SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ljs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C8L_A_CFFA940_1
(PROTEIN (GLYCOGEN
PHOSPHORYLASE))		 4ljs PERIPLASMIC BINDING
PROTEIN
(Veillonella
parvula) 		4 / 6 ASN A  69
ALA A 155
GLY A 129
TYR A 153
 None
 1.12A 1c8lA-4ljsA:
undetectable		 1c8lA-4ljsA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RV7_B_AB1B1001_1
(PROTEASE)		 4ljs PERIPLASMIC BINDING
PROTEIN
(Veillonella
parvula) 		5 / 11 ILE A 244
VAL A 308
PRO A 261
ALA A 294
VAL A 300
 None
 1.19A 1rv7A-4ljsA:
undetectable
1rv7B-4ljsA:
undetectable		 1rv7A-4ljsA:
14.51
1rv7B-4ljsA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_B_RBFB596_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 4ljs PERIPLASMIC BINDING
PROTEIN
(Veillonella
parvula) 		5 / 11 VAL A  63
VAL A 128
TYR A 153
GLU A  61
ILE A 180
 None
 0.94A 1t6zB-4ljsA:
2.5		 1t6zB-4ljsA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		 4ljs PERIPLASMIC BINDING
PROTEIN
(Veillonella
parvula) 		4 / 4 LEU A  77
PRO A 311
ILE A 191
LEU A 190
 None
 1.17A 1ya4C-4ljsA:
undetectable		 1ya4C-4ljsA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2002_1
(SERUM ALBUMIN)		 4ljs PERIPLASMIC BINDING
PROTEIN
(Veillonella
parvula) 		4 / 8 ARG A  62
ALA A  85
GLU A  25
LEU A 120
 None
 0.80A 2bxgA-4ljsA:
undetectable		 2bxgA-4ljsA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_C_DVAC8_0
(GRAMICIDIN A)		 4ljs PERIPLASMIC BINDING
PROTEIN
(Veillonella
parvula) 		3 / 3 VAL A 128
TRP A  67
TRP A 130
 None
None
GOL  A 401 (-4.9A)
 1.21A 2xdcC-4ljsA:
undetectable
2xdcD-4ljsA:
undetectable		 2xdcC-4ljsA:
3.45
2xdcD-4ljsA:
3.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJ8_C_SPMC500_1
(DIAMINE
ACETYLTRANSFERASE 1)		 4ljs PERIPLASMIC BINDING
PROTEIN
(Veillonella
parvula) 		4 / 6 ASP A 262
LEU A 214
ASP A 242
HIS A 228
 None
 1.27A 3bj8C-4ljsA:
undetectable
3bj8D-4ljsA:
undetectable		 3bj8C-4ljsA:
17.85
3bj8D-4ljsA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A2000_1
(P38A)		 4ljs PERIPLASMIC BINDING
PROTEIN
(Veillonella
parvula) 		5 / 12 ASP A  81
ILE A 106
ILE A 174
ILE A  71
ALA A 102
 None
 1.23A 3ohtA-4ljsA:
undetectable
3ohtB-4ljsA:
undetectable		 3ohtA-4ljsA:
22.64
3ohtB-4ljsA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A2000_1
(P38A)		 4ljs PERIPLASMIC BINDING
PROTEIN
(Veillonella
parvula) 		5 / 12 ILE A 106
ILE A 174
ILE A  71
ALA A 102
TYR A 103
 None
 1.08A 3ohtA-4ljsA:
undetectable
3ohtB-4ljsA:
undetectable		 3ohtA-4ljsA:
22.64
3ohtB-4ljsA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		 4ljs PERIPLASMIC BINDING
PROTEIN
(Veillonella
parvula) 		3 / 3 LEU A 266
MET A 280
ASP A 255
 None
 0.70A 4j7xB-4ljsA:
2.8		 4j7xB-4ljsA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4C_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 4ljs PERIPLASMIC BINDING
PROTEIN
(Veillonella
parvula) 		4 / 8 LEU A 295
VAL A 300
VAL A 218
ILE A 216
 None
 0.89A 4l4cB-4ljsA:
undetectable		 4l4cB-4ljsA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_V_BEZV801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 4ljs PERIPLASMIC BINDING
PROTEIN
(Veillonella
parvula) 		4 / 4 ILE A 174
ILE A 191
ARG A 175
LEU A 315
 None
 1.18A 5dzkh-4ljsA:
undetectable
5dzkn-4ljsA:
undetectable
5dzkv-4ljsA:
undetectable		 5dzkh-4ljsA:
20.67
5dzkn-4ljsA:
20.67
5dzkv-4ljsA:
1.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 4ljs PERIPLASMIC BINDING
PROTEIN
(Veillonella
parvula) 		3 / 3 ARG A 299
PRO A 328
ASN A 329
 None
 1.04A 5jwaA-4ljsA:
3.7
5jwaH-4ljsA:
3.1		 5jwaA-4ljsA:
20.95
5jwaH-4ljsA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMD_C_6UBC1304_1
(ION TRANSPORT
PROTEIN)		 4ljs PERIPLASMIC BINDING
PROTEIN
(Veillonella
parvula) 		4 / 5 ILE A  34
LEU A 177
GLY A 178
PHE A 181
 None
 0.94A 5kmdC-4ljsA:
undetectable
5kmdD-4ljsA:
undetectable		 5kmdC-4ljsA:
21.61
5kmdD-4ljsA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_J_Z80J401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4ljs PERIPLASMIC BINDING
PROTEIN
(Veillonella
parvula) 		5 / 12 ILE A 251
PHE A 215
ASN A 293
ASP A 262
ILE A 264
 None
 1.17A 5lg3J-4ljsA:
undetectable		 5lg3J-4ljsA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZ0_A_ZLDA301_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR)		 4ljs PERIPLASMIC BINDING
PROTEIN
(Veillonella
parvula) 		5 / 12 GLY A 236
ILE A 235
THR A 201
VAL A 202
LEU A 303
 None
 1.10A 5nz0A-4ljsA:
undetectable		 5nz0A-4ljsA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4ljs PERIPLASMIC BINDING
PROTEIN
(Veillonella
parvula) 		3 / 3 TYR A  99
ARG A 314
THR A  73
 None
 0.68A 5z84J-4ljsA:
undetectable		 5z84J-4ljsA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4ljs PERIPLASMIC BINDING
PROTEIN
(Veillonella
parvula) 		4 / 5 TYR A  99
ARG A 314
THR A  73
LEU A  77
 None
 1.33A 5z86J-4ljsA:
undetectable		 5z86J-4ljsA:
11.07