SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lik'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P9G_A_ACTA42_0
(EAFP 2)		 4lik DNA PRIMASE SMALL
SUBUNIT
(Homo
sapiens) 		3 / 3 CYH A 122
ARG A 119
CYH A 128
 ZN  A 501 (-2.2A)
None
ZN  A 501 (-2.0A)
 1.38A 1p9gA-4likA:
undetectable		 1p9gA-4likA:
5.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7F_A_NIOA601_1
(NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE)		 4lik DNA PRIMASE SMALL
SUBUNIT
(Homo
sapiens) 		4 / 6 SER A 351
GLY A 328
THR A 327
ARG A 329
 None
 1.18A 2f7fA-4likA:
undetectable		 2f7fA-4likA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1001_0
(ALDEHYDE
DEHYDROGENASE A)		 4lik DNA PRIMASE SMALL
SUBUNIT
(Homo
sapiens) 		4 / 7 LEU A 189
PHE A 108
ILE A 185
PHE A 152
 None
 0.93A 2opxA-4likA:
undetectable		 2opxA-4likA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA802_1
(PROSTAGLANDIN
REDUCTASE 1)		 4lik DNA PRIMASE SMALL
SUBUNIT
(Homo
sapiens) 		4 / 7 VAL A 118
TYR A 115
GLY A 195
VAL A 192
 None
 0.84A 2y05A-4likA:
undetectable
2y05B-4likA:
undetectable		 2y05A-4likA:
20.34
2y05B-4likA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_2
(HIV-1 PROTEASE)		 4lik DNA PRIMASE SMALL
SUBUNIT
(Homo
sapiens) 		5 / 9 LEU A 336
GLY A 164
ILE A 110
VAL A 339
ILE A 334
 None
 0.87A 3d1yB-4likA:
undetectable		 3d1yB-4likA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5P_A_TACA7101_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 4lik DNA PRIMASE SMALL
SUBUNIT
(Homo
sapiens) 		5 / 12 PRO A 344
VAL A 347
TYR A 391
ILE A 127
ILE A 334
 None
 1.27A 3q5pA-4likA:
undetectable		 3q5pA-4likA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5R_A_KANA2002_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 4lik DNA PRIMASE SMALL
SUBUNIT
(Homo
sapiens) 		5 / 11 PRO A 344
VAL A 347
TYR A 391
ILE A 127
ILE A 334
 None
 1.22A 3q5rA-4likA:
undetectable		 3q5rA-4likA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB323_0
(INVASIN IPAD)		 4lik DNA PRIMASE SMALL
SUBUNIT
(Homo
sapiens) 		4 / 7 ILE A 142
VAL A 186
LEU A 189
SER A 190
 None
 0.40A 3r9vA-4likA:
undetectable
3r9vB-4likA:
undetectable		 3r9vA-4likA:
22.58
3r9vB-4likA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQE_B_017B101_1
(ASPARTYL PROTEASE)		 4lik DNA PRIMASE SMALL
SUBUNIT
(Homo
sapiens) 		5 / 11 LEU A 336
GLY A 164
ILE A 110
VAL A 339
ILE A 334
 None
 0.96A 4dqeA-4likA:
undetectable		 4dqeA-4likA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4lik DNA PRIMASE SMALL
SUBUNIT
(Homo
sapiens) 		4 / 7 PHE A  21
TYR A  16
ILE A 353
PRO A  22
 None
 1.13A 4g5jA-4likA:
undetectable		 4g5jA-4likA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4lik DNA PRIMASE SMALL
SUBUNIT
(Homo
sapiens) 		3 / 3 ASP A 232
VAL A 118
ASN A 236
 None
 0.62A 4lmnA-4likA:
0.6		 4lmnA-4likA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA305_0
(THAUMATIN-1)		 4lik DNA PRIMASE SMALL
SUBUNIT
(Homo
sapiens) 		4 / 5 LYS A 176
GLU A 103
ILE A  36
VAL A  35
 None
 1.46A 4tvtA-4likA:
undetectable		 4tvtA-4likA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_1
(PROTEASE PR5-DRV)		 4lik DNA PRIMASE SMALL
SUBUNIT
(Homo
sapiens) 		5 / 10 LEU A 336
GLY A 164
ILE A 110
VAL A 339
ILE A 334
 None
 0.95A 5kr1A-4likA:
undetectable		 5kr1A-4likA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_2
(PROTEASE PR5-SQV)		 4lik DNA PRIMASE SMALL
SUBUNIT
(Homo
sapiens) 		5 / 9 LEU A 336
GLY A 164
ILE A 110
VAL A 339
ILE A 334
 None
 0.86A 5kr2D-4likA:
undetectable		 5kr2D-4likA:
12.02