SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lk5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_F_ACTF3008_0
(BETA-CARBONIC
ANHYDRASE)		 4lk5 ENOYL-COA HYDRATASE
(Mycobacterium
avium) 		4 / 8 PHE A 198
VAL A 113
GLY A  65
GLY A  64
 None
 0.89A 1ekjE-4lk5A:
undetectable
1ekjF-4lk5A:
undetectable		 1ekjE-4lk5A:
23.20
1ekjF-4lk5A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		 4lk5 ENOYL-COA HYDRATASE
(Mycobacterium
avium) 		4 / 8 ASN A 225
LEU A 232
ALA A 235
LEU A 236
 None
 0.57A 1hwiB-4lk5A:
undetectable		 1hwiB-4lk5A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		 4lk5 ENOYL-COA HYDRATASE
(Mycobacterium
avium) 		4 / 8 ASN A 225
LEU A 232
ALA A 235
LEU A 236
 None
 0.61A 1hwiD-4lk5A:
undetectable		 1hwiD-4lk5A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		 4lk5 ENOYL-COA HYDRATASE
(Mycobacterium
avium) 		4 / 8 ASN A 225
LEU A 232
ALA A 235
LEU A 236
 None
 0.60A 1hwiC-4lk5A:
undetectable		 1hwiC-4lk5A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RV7_B_AB1B1001_1
(PROTEASE)		 4lk5 ENOYL-COA HYDRATASE
(Mycobacterium
avium) 		5 / 11 ALA A 126
VAL A 114
LEU A 158
PRO A 151
VAL A 159
 None
 1.19A 1rv7A-4lk5A:
undetectable
1rv7B-4lk5A:
undetectable		 1rv7A-4lk5A:
13.84
1rv7B-4lk5A:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_P_ASDP1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4lk5 ENOYL-COA HYDRATASE
(Mycobacterium
avium) 		4 / 8 LEU A  99
ALA A 128
ALA A 112
PHE A  70
 None
 0.85A 2vcvP-4lk5A:
undetectable		 2vcvP-4lk5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4lk5 ENOYL-COA HYDRATASE
(Mycobacterium
avium) 		5 / 12 LEU A 142
GLY A 122
GLY A 120
ALA A 126
LEU A  99
 None
 1.02A 3dh0A-4lk5A:
undetectable		 3dh0A-4lk5A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4lk5 ENOYL-COA HYDRATASE
(Mycobacterium
avium) 		5 / 12 LEU A 142
GLY A 122
GLY A 120
ALA A 126
LEU A  99
 None
 0.99A 3dh0B-4lk5A:
undetectable		 3dh0B-4lk5A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		 4lk5 ENOYL-COA HYDRATASE
(Mycobacterium
avium) 		5 / 11 ASN A  35
GLY A  73
ALA A  46
GLY A  44
GLU A  50
 None
 1.31A 4a6nA-4lk5A:
undetectable		 4a6nA-4lk5A:
25.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_A_STRA601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 4lk5 ENOYL-COA HYDRATASE
(Mycobacterium
avium) 		4 / 6 ILE A  92
GLY A  75
ILE A  28
VAL A 121
 None
 0.71A 4r21A-4lk5A:
undetectable		 4r21A-4lk5A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_2
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 4lk5 ENOYL-COA HYDRATASE
(Mycobacterium
avium) 		4 / 4 VAL A 245
LEU A 246
LEU A 149
ASP A 152
 None
 1.24A 5xv7A-4lk5A:
undetectable		 5xv7A-4lk5A:
15.09