SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lj0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_A_CUA1599_0
(NITROUS OXIDE
REDUCTASE)		 4lj0 NAB2
(Chaetomium
thermophilum) 		3 / 3 CYH A 437
CYH A 426
HIS A 441
 ZN  A 502 (-2.2A)
A  E   2 (-2.1A)
ZN  A 502 (-3.2A)
 0.78A 2iwkA-4lj0A:
undetectable		 2iwkA-4lj0A:
6.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_A_CUA1599_0
(NITROUS OXIDE
REDUCTASE)		 4lj0 NAB2
(Chaetomium
thermophilum) 		3 / 3 CYH A 456
CYH A 446
HIS A 460
 ZN  A 503 (-2.2A)
ZN  A 503 (-2.3A)
ZN  A 503 (-3.1A)
 0.79A 2iwkA-4lj0A:
undetectable		 2iwkA-4lj0A:
6.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_B_CUB1599_0
(NITROUS OXIDE
REDUCTASE)		 4lj0 NAB2
(Chaetomium
thermophilum) 		3 / 3 CYH A 437
CYH A 426
HIS A 441
 ZN  A 502 (-2.2A)
A  E   2 (-2.1A)
ZN  A 502 (-3.2A)
 0.77A 2iwkB-4lj0A:
undetectable		 2iwkB-4lj0A:
6.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_B_CUB1599_0
(NITROUS OXIDE
REDUCTASE)		 4lj0 NAB2
(Chaetomium
thermophilum) 		3 / 3 CYH A 456
CYH A 446
HIS A 460
 ZN  A 503 (-2.2A)
ZN  A 503 (-2.3A)
ZN  A 503 (-3.1A)
 0.79A 2iwkB-4lj0A:
undetectable		 2iwkB-4lj0A:
6.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_B_CUB1022_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 4lj0 NAB2
(Chaetomium
thermophilum) 		3 / 3 CYH A 437
CYH A 426
HIS A 441
 ZN  A 502 (-2.2A)
A  E   2 (-2.1A)
ZN  A 502 (-3.2A)
 0.87A 3dtuB-4lj0A:
undetectable		 3dtuB-4lj0A:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_D_CUD3_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 4lj0 NAB2
(Chaetomium
thermophilum) 		3 / 3 CYH A 437
CYH A 426
HIS A 441
 ZN  A 502 (-2.2A)
A  E   2 (-2.1A)
ZN  A 502 (-3.2A)
 0.85A 3dtuD-4lj0A:
undetectable		 3dtuD-4lj0A:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SU9_A_ACTA426_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4lj0 NAB2
(Chaetomium
thermophilum) 		3 / 3 GLN A 403
GLU A 402
LYS A 402
 None
 0.78A 3su9A-4lj0A:
undetectable		 3su9A-4lj0A:
9.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LJ0_A_ACTA505_0
(NAB2)		 4lj0 NAB2
(Chaetomium
thermophilum) 		3 / 3 LEU A 442
LYS A 443
THR A 444
 ACT  A 505 (-3.6A)
ACT  A 505 (-4.7A)
ACT  A 505 (-3.9A)
 0.02A 4lj0A-4lj0A:
14.5		 4lj0A-4lj0A:
100.00