SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ljp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QCA_A_FUAA221_1
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4ljp E3 UBIQUITIN-PROTEIN
LIGASE RNF31
(Homo
sapiens) 		4 / 7 CYH A 898
SER A 899
PHE A 932
PHE A 905
 ZN  A1102 (-2.4A)
None
None
None
 1.04A 1qcaA-4ljpA:
undetectable		 1qcaA-4ljpA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4ljp E3 UBIQUITIN-PROTEIN
LIGASE RNF31
(Homo
sapiens) 		4 / 5 LEU A1057
GLY A1064
PRO A1017
ALA A1018
 None
 0.80A 2aohA-4ljpA:
undetectable		 2aohA-4ljpA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLJ_A_SPMA1303_1
(POTASSIUM CHANNEL)		 4ljp E3 UBIQUITIN-PROTEIN
LIGASE RNF31
(Homo
sapiens) 		3 / 3 ARG A 928
ARG A1032
PRO A 927
 None
 1.03A 2wljA-4ljpA:
undetectable		 2wljA-4ljpA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAT_A_CLMA301_0
(XENOBIOTIC
ACETYLTRANSFERASE)		 4ljp E3 UBIQUITIN-PROTEIN
LIGASE RNF31
(Homo
sapiens) 		3 / 3 GLY A 900
TYR A 902
SER A 899
 ZN  A1102 ( 4.3A)
None
None
 0.78A 2xatA-4ljpA:
undetectable		 2xatA-4ljpA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O01_B_DXCB1_0
(CELL INVASION
PROTEIN SIPD)		 4ljp E3 UBIQUITIN-PROTEIN
LIGASE RNF31
(Homo
sapiens) 		5 / 9 ARG A1069
ILE A1010
ALA A1012
LEU A 946
ASN A 949
 None
 1.46A 3o01A-4ljpA:
undetectable
3o01B-4ljpA:
undetectable		 3o01A-4ljpA:
19.75
3o01B-4ljpA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_B_SVRB516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 4ljp E3 UBIQUITIN-PROTEIN
LIGASE RNF31
(Homo
sapiens) 		4 / 7 PRO A 958
GLY A 960
ALA A 961
ARG A 962
 None
 0.65A 3ur0B-4ljpA:
undetectable		 3ur0B-4ljpA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA809_1
(CATALASE-PEROXIDASE)		 4ljp E3 UBIQUITIN-PROTEIN
LIGASE RNF31
(Homo
sapiens) 		4 / 8 GLU A 956
GLY A 996
LEU A 997
THR A 990
 None
 1.10A 5syjA-4ljpA:
undetectable		 5syjA-4ljpA:
16.72