SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ll8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOS_A_VIAA1_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 4ll8 MYOSIN-4
(Saccharomyces
cerevisiae) 		5 / 12 LEU A1305
PHE A1283
SER A1288
PHE A1342
ILE A1346
 None
 1.48A 1xosA-4ll8A:
undetectable		 1xosA-4ll8A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_2
(MINERALOCORTICOID
RECEPTOR)		 4ll8 MYOSIN-4
(Saccharomyces
cerevisiae) 		3 / 3 LEU A1231
LEU A1193
MET A1296
 None
 0.82A 1ya3B-4ll8A:
undetectable		 1ya3B-4ll8A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_C_STRC3001_1
(MINERALOCORTICOID
RECEPTOR)		 4ll8 MYOSIN-4
(Saccharomyces
cerevisiae) 		5 / 12 LEU A1196
LEU A1193
LEU A1190
LEU A1123
THR A1144
 None
 1.05A 1ya3C-4ll8A:
undetectable		 1ya3C-4ll8A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_D_IMND476_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 4ll8 MYOSIN-4
(Saccharomyces
cerevisiae) 		5 / 12 THR A1144
ILE A1163
VAL A1166
ILE A1140
VAL A1147
 None
 1.15A 1z9hD-4ll8A:
undetectable		 1z9hD-4ll8A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_A_P1ZA2001_1
(SERUM ALBUMIN)		 4ll8 MYOSIN-4
(Saccharomyces
cerevisiae) 		5 / 12 LEU A1413
ALA A1359
ILE A1362
ILE A1391
ALA A1390
 None
 1.08A 2bxcA-4ll8A:
undetectable		 2bxcA-4ll8A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_B_ERYB1399_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 4ll8 MYOSIN-4
(Saccharomyces
cerevisiae) 		5 / 12 ASN A1334
VAL A1331
ILE A1357
LEU A1305
ALA A1359
 None
 1.37A 2iyfB-4ll8A:
undetectable		 2iyfB-4ll8A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4ll8 MYOSIN-4
(Saccharomyces
cerevisiae) 		5 / 12 LEU A1305
PHE A1342
LEU A1353
LEU A1260
VAL A1331
 None
 1.17A 2po7B-4ll8A:
undetectable		 2po7B-4ll8A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		 4ll8 MYOSIN-4
(Saccharomyces
cerevisiae) 		3 / 3 SER A1194
THR A1230
PHE A1162
 None
 0.69A 2x91A-4ll8A:
undetectable		 2x91A-4ll8A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		 4ll8 MYOSIN-4
(Saccharomyces
cerevisiae) 		4 / 8 LEU A1305
LYS A1306
ASN A1309
LEU A1312
 None
 0.56A 2xn3A-4ll8A:
undetectable
2xn3B-4ll8A:
undetectable		 2xn3A-4ll8A:
21.08
2xn3B-4ll8A:
6.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		 4ll8 SWI5-DEPENDENT HO
EXPRESSION PROTEIN 3
(Saccharomyces
cerevisiae) 		4 / 8 LEU E  70
LYS E  71
ASN E  74
LEU E  77
 None
 0.62A 2xn3A-4ll8E:
undetectable
2xn3B-4ll8E:
undetectable		 2xn3A-4ll8E:
22.91
2xn3B-4ll8E:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		 4ll8 MYOSIN-4
(Saccharomyces
cerevisiae) 		5 / 11 LEU A1338
LEU A1305
LYS A1306
ASN A1309
LEU A1312
 None
 0.92A 2xn5A-4ll8A:
undetectable		 2xn5A-4ll8A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA5_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 4ll8 MYOSIN-4
SWI5-DEPENDENT HO
EXPRESSION PROTEIN 3
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 LYS A1326
SER E 127
GLN E 131
 None
 1.26A 3si7A-4ll8A:
undetectable		 3si7A-4ll8A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_2
(ADENOSINE KINASE,
PUTATIVE)		 4ll8 MYOSIN-4
(Saccharomyces
cerevisiae) 		4 / 5 LEU A1137
GLY A1138
PHE A1290
ASN A1132
 None
 1.03A 3uq6B-4ll8A:
undetectable		 3uq6B-4ll8A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4ll8 MYOSIN-4
SWI5-DEPENDENT HO
EXPRESSION PROTEIN 3
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 12 VAL E 135
LEU E 140
SER E 143
PHE A1379
ILE A1391
 None
 0.91A 3w67D-4ll8E:
undetectable		 3w67D-4ll8E:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4ll8 MYOSIN-4
SWI5-DEPENDENT HO
EXPRESSION PROTEIN 3
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 12 VAL E 135
SER E 139
LEU E 140
SER E 143
PHE A1379
 None
 1.04A 3w68A-4ll8E:
undetectable		 3w68A-4ll8E:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_2
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 4ll8 MYOSIN-4
(Saccharomyces
cerevisiae) 		3 / 3 LYS A1464
THR A1145
ILE A1140
 None
 0.93A 4e0fB-4ll8A:
undetectable		 4e0fB-4ll8A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4ll8 MYOSIN-4
(Saccharomyces
cerevisiae) 		4 / 6 PHE A1283
MET A1183
ARG A1345
VAL A1292
 None
 1.42A 4mk4B-4ll8A:
undetectable		 4mk4B-4ll8A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_A_29SA601_1
(ESTROGEN RECEPTOR)		 4ll8 MYOSIN-4
(Saccharomyces
cerevisiae) 		5 / 12 ASP A1225
GLU A1227
LEU A1223
LEU A1443
LEU A1167
 None
 1.14A 4xi3A-4ll8A:
undetectable		 4xi3A-4ll8A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA504_1
(-)		 4ll8 MYOSIN-4
(Saccharomyces
cerevisiae) 		5 / 8 ILE A1163
VAL A1151
GLU A1208
ALA A1201
LEU A1223
 None
 1.09A 5og9A-4ll8A:
1.8		 5og9A-4ll8A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 4ll8 MYOSIN-4
(Saccharomyces
cerevisiae) 		4 / 5 LEU A1305
PHE A1301
PHE A1342
LEU A1338
 None
 1.11A 5x1bP-4ll8A:
2.8		 5x1bP-4ll8A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_B_CHDB401_0
(BILE SALT HYDROLASE)		 4ll8 MYOSIN-4
(Saccharomyces
cerevisiae) 		5 / 10 LEU A1363
ILE A1335
LEU A1353
LEU A1432
LEU A1383
 None
 0.97A 5y7pB-4ll8A:
undetectable		 5y7pB-4ll8A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_D_CHDD401_0
(BILE SALT HYDROLASE)		 4ll8 MYOSIN-4
(Saccharomyces
cerevisiae) 		5 / 10 LEU A1363
ILE A1335
LEU A1353
LEU A1432
LEU A1383
 None
 0.92A 5y7pD-4ll8A:
undetectable		 5y7pD-4ll8A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_G_CHDG401_0
(BILE SALT HYDROLASE)		 4ll8 MYOSIN-4
(Saccharomyces
cerevisiae) 		5 / 10 LEU A1363
ILE A1335
LEU A1312
LEU A1432
LEU A1383
 None
 0.83A 5y7pG-4ll8A:
undetectable		 5y7pG-4ll8A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_H_CHDH401_0
(BILE SALT HYDROLASE)		 4ll8 MYOSIN-4
(Saccharomyces
cerevisiae) 		5 / 10 LEU A1363
ILE A1335
LEU A1353
LEU A1432
LEU A1383
 None
 0.99A 5y7pH-4ll8A:
undetectable		 5y7pH-4ll8A:
20.94