SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lis'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4001_1
(SERUM ALBUMIN)		 4lis UDP-GLUCOSE
4-EPIMERASE
(Aspergillus
nidulans) 		4 / 5 ARG A 312
ALA A 249
ASP A 241
GLY A 247
 IOD  A 405 (-3.7A)
UPG  A 401 (-3.2A)
None
None
 0.94A 1e7bA-4lisA:
undetectable		 1e7bA-4lisA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4001_1
(SERUM ALBUMIN)		 4lis UDP-GLUCOSE
4-EPIMERASE
(Aspergillus
nidulans) 		4 / 5 ARG A 312
ALA A 249
ASP A 241
GLY A 247
 IOD  A 405 (-3.7A)
UPG  A 401 (-3.2A)
None
None
 0.94A 1e7cA-4lisA:
undetectable		 1e7cA-4lisA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ESW_A_ACRA652_1
(AMYLOMALTASE)		 4lis UDP-GLUCOSE
4-EPIMERASE
(Aspergillus
nidulans) 		4 / 6 GLY A  10
ASP A  34
TYR A  37
SER A  17
 NAD  A 402 ( 3.8A)
NAD  A 402 (-2.5A)
None
None
 0.93A 1eswA-4lisA:
2.3		 1eswA-4lisA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_A_BEZA1162_0
(PEROXIREDOXIN 5)		 4lis UDP-GLUCOSE
4-EPIMERASE
(Aspergillus
nidulans) 		5 / 10 THR A 153
PRO A 152
GLY A 151
LEU A 320
ARG A 137
 None
 1.30A 1h4oA-4lisA:
undetectable
1h4oB-4lisA:
undetectable		 1h4oA-4lisA:
19.73
1h4oB-4lisA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_D_BEZD1162_0
(PEROXIREDOXIN 5)		 4lis UDP-GLUCOSE
4-EPIMERASE
(Aspergillus
nidulans) 		5 / 9 THR A 153
PRO A 152
GLY A 151
LEU A 320
ARG A 137
 None
 1.29A 1h4oD-4lisA:
undetectable		 1h4oD-4lisA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_F_BEZF1162_0
(PEROXIREDOXIN 5)		 4lis UDP-GLUCOSE
4-EPIMERASE
(Aspergillus
nidulans) 		5 / 9 THR A 153
PRO A 152
GLY A 151
LEU A 320
ARG A 137
 None
 1.31A 1h4oF-4lisA:
undetectable		 1h4oF-4lisA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_H_BEZH1162_0
(PEROXIREDOXIN 5)		 4lis UDP-GLUCOSE
4-EPIMERASE
(Aspergillus
nidulans) 		5 / 9 THR A 153
PRO A 152
GLY A 151
LEU A 320
ARG A 137
 None
 1.33A 1h4oH-4lisA:
undetectable		 1h4oH-4lisA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HD2_A_BEZA201_0
(PEROXIREDOXIN 5
RESIDUES 54-214)		 4lis UDP-GLUCOSE
4-EPIMERASE
(Aspergillus
nidulans) 		5 / 9 THR A 153
PRO A 152
GLY A 151
LEU A 320
ARG A 137
 None
 1.30A 1hd2A-4lisA:
undetectable		 1hd2A-4lisA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OC3_B_BEZB201_0
(PEROXIREDOXIN 5)		 4lis UDP-GLUCOSE
4-EPIMERASE
(Aspergillus
nidulans) 		5 / 9 THR A 153
PRO A 152
GLY A 151
LEU A 320
ARG A 137
 None
 1.31A 1oc3B-4lisA:
undetectable		 1oc3B-4lisA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAY_A_ADNA1001_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 4lis UDP-GLUCOSE
4-EPIMERASE
(Aspergillus
nidulans) 		6 / 11 GLY A  10
ASP A  34
ASP A  61
VAL A  62
ALA A  85
VAL A 103
 NAD  A 402 ( 3.8A)
NAD  A 402 (-2.5A)
NAD  A 402 (-3.1A)
NAD  A 402 (-3.8A)
NAD  A 402 (-3.9A)
NAD  A 402 ( 4.5A)
 0.44A 1uayA-4lisA:
17.5		 1uayA-4lisA:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAY_B_ADNB1002_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 4lis UDP-GLUCOSE
4-EPIMERASE
(Aspergillus
nidulans) 		6 / 10 GLY A  10
ASP A  34
ASP A  61
VAL A  62
ALA A  85
VAL A 103
 NAD  A 402 ( 3.8A)
NAD  A 402 (-2.5A)
NAD  A 402 (-3.1A)
NAD  A 402 (-3.8A)
NAD  A 402 (-3.9A)
NAD  A 402 ( 4.5A)
 0.46A 1uayB-4lisA:
17.5		 1uayB-4lisA:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4lis UDP-GLUCOSE
4-EPIMERASE
(Aspergillus
nidulans) 		4 / 7 VAL A 170
PHE A 125
HIS A  83
THR A 108
 IOD  A 406 ( 4.9A)
None
None
None
 1.10A 2f78A-4lisA:
undetectable		 2f78A-4lisA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1004_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4lis UDP-GLUCOSE
4-EPIMERASE
(Aspergillus
nidulans) 		4 / 7 VAL A 170
PHE A 125
HIS A  83
THR A 108
 IOD  A 406 ( 4.9A)
None
None
None
 1.12A 2f78B-4lisA:
undetectable		 2f78B-4lisA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G78_A_REAA200_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 4lis UDP-GLUCOSE
4-EPIMERASE
(Aspergillus
nidulans) 		5 / 12 ALA A  33
VAL A  71
VAL A  30
ARG A 271
LEU A 267
 None
 1.16A 2g78A-4lisA:
undetectable		 2g78A-4lisA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_A_ANWA99_0
(PROTEIN S100-A13)		 4lis UDP-GLUCOSE
4-EPIMERASE
(Aspergillus
nidulans) 		4 / 7 VAL A  62
THR A  63
PHE A  68
ARG A 113
 NAD  A 402 (-3.8A)
NAD  A 402 ( 4.7A)
None
None
 1.26A 2kotA-4lisA:
undetectable		 2kotA-4lisA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_D_BEZD1221_0
(PEROXIREDOXIN 6)		 4lis UDP-GLUCOSE
4-EPIMERASE
(Aspergillus
nidulans) 		4 / 8 VAL A 216
PRO A 217
PRO A 213
ARG A 358
 None
 0.94A 2v32C-4lisA:
undetectable
2v32D-4lisA:
undetectable		 2v32C-4lisA:
19.79
2v32D-4lisA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		 4lis UDP-GLUCOSE
4-EPIMERASE
(Aspergillus
nidulans) 		3 / 3 GLU A 292
HIS A 245
THR A 289
 None
 0.89A 3hkuA-4lisA:
undetectable		 3hkuA-4lisA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		 4lis UDP-GLUCOSE
4-EPIMERASE
(Aspergillus
nidulans) 		4 / 7 TYR A 357
PRO A 361
GLN A 360
GLU A 364
 None
 1.27A 3l2vA-4lisA:
undetectable		 3l2vA-4lisA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_C_ACTC4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 4lis UDP-GLUCOSE
4-EPIMERASE
(Aspergillus
nidulans) 		4 / 4 GLY A  10
GLY A  16
THR A  20
LEU A  44
 NAD  A 402 ( 3.8A)
None
None
None
 0.92A 3si7C-4lisA:
undetectable
3si7D-4lisA:
undetectable		 3si7C-4lisA:
20.62
3si7D-4lisA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOA_A_ACRA1587_2
(TREHALOSE
SYNTHASE/AMYLASE
TRES)		 4lis UDP-GLUCOSE
4-EPIMERASE
(Aspergillus
nidulans) 		3 / 3 ARG A 137
PHE A 138
PRO A 139
 None
 0.39A 3zoaB-4lisA:
2.6		 3zoaB-4lisA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1004_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4lis UDP-GLUCOSE
4-EPIMERASE
(Aspergillus
nidulans) 		5 / 11 VAL A  30
ALA A  55
GLY A  16
PHE A 125
LEU A  44
 None
 1.00A 3zosA-4lisA:
undetectable
3zosB-4lisA:
undetectable		 3zosA-4lisA:
23.02
3zosB-4lisA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4lis UDP-GLUCOSE
4-EPIMERASE
(Aspergillus
nidulans) 		5 / 12 VAL A   8
ALA A  85
SER A  17
LEU A  44
VAL A  32
 None
NAD  A 402 (-3.9A)
None
None
None
 1.27A 4kyaF-4lisA:
undetectable		 4kyaF-4lisA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKN_B_KANB403_1
(L-LACTATE
DEHYDROGENASE A
CHAIN)		 4lis UDP-GLUCOSE
4-EPIMERASE
(Aspergillus
nidulans) 		5 / 9 VAL A 317
ALA A 135
ARG A 196
ILE A 144
ILE A 142
 None
None
GOL  A 403 ( 3.9A)
None
None
 1.37A 4oknB-4lisA:
7.3		 4oknB-4lisA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_2
(ANDROGEN RECEPTOR)		 4lis UDP-GLUCOSE
4-EPIMERASE
(Aspergillus
nidulans) 		4 / 6 ASN A 122
ILE A 167
ILE A 171
VAL A 170
 None
None
None
IOD  A 406 ( 4.9A)
 0.95A 4olmA-4lisA:
undetectable		 4olmA-4lisA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_I_IPHI101_0
(INSULIN)		 4lis UDP-GLUCOSE
4-EPIMERASE
(Aspergillus
nidulans) 		5 / 12 ILE A 123
LEU A 270
HIS A 263
LEU A 267
ALA A 266
 None
 0.93A 4p65B-4lisA:
undetectable
4p65D-4lisA:
undetectable
4p65I-4lisA:
undetectable
4p65J-4lisA:
undetectable		 4p65B-4lisA:
5.43
4p65D-4lisA:
5.43
4p65I-4lisA:
3.26
4p65J-4lisA:
5.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_K_IPHK101_0
(INSULIN)		 4lis UDP-GLUCOSE
4-EPIMERASE
(Aspergillus
nidulans) 		5 / 12 ILE A 123
LEU A 270
HIS A 263
LEU A 267
ALA A 266
 None
 1.01A 4p65F-4lisA:
undetectable
4p65H-4lisA:
undetectable
4p65K-4lisA:
undetectable
4p65L-4lisA:
undetectable		 4p65F-4lisA:
5.43
4p65H-4lisA:
5.43
4p65K-4lisA:
3.26
4p65L-4lisA:
5.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_A_SAMA401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 4lis UDP-GLUCOSE
4-EPIMERASE
(Aspergillus
nidulans) 		5 / 11 GLY A  10
GLY A  11
THR A  19
ASP A  34
ASP A  61
 NAD  A 402 ( 3.8A)
None
None
NAD  A 402 (-2.5A)
NAD  A 402 (-3.1A)
 0.88A 4pghA-4lisA:
5.5		 4pghA-4lisA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4lis UDP-GLUCOSE
4-EPIMERASE
(Aspergillus
nidulans) 		5 / 12 GLY A  11
GLY A  10
THR A   9
ILE A  82
ILE A  15
 None
NAD  A 402 ( 3.8A)
None
None
NAD  A 402 (-3.9A)
 1.26A 4zvmA-4lisA:
5.7
4zvmB-4lisA:
3.9		 4zvmA-4lisA:
21.13
4zvmB-4lisA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4lis UDP-GLUCOSE
4-EPIMERASE
(Aspergillus
nidulans) 		3 / 3 ASP A 246
LEU A 339
ARG A 286
 None
 0.63A 5e8qA-4lisA:
undetectable		 5e8qA-4lisA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_E_IPHE101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 4lis UDP-GLUCOSE
4-EPIMERASE
(Aspergillus
nidulans) 		4 / 7 ILE A 123
HIS A 263
LEU A 267
ALA A 266
 None
 0.93A 5hrqE-4lisA:
undetectable
5hrqF-4lisA:
undetectable
5hrqJ-4lisA:
undetectable		 5hrqE-4lisA:
3.26
5hrqF-4lisA:
5.07
5hrqJ-4lisA:
5.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 4lis UDP-GLUCOSE
4-EPIMERASE
(Aspergillus
nidulans) 		5 / 12 GLY A  11
ASN A  35
ASP A  61
VAL A  62
THR A  63
 None
NAD  A 402 (-3.2A)
NAD  A 402 (-3.1A)
NAD  A 402 (-3.8A)
NAD  A 402 ( 4.7A)
 1.05A 5kpcB-4lisA:
5.2		 5kpcB-4lisA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB308_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4lis UDP-GLUCOSE
4-EPIMERASE
(Aspergillus
nidulans) 		3 / 3 LEU A  21
ILE A  47
TYR A 357
 None
 0.69A 5uunB-4lisA:
undetectable		 5uunB-4lisA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_A_ECLA1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 4lis UDP-GLUCOSE
4-EPIMERASE
(Aspergillus
nidulans) 		4 / 7 ILE A  82
PHE A  68
ILE A  47
ALA A  58
 None
 0.86A 6b5vA-4lisA:
undetectable
6b5vC-4lisA:
undetectable		 6b5vA-4lisA:
13.92
6b5vC-4lisA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_C_ECLC1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 4lis UDP-GLUCOSE
4-EPIMERASE
(Aspergillus
nidulans) 		4 / 7 ILE A  82
PHE A  68
ILE A  47
ALA A  58
 None
 0.87A 6b5vC-4lisA:
undetectable
6b5vD-4lisA:
undetectable		 6b5vC-4lisA:
13.92
6b5vD-4lisA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_D_ECLD1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 4lis UDP-GLUCOSE
4-EPIMERASE
(Aspergillus
nidulans) 		4 / 7 ALA A  58
ILE A  82
PHE A  68
ILE A  47
 None
 0.85A 6b5vB-4lisA:
undetectable
6b5vD-4lisA:
undetectable		 6b5vB-4lisA:
13.92
6b5vD-4lisA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CK2_C_IPHC101_0
(INSULIN A CHAIN
INSULIN B CHAIN)		 4lis UDP-GLUCOSE
4-EPIMERASE
(Aspergillus
nidulans) 		4 / 4 ILE A 123
LEU A 270
HIS A 263
ALA A 266
 None
 1.05A 6ck2C-4lisA:
undetectable
6ck2D-4lisA:
undetectable		 6ck2C-4lisA:
3.26
6ck2D-4lisA:
5.16