SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lk3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		 4lk3 UDP-GLUCURONIC ACID
DECARBOXYLASE 1
(Homo
sapiens) 		4 / 5 LEU A 176
SER A 201
LEU A 199
GLY A 234
 None
 1.05A 1a4lB-4lk3A:
undetectable		 1a4lB-4lk3A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAY_A_ADNA1001_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 4lk3 UDP-GLUCURONIC ACID
DECARBOXYLASE 1
(Homo
sapiens) 		6 / 11 GLY A  95
ALA A  97
ASP A 119
ASP A 144
VAL A 145
ALA A 160
 NAD  A 501 (-3.3A)
NAD  A 501 (-4.7A)
NAD  A 501 (-3.1A)
NAD  A 501 (-3.1A)
NAD  A 501 (-3.6A)
NAD  A 501 (-3.9A)
 0.37A 1uayA-4lk3A:
15.3		 1uayA-4lk3A:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAY_B_ADNB1002_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 4lk3 UDP-GLUCURONIC ACID
DECARBOXYLASE 1
(Homo
sapiens) 		6 / 10 GLY A  95
ALA A  97
ASP A 119
ASP A 144
VAL A 145
ALA A 160
 NAD  A 501 (-3.3A)
NAD  A 501 (-4.7A)
NAD  A 501 (-3.1A)
NAD  A 501 (-3.1A)
NAD  A 501 (-3.6A)
NAD  A 501 (-3.9A)
 0.37A 1uayB-4lk3A:
15.5		 1uayB-4lk3A:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_B_SAMB4001_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 4lk3 UDP-GLUCURONIC ACID
DECARBOXYLASE 1
(Homo
sapiens) 		5 / 12 GLY A  95
GLY A  98
ASP A 144
VAL A 145
PRO A 162
 NAD  A 501 (-3.3A)
NAD  A 501 (-3.1A)
NAD  A 501 (-3.1A)
NAD  A 501 (-3.6A)
NAD  A 501 ( 4.0A)
 0.92A 1zq9B-4lk3A:
5.5		 1zq9B-4lk3A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 4lk3 UDP-GLUCURONIC ACID
DECARBOXYLASE 1
(Homo
sapiens) 		5 / 11 LEU A 312
ILE A 365
PRO A 326
ASN A 325
GLN A 300
 None
 1.19A 2ft9A-4lk3A:
undetectable		 2ft9A-4lk3A:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_2
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 4lk3 UDP-GLUCURONIC ACID
DECARBOXYLASE 1
(Homo
sapiens) 		4 / 6 PHE A  99
ARG A 125
ASN A 269
ASN A 171
 None
SO4  A 504 ( 4.4A)
SO4  A 504 (-3.8A)
None
 1.27A 2nyrA-4lk3A:
4.6		 2nyrA-4lk3A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VL2_B_BEZB1162_0
(PEROXIREDOXIN-5)		 4lk3 UDP-GLUCURONIC ACID
DECARBOXYLASE 1
(Homo
sapiens) 		4 / 7 THR A 105
GLY A 101
LEU A 140
PHE A 138
 None
 1.02A 2vl2B-4lk3A:
undetectable		 2vl2B-4lk3A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)		 4lk3 UDP-GLUCURONIC ACID
DECARBOXYLASE 1
(Homo
sapiens) 		4 / 6 GLU A 204
LYS A 361
PHE A 259
ILE A 258
 None
None
None
NAD  A 501 (-3.9A)
 1.03A 2w98B-4lk3A:
5.7		 2w98B-4lk3A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_A_ECNA403_1
(FLAVOHEMOGLOBIN)		 4lk3 UDP-GLUCURONIC ACID
DECARBOXYLASE 1
(Homo
sapiens) 		5 / 12 LEU A 305
VAL A 310
LEU A 309
TYR A 157
ILE A  93
 None
 1.07A 4g1bA-4lk3A:
2.4		 4g1bA-4lk3A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4lk3 UDP-GLUCURONIC ACID
DECARBOXYLASE 1
(Homo
sapiens) 		4 / 7 ILE A  93
LEU A 159
GLY A  98
GLY A 101
 None
NAD  A 501 (-4.4A)
NAD  A 501 (-3.1A)
None
 0.86A 5a06B-4lk3A:
5.2		 5a06B-4lk3A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND3_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 4lk3 UDP-GLUCURONIC ACID
DECARBOXYLASE 1
(Homo
sapiens) 		5 / 12 VAL A 145
HIS A 158
LEU A 159
ALA A 160
THR A 202
 NAD  A 501 (-3.6A)
None
NAD  A 501 (-4.4A)
NAD  A 501 (-3.9A)
NAD  A 501 (-4.0A)
 1.13A 5nd3B-4lk3A:
undetectable		 5nd3B-4lk3A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_1
(WTFP-TAG,GP41)		 4lk3 UDP-GLUCURONIC ACID
DECARBOXYLASE 1
(Homo
sapiens) 		5 / 12 ALA A  97
GLY A  96
ASN A 137
GLU A 114
LEU A 108
 NAD  A 501 (-4.7A)
None
None
None
None
 1.24A 5nwuA-4lk3A:
undetectable		 5nwuA-4lk3A:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_A_ECLA1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 4lk3 UDP-GLUCURONIC ACID
DECARBOXYLASE 1
(Homo
sapiens) 		4 / 7 ILE A 258
LEU A 323
ILE A  93
ALA A 311
 NAD  A 501 (-3.9A)
None
None
None
 0.80A 6b5vA-4lk3A:
undetectable
6b5vC-4lk3A:
undetectable		 6b5vA-4lk3A:
15.97
6b5vC-4lk3A:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_C_ECLC1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 4lk3 UDP-GLUCURONIC ACID
DECARBOXYLASE 1
(Homo
sapiens) 		4 / 7 ILE A 258
LEU A 323
ILE A  93
ALA A 311
 NAD  A 501 (-3.9A)
None
None
None
 0.80A 6b5vC-4lk3A:
undetectable
6b5vD-4lk3A:
undetectable		 6b5vC-4lk3A:
15.97
6b5vD-4lk3A:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_D_ECLD1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 4lk3 UDP-GLUCURONIC ACID
DECARBOXYLASE 1
(Homo
sapiens) 		4 / 7 ALA A 311
ILE A 258
LEU A 323
ILE A  93
 None
NAD  A 501 (-3.9A)
None
None
 0.78A 6b5vB-4lk3A:
undetectable
6b5vD-4lk3A:
undetectable		 6b5vB-4lk3A:
15.97
6b5vD-4lk3A:
15.97