A 173
CYH A 301
 MES  A 501 (-3.6A)
MES  A 501 (-3.8A)
None
MES  A 501 ( 4.1A)
MES  A 501 (-3.7A)
 0.88A 5fhzA-4lihA:
58.1		 5fhzA-4lihA:
39.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FHZ_A_REAA602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 4lih GAMMA-GLUTAMYL-GAMMA
-AMINOBUTYRALDEHYDE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		7 / 12 GLY A 123
ASN A 168
PHE A 169
LEU A 172
MET A 173
TRP A 176
THR A 302
 None
MES  A 501 (-3.6A)
MES  A 501 (-3.8A)
None
MES  A 501 ( 4.1A)
None
MES  A 501 (-3.0A)
 0.69A 5fhzA-4lihA:
58.1		 5fhzA-4lihA:
39.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FHZ_D_READ602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 4lih GAMMA-GLUTAMYL-GAMMA
-AMINOBUTYRALDEHYDE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 GLY A 123
ASN A 168
MET A 173
TRP A 176
THR A 302
 None
MES  A 501 (-3.6A)
MES  A 501 ( 4.1A)
None
MES  A 501 (-3.0A)
 0.74A 5fhzD-4lihA:
56.0		 5fhzD-4lihA:
39.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FHZ_D_READ602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 4lih GAMMA-GLUTAMYL-GAMMA
-AMINOBUTYRALDEHYDE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 GLY A 123
MET A 173
TRP A 176
GLU A 266
THR A 302
 None
MES  A 501 ( 4.1A)
None
None
MES  A 501 (-3.0A)
 1.23A 5fhzD-4lihA:
56.0		 5fhzD-4lihA:
39.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4lih GAMMA-GLUTAMYL-GAMMA
-AMINOBUTYRALDEHYDE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 GLY A 185
VAL A 188
PHE A 217
ALA A 132
VAL A  86
 None
 1.21A 5n0rA-4lihA:
undetectable		 5n0rA-4lihA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4lih GAMMA-GLUTAMYL-GAMMA
-AMINOBUTYRALDEHYDE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		4 / 4 GLY A 291
ALA A 325
MET A 340
THR A 367
 None
 1.00A 5n0sB-4lihA:
undetectable		 5n0sB-4lihA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4lih GAMMA-GLUTAMYL-GAMMA
-AMINOBUTYRALDEHYDE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		4 / 7 VAL A 236
ILE A 239
VAL A 189
ALA A 162
 None
 0.75A 5osrA-4lihA:
undetectable		 5osrA-4lihA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CI6_A_NBOA606_1
(SERUM ALBUMIN)		 4lih GAMMA-GLUTAMYL-GAMMA
-AMINOBUTYRALDEHYDE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 PHE A 465
TYR A 455
GLY A 466
SER A 471
SER A 305
 MES  A 501 ( 4.9A)
None
None
None
None
 1.36A 6ci6A-4lihA:
undetectable		 6ci6A-4lihA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA812_0
(GEPHYRIN)		 4lih GAMMA-GLUTAMYL-GAMMA
-AMINOBUTYRALDEHYDE
DEHYDROGENASE
(Burkholderia
cenocepacia) 		4 / 6 GLU A 105
LYS A 111
VAL A 344
PRO A  42
 None
 1.48A 6fgdA-4lihA:
3.5		 6fgdA-4lihA:
23.58