SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lk2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 4lk2 PRE-MRNA-PROCESSING
ATP-DEPENDENT RNA
HELICASE PRP5
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 393
LEU A 404
ILE A 409
LEU A 334
ILE A 432
 None
 1.28A 1re7B-4lk2A:
undetectable		 1re7B-4lk2A:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_2
(PHOSPHOLIPASE A2)		 4lk2 PRE-MRNA-PROCESSING
ATP-DEPENDENT RNA
HELICASE PRP5
(Saccharomyces
cerevisiae) 		4 / 5 VAL A 386
VAL A 385
PHE A 353
ARG A 380
 None
 1.20A 3bjwB-4lk2A:
undetectable		 3bjwB-4lk2A:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA2_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 4lk2 PRE-MRNA-PROCESSING
ATP-DEPENDENT RNA
HELICASE PRP5
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 440
LYS A 434
VAL A 436
 None
 1.01A 3brfA-4lk2A:
undetectable		 3brfA-4lk2A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_4
(HIV-1 PROTEASE)		 4lk2 PRE-MRNA-PROCESSING
ATP-DEPENDENT RNA
HELICASE PRP5
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 503
VAL A 479
THR A 616
 None
 0.79A 3k4vD-4lk2A:
undetectable		 3k4vD-4lk2A:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_A_CAMA423_0
(CYTOCHROME P450)		 4lk2 PRE-MRNA-PROCESSING
ATP-DEPENDENT RNA
HELICASE PRP5
(Saccharomyces
cerevisiae) 		5 / 10 THR A 329
THR A 435
LEU A 404
LEU A 396
VAL A 436
 None
 1.28A 3lxiA-4lk2A:
undetectable		 3lxiA-4lk2A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFE_C_TMGC1_1
(SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL)		 4lk2 PRE-MRNA-PROCESSING
ATP-DEPENDENT RNA
HELICASE PRP5
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 282
TRP A 257
SER A 309
ILE A 308
 None
 0.97A 3sfeB-4lk2A:
undetectable
3sfeC-4lk2A:
undetectable		 3sfeB-4lk2A:
17.68
3sfeC-4lk2A:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_0
(PUTATIVE REGULATORY
PROTEIN)		 4lk2 PRE-MRNA-PROCESSING
ATP-DEPENDENT RNA
HELICASE PRP5
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 311
ILE A 290
ILE A 346
ALA A 337
PHE A 445
 None
 1.22A 3vw1D-4lk2A:
undetectable		 3vw1D-4lk2A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_A_CAMA423_0
(CYTOCHROME P450)		 4lk2 PRE-MRNA-PROCESSING
ATP-DEPENDENT RNA
HELICASE PRP5
(Saccharomyces
cerevisiae) 		5 / 9 THR A 329
THR A 435
LEU A 404
LEU A 396
VAL A 436
 None
 1.23A 4c9pA-4lk2A:
undetectable		 4c9pA-4lk2A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_B_CAMB423_0
(CYTOCHROME P450)		 4lk2 PRE-MRNA-PROCESSING
ATP-DEPENDENT RNA
HELICASE PRP5
(Saccharomyces
cerevisiae) 		5 / 10 THR A 329
THR A 435
LEU A 404
LEU A 396
VAL A 436
 None
 1.25A 4c9pB-4lk2A:
undetectable		 4c9pB-4lk2A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4lk2 PRE-MRNA-PROCESSING
ATP-DEPENDENT RNA
HELICASE PRP5
(Saccharomyces
cerevisiae) 		4 / 8 SER A 622
GLN A 481
ILE A 599
VAL A 603
 None
 0.93A 4dx7B-4lk2A:
undetectable		 4dx7B-4lk2A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QN9_B_DXCB610_0
(N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D)		 4lk2 PRE-MRNA-PROCESSING
ATP-DEPENDENT RNA
HELICASE PRP5
(Saccharomyces
cerevisiae) 		3 / 3 GLY A 390
PRO A 389
ALA A 337
 None
 0.52A 4qn9B-4lk2A:
1.5		 4qn9B-4lk2A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2O_B_CLQB1079_0
(SAPOSIN-B)		 4lk2 PRE-MRNA-PROCESSING
ATP-DEPENDENT RNA
HELICASE PRP5
(Saccharomyces
cerevisiae) 		3 / 3 MET A 228
GLU A 232
LEU A 236
 None
 0.67A 4v2oB-4lk2A:
undetectable		 4v2oB-4lk2A:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4lk2 PRE-MRNA-PROCESSING
ATP-DEPENDENT RNA
HELICASE PRP5
(Saccharomyces
cerevisiae) 		4 / 7 GLN A 317
VAL A 318
ILE A 384
THR A 382
 None
 0.89A 6cduF-4lk2A:
undetectable
6cduG-4lk2A:
undetectable		 6cduF-4lk2A:
21.88
6cduG-4lk2A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IE8_A_CHDA201_0
(REGULATORY PROTEIN)		 4lk2 PRE-MRNA-PROCESSING
ATP-DEPENDENT RNA
HELICASE PRP5
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 596
THR A 552
ILE A 578
LEU A 545
LEU A 628
 None
 1.13A 6ie8A-4lk2A:
undetectable		 6ie8A-4lk2A:
16.99