SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lk4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 4lk4 VESB PROTEASE
(Vibrio
cholerae) 		6 / 12 HIS A  78
LEU A 122
VAL A 237
TRP A 239
GLY A 240
GLY A 251
 None
 0.64A 1etrH-4lk4A:
27.3		 1etrH-4lk4A:
27.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1002_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 4lk4 VESB PROTEASE
(Vibrio
cholerae) 		5 / 12 PHE A  80
VAL A  88
TYR A 112
SER A  66
LEU A  50
 None
 1.10A 1fm4A-4lk4A:
undetectable		 1fm4A-4lk4A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4lk4 VESB PROTEASE
(Vibrio
cholerae) 		4 / 5 SER A 366
PHE A 355
VAL A 335
PHE A 290
 None
 1.09A 1oipA-4lk4A:
undetectable		 1oipA-4lk4A:
22.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 4lk4 VESB PROTEASE
(Vibrio
cholerae) 		5 / 12 VAL A 237
TRP A 239
GLY A 240
GLY A 251
TYR A 253
 None
 0.44A 2p16A-4lk4A:
27.4		 2p16A-4lk4A:
30.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA702_0
(FERROCHELATASE)		 4lk4 VESB PROTEASE
(Vibrio
cholerae) 		3 / 3 LEU A 310
PRO A 311
ARG A 367
 None
 0.58A 2qd5A-4lk4A:
undetectable		 2qd5A-4lk4A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_D_BEZD1221_0
(PEROXIREDOXIN 6)		 4lk4 VESB PROTEASE
(Vibrio
cholerae) 		4 / 8 VAL A 226
VAL A 256
SER A 257
GLU A 232
 None
 0.88A 2v32C-4lk4A:
undetectable
2v32D-4lk4A:
undetectable		 2v32C-4lk4A:
20.91
2v32D-4lk4A:
20.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		 4lk4 VESB PROTEASE
(Vibrio
cholerae) 		5 / 12 VAL A 237
TRP A 239
GLY A 240
GLY A 251
TYR A 253
 None
 0.42A 2w26A-4lk4A:
27.6		 2w26A-4lk4A:
30.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_A_ACTA501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 4lk4 VESB PROTEASE
(Vibrio
cholerae) 		4 / 7 ASP A 241
VAL A 159
ILE A 164
TYR A 253
 None
 1.14A 2yfbA-4lk4A:
undetectable		 2yfbA-4lk4A:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_B_ACTB501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 4lk4 VESB PROTEASE
(Vibrio
cholerae) 		4 / 6 ASP A 241
VAL A 159
ILE A 164
TYR A 253
 None
 1.11A 2yfbB-4lk4A:
undetectable		 2yfbB-4lk4A:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_D_H4BD3902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4lk4 VESB PROTEASE
(Vibrio
cholerae) 		4 / 8 TRP A  44
GLU A 179
ILE A 176
TRP A 162
 None
 1.22A 3e7gC-4lk4A:
undetectable
3e7gD-4lk4A:
undetectable		 3e7gC-4lk4A:
22.83
3e7gD-4lk4A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)		 4lk4 VESB PROTEASE
(Vibrio
cholerae) 		5 / 11 HIS A  78
LEU A 122
TRP A 239
GLY A 240
GLY A 251
 None
 0.54A 3gy3A-4lk4A:
27.1		 3gy3A-4lk4A:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 4lk4 VESB PROTEASE
(Vibrio
cholerae) 		4 / 6 VAL A 237
TRP A 239
GLY A 240
GLY A 251
 None
 0.37A 3rxfA-4lk4A:
27.3		 3rxfA-4lk4A:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		 4lk4 VESB PROTEASE
(Vibrio
cholerae) 		5 / 12 GLY A 161
GLN A 178
ALA A 160
ASN A  40
ILE A 176
 None
 1.23A 4pb1A-4lk4A:
undetectable		 4pb1A-4lk4A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		 4lk4 VESB PROTEASE
(Vibrio
cholerae) 		7 / 12 HIS A  78
LEU A 122
ALA A 221
VAL A 237
TRP A 239
GLY A 240
GLY A 251
 None
 0.66A 4rn6B-4lk4A:
24.9		 4rn6B-4lk4A:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_B_ADNB301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 4lk4 VESB PROTEASE
(Vibrio
cholerae) 		5 / 9 PRO A 224
LEU A  50
ILE A 236
LEU A  74
THR A  75
 None
 1.21A 4x3mB-4lk4A:
undetectable		 4x3mB-4lk4A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA407_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 4lk4 VESB PROTEASE
(Vibrio
cholerae) 		4 / 5 ASP A 181
THR A 158
ARG A 231
GLU A 179
 None
 1.33A 5k9dA-4lk4A:
undetectable		 5k9dA-4lk4A:
21.98