SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ll6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ8_B_CAMB502_0
(CYTOCHROME P450-CAM)		 4ll6 MYOSIN-4
(Saccharomyces
cerevisiae) 		5 / 9 PHE A1162
THR A1169
GLY A1121
THR A1456
VAL A1142
 None
 1.30A 1dz8B-4ll6A:
undetectable		 1dz8B-4ll6A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ9_B_CAMB502_0
(CYTOCHROME P450-CAM)		 4ll6 MYOSIN-4
(Saccharomyces
cerevisiae) 		5 / 9 PHE A1162
THR A1169
GLY A1121
THR A1456
VAL A1142
 None
 1.27A 1dz9B-4ll6A:
undetectable		 1dz9B-4ll6A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN)		 4ll6 MYOSIN-4
(Saccharomyces
cerevisiae) 		5 / 11 ILE A1163
THR A1230
LEU A1226
VAL A1146
PHE A1199
 None
 1.28A 1tw4A-4ll6A:
undetectable		 1tw4A-4ll6A:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_2
(MINERALOCORTICOID
RECEPTOR)		 4ll6 MYOSIN-4
(Saccharomyces
cerevisiae) 		3 / 3 LEU A1231
LEU A1193
MET A1296
 None
 0.79A 1ya3B-4ll6A:
undetectable		 1ya3B-4ll6A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_D_IMND476_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 4ll6 MYOSIN-4
(Saccharomyces
cerevisiae) 		5 / 12 THR A1144
ILE A1163
VAL A1166
ILE A1140
VAL A1147
 None
 1.06A 1z9hD-4ll6A:
2.1		 1z9hD-4ll6A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4ll6 MYOSIN-4
(Saccharomyces
cerevisiae) 		3 / 3 LYS A1272
ASP A1315
CYH A1320
 None
 1.39A 2br4F-4ll6A:
undetectable		 2br4F-4ll6A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_A_P1ZA2001_1
(SERUM ALBUMIN)		 4ll6 MYOSIN-4
(Saccharomyces
cerevisiae) 		5 / 12 LEU A1413
ALA A1359
ILE A1362
ILE A1391
ALA A1390
 None
None
ACY  A1502 ( 4.7A)
None
None
 0.89A 2bxcA-4ll6A:
undetectable		 2bxcA-4ll6A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA701_0
(FERROCHELATASE)		 4ll6 MYOSIN-4
(Saccharomyces
cerevisiae) 		5 / 12 LEU A1305
PHE A1342
LEU A1353
LEU A1260
VAL A1331
 None
 1.21A 2hrcA-4ll6A:
undetectable		 2hrcA-4ll6A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1605_0
(FERROCHELATASE)		 4ll6 MYOSIN-4
(Saccharomyces
cerevisiae) 		5 / 12 LEU A1305
PHE A1342
LEU A1353
LEU A1260
VAL A1331
 None
 1.17A 2hrcB-4ll6A:
undetectable		 2hrcB-4ll6A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1200_1
(SERUM ALBUMIN)		 4ll6 MYOSIN-4
(Saccharomyces
cerevisiae) 		4 / 4 LEU A1413
ILE A1362
ILE A1391
ALA A1390
 None
ACY  A1502 ( 4.7A)
None
None
 0.78A 2i30A-4ll6A:
undetectable		 2i30A-4ll6A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_D_SC2D1290_1
(FICOLIN-2)		 4ll6 MYOSIN-4
(Saccharomyces
cerevisiae) 		4 / 5 GLY A1185
TRP A1189
TRP A1241
LEU A1177
 None
 1.39A 2j2pD-4ll6A:
undetectable
2j2pF-4ll6A:
undetectable		 2j2pD-4ll6A:
20.37
2j2pF-4ll6A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1003_0
(ALDEHYDE
DEHYDROGENASE A)		 4ll6 MYOSIN-4
(Saccharomyces
cerevisiae) 		4 / 5 ILE A1253
LEU A1276
ALA A1249
PHE A1342
 None
 0.78A 2opxA-4ll6A:
undetectable		 2opxA-4ll6A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_A_ACTA1397_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 4ll6 MYOSIN-4
(Saccharomyces
cerevisiae) 		3 / 3 PRO A1397
GLY A1404
TYR A1395
 None
 0.72A 2vouA-4ll6A:
undetectable		 2vouA-4ll6A:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		 4ll6 MYOSIN-4
(Saccharomyces
cerevisiae) 		3 / 3 SER A1194
THR A1230
PHE A1162
 None
 0.66A 2x91A-4ll6A:
undetectable		 2x91A-4ll6A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		 4ll6 MYOSIN-4
(Saccharomyces
cerevisiae) 		4 / 8 LEU A1305
LYS A1306
ASN A1309
LEU A1312
 None
 0.41A 2xn3A-4ll6A:
undetectable
2xn3B-4ll6A:
undetectable		 2xn3A-4ll6A:
22.50
2xn3B-4ll6A:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		 4ll6 MYOSIN-4
(Saccharomyces
cerevisiae) 		5 / 11 LEU A1338
LEU A1305
LYS A1306
ASN A1309
LEU A1312
 None
 0.80A 2xn5A-4ll6A:
undetectable		 2xn5A-4ll6A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 4ll6 MYOSIN-4
(Saccharomyces
cerevisiae) 		5 / 12 PHE A1234
ILE A1237
VAL A1233
LEU A1242
VAL A1174
 None
 1.20A 3fpjB-4ll6A:
undetectable		 3fpjB-4ll6A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ1_X_DXCX75_0
(CYTOCHROME C7)		 4ll6 MYOSIN-4
(Saccharomyces
cerevisiae) 		4 / 6 ILE A1362
LEU A1383
PHE A1313
MET A1431
 ACY  A1502 ( 4.7A)
None
None
None
 1.05A 3sj1X-4ll6A:
undetectable		 3sj1X-4ll6A:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RMJ_A_NCAA402_0
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2)		 4ll6 MYOSIN-4
(Saccharomyces
cerevisiae) 		4 / 7 ILE A1356
LEU A1305
LEU A1338
ILE A1255
 None
 0.79A 4rmjA-4ll6A:
undetectable		 4rmjA-4ll6A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_A_QI9A602_0
(CYTOCHROME P450 2D6)		 4ll6 MYOSIN-4
(Saccharomyces
cerevisiae) 		5 / 9 LEU A1226
SER A1164
THR A1115
VAL A1147
LEU A1111
 None
 1.42A 4wnvA-4ll6A:
undetectable		 4wnvA-4ll6A:
22.47