SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lj2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_2
(TRANSTHYRETIN)		 4lj2 CHORISMATE SYNTHASE
(Acinetobacter
baumannii) 		4 / 7 ALA A  25
LEU A  23
THR A  14
VAL A  12
 None
 0.76A 1dvxB-4lj2A:
undetectable		 1dvxB-4lj2A:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q8H_A_TF4A438_1
([PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1)		 4lj2 CHORISMATE SYNTHASE
(Acinetobacter
baumannii) 		4 / 6 LEU A 336
ILE A 286
ARG A 154
ILE A 153
 None
 0.95A 2q8hA-4lj2A:
undetectable		 2q8hA-4lj2A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4lj2 CHORISMATE SYNTHASE
(Acinetobacter
baumannii) 		4 / 7 ILE A 140
PHE A  10
ARG A 134
THR A  14
 None
 1.03A 3ag2N-4lj2A:
undetectable
3ag2W-4lj2A:
undetectable		 3ag2N-4lj2A:
21.71
3ag2W-4lj2A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4lj2 CHORISMATE SYNTHASE
(Acinetobacter
baumannii) 		4 / 7 ILE A 140
PHE A  10
ARG A 134
THR A  14
 None
 1.06A 3ag4N-4lj2A:
undetectable
3ag4W-4lj2A:
undetectable		 3ag4N-4lj2A:
21.71
3ag4W-4lj2A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXT_A_SAMA397_0
(PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1)		 4lj2 CHORISMATE SYNTHASE
(Acinetobacter
baumannii) 		5 / 12 ALA A 211
ARG A 154
ILE A 245
GLU A 244
ALA A 289
 None
 1.22A 3axtA-4lj2A:
undetectable		 3axtA-4lj2A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_B_1FLB500_1
(TRANSTHYRETIN)		 4lj2 CHORISMATE SYNTHASE
(Acinetobacter
baumannii) 		4 / 6 ALA A  25
LEU A  23
THR A  14
VAL A  12
 None
 0.69A 3d2tB-4lj2A:
undetectable		 3d2tB-4lj2A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCM_X_SAMX5452_0
(UNCHARACTERIZED
PROTEIN TM_1570)		 4lj2 CHORISMATE SYNTHASE
(Acinetobacter
baumannii) 		6 / 11 ALA A 239
GLY A 204
ILE A 237
ASN A 238
VAL A 326
ALA A 328
 None
 0.95A 3dcmX-4lj2A:
undetectable		 3dcmX-4lj2A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4lj2 CHORISMATE SYNTHASE
(Acinetobacter
baumannii) 		4 / 5 PRO A 363
THR A  76
GLY A  33
LYS A  75
 None
 1.13A 3elzA-4lj2A:
undetectable		 3elzA-4lj2A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_1
(CYTOCHROME P450 3A4)		 4lj2 CHORISMATE SYNTHASE
(Acinetobacter
baumannii) 		5 / 12 LEU A 340
ILE A 230
ALA A 233
ILE A 331
ALA A 328
 None
 1.16A 3nxuB-4lj2A:
undetectable		 3nxuB-4lj2A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_B_T44B128_1
(TRANSTHYRETIN)		 4lj2 CHORISMATE SYNTHASE
(Acinetobacter
baumannii) 		4 / 7 ALA A  25
LEU A  23
THR A  14
VAL A  12
 None
 0.59A 3ozkB-4lj2A:
undetectable		 3ozkB-4lj2A:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1001_1
(HEMOLYTIC LECTIN
CEL-III)		 4lj2 CHORISMATE SYNTHASE
(Acinetobacter
baumannii) 		4 / 5 ASP A  89
VAL A  21
GLY A  22
ASP A  63
 None
 1.14A 3w9tA-4lj2A:
undetectable		 3w9tA-4lj2A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB503_1
(HEMOLYTIC LECTIN
CEL-III)		 4lj2 CHORISMATE SYNTHASE
(Acinetobacter
baumannii) 		4 / 5 ASP A  89
VAL A  21
GLY A  22
ASP A  63
 None
 1.14A 3w9tB-4lj2A:
undetectable		 3w9tB-4lj2A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1001_1
(HEMOLYTIC LECTIN
CEL-III)		 4lj2 CHORISMATE SYNTHASE
(Acinetobacter
baumannii) 		4 / 5 ASP A  89
VAL A  21
GLY A  22
ASP A  63
 None
 1.13A 3w9tC-4lj2A:
undetectable		 3w9tC-4lj2A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD502_1
(HEMOLYTIC LECTIN
CEL-III)		 4lj2 CHORISMATE SYNTHASE
(Acinetobacter
baumannii) 		4 / 5 ASP A  89
VAL A  21
GLY A  22
ASP A  63
 None
 1.14A 3w9tD-4lj2A:
undetectable		 3w9tD-4lj2A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE504_1
(HEMOLYTIC LECTIN
CEL-III)		 4lj2 CHORISMATE SYNTHASE
(Acinetobacter
baumannii) 		4 / 5 ASP A  89
VAL A  21
GLY A  22
ASP A  63
 None
 1.14A 3w9tE-4lj2A:
undetectable		 3w9tE-4lj2A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF504_1
(HEMOLYTIC LECTIN
CEL-III)		 4lj2 CHORISMATE SYNTHASE
(Acinetobacter
baumannii) 		4 / 5 ASP A  89
VAL A  21
GLY A  22
ASP A  63
 None
 1.14A 3w9tF-4lj2A:
undetectable		 3w9tF-4lj2A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG504_1
(HEMOLYTIC LECTIN
CEL-III)		 4lj2 CHORISMATE SYNTHASE
(Acinetobacter
baumannii) 		4 / 5 ASP A  89
VAL A  21
GLY A  22
ASP A  63
 None
 1.14A 3w9tG-4lj2A:
undetectable		 3w9tG-4lj2A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_1
(METHYLTRANSFERASE
NSUN4)		 4lj2 CHORISMATE SYNTHASE
(Acinetobacter
baumannii) 		3 / 3 ASP A 342
ARG A 346
ASP A  28
 None
 0.82A 4fp9A-4lj2A:
undetectable		 4fp9A-4lj2A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_B_IMNB201_1
(TRANSTHYRETIN)		 4lj2 CHORISMATE SYNTHASE
(Acinetobacter
baumannii) 		4 / 8 ALA A  25
LEU A  23
THR A  14
VAL A  12
 None
 0.63A 4ik7B-4lj2A:
undetectable		 4ik7B-4lj2A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_B_MXMB606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4lj2 CHORISMATE SYNTHASE
(Acinetobacter
baumannii) 		5 / 12 VAL A 240
ILE A 209
VAL A 288
ALA A 231
LEU A 336
 None
 1.04A 4m11B-4lj2A:
undetectable		 4m11B-4lj2A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_D_MXMD606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4lj2 CHORISMATE SYNTHASE
(Acinetobacter
baumannii) 		5 / 12 VAL A 339
ILE A 276
LEU A 226
VAL A 151
ALA A 211
 None
 1.20A 4m11D-4lj2A:
undetectable		 4m11D-4lj2A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4lj2 CHORISMATE SYNTHASE
(Acinetobacter
baumannii) 		4 / 6 ILE A 140
PHE A  10
ARG A 134
THR A  14
 None
 1.02A 5b1aN-4lj2A:
undetectable
5b1aW-4lj2A:
undetectable		 5b1aN-4lj2A:
21.71
5b1aW-4lj2A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4lj2 CHORISMATE SYNTHASE
(Acinetobacter
baumannii) 		4 / 5 ILE A 140
PHE A  10
ARG A 134
THR A  14
 None
 1.12A 5z84N-4lj2A:
undetectable
5z84W-4lj2A:
undetectable		 5z84N-4lj2A:
21.71
5z84W-4lj2A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA812_0
(GEPHYRIN)		 4lj2 CHORISMATE SYNTHASE
(Acinetobacter
baumannii) 		4 / 6 GLU A 333
ARG A  47
VAL A 173
PRO A 174
 None
 1.38A 6fgdA-4lj2A:
undetectable		 6fgdA-4lj2A:
22.94