SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lls'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4002_1
(SERUM ALBUMIN)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		4 / 4 ARG A 255
ALA A 211
ALA A 263
GLU A 262
 None
 1.16A 1e7bA-4llsA:
undetectable		 1e7bA-4llsA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4002_1
(SERUM ALBUMIN)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		4 / 4 ARG A 255
ALA A 211
ALA A 263
GLU A 262
 None
 1.06A 1e7bB-4llsA:
undetectable		 1e7bB-4llsA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_A_CCSA47_0
(GLUTATHIONE
S-TRANSFERASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		4 / 7 LEU A 208
LEU A 182
GLY A 184
LEU A  47
 None
 0.92A 1gtiA-4llsA:
undetectable		 1gtiA-4llsA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_J_SAMJ200_0
(METHIONINE REPRESSOR)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 12 GLY A 184
ARG A 255
LEU A 259
GLU A 262
ALA A 263
 None
 1.09A 1mjqI-4llsA:
undetectable
1mjqJ-4llsA:
undetectable		 1mjqI-4llsA:
18.61
1mjqJ-4llsA:
18.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 11 SER A  76
LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
LYS A 230
 GST  A 302 (-3.9A)
None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
GST  A 302 (-2.7A)
 0.65A 1rqjA-4llsA:
42.4		 1rqjA-4llsA:
42.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		9 / 11 SER A  76
LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
ASP A 216
LYS A 230
 GST  A 302 (-3.9A)
None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.57A 1rqjA-4llsA:
42.4		 1rqjA-4llsA:
42.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		9 / 11 SER A  76
LEU A  77
ASP A  80
ASP A  86
ARG A  91
THR A 179
GLN A 213
ASP A 216
LYS A 230
 GST  A 302 (-3.9A)
None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.66A 1rqjA-4llsA:
42.4		 1rqjA-4llsA:
42.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 11 SER A  76
LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
LYS A 230
 GST  A 302 (-3.9A)
None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
GST  A 302 (-2.7A)
 0.70A 1rqjB-4llsA:
42.2		 1rqjB-4llsA:
42.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		10 / 11 SER A  76
LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 GST  A 302 (-3.9A)
None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.70A 1rqjB-4llsA:
42.2		 1rqjB-4llsA:
42.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_B_CHDB4085_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE II
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 MET A 149
GLY A 148
GLN A 175
ARG A  44
GLY A 184
 GST  A 302 ( 4.1A)
None
None
IPE  A 301 (-3.1A)
None
 1.30A 1v54A-4llsA:
0.6
1v54B-4llsA:
undetectable
1v54T-4llsA:
undetectable		 1v54A-4llsA:
20.31
1v54B-4llsA:
22.93
1v54T-4llsA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YHL_A_RISA1400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 11 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.75A 1yhlA-4llsA:
28.9		 1yhlA-4llsA:
26.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YHL_A_RISA1400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		8 / 11 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.62A 1yhlA-4llsA:
28.9		 1yhlA-4llsA:
26.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YHL_A_RISA1400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		8 / 11 LEU A  77
ASP A  80
ASP A  86
ARG A  91
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.58A 1yhlA-4llsA:
28.9		 1yhlA-4llsA:
26.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		8 / 11 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
LYS A 178
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
GST  A 302 (-3.4A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.86A 1yq7A-4llsA:
28.6		 1yq7A-4llsA:
28.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		8 / 11 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.69A 1yq7A-4llsA:
28.6		 1yq7A-4llsA:
28.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		8 / 11 LEU A  77
ASP A  80
ASP A  86
ARG A  91
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.69A 1yq7A-4llsA:
28.6		 1yq7A-4llsA:
28.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.69A 1yv5A-4llsA:
28.7		 1yv5A-4llsA:
28.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		9 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.67A 1yv5A-4llsA:
28.7		 1yv5A-4llsA:
28.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZW5_A_ZOLA901_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		6 / 9 ASP A  80
ASP A  86
ARG A  91
GLN A 153
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.77A 1zw5A-4llsA:
29.5		 1zw5A-4llsA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZW5_A_ZOLA901_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		8 / 9 ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.74A 1zw5A-4llsA:
29.5		 1zw5A-4llsA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 12 LEU A 277
LEU A  47
TYR A 204
ALA A 191
ALA A 196
 None
 1.15A 2bm9A-4llsA:
undetectable		 2bm9A-4llsA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 12 LEU A 277
LEU A  47
TYR A 204
ALA A 191
ALA A 196
 None
 1.15A 2bm9C-4llsA:
undetectable		 2bm9C-4llsA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 12 LEU A 277
LEU A  47
TYR A 204
ALA A 191
ALA A 196
 None
 1.18A 2bm9D-4llsA:
undetectable		 2bm9D-4llsA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_A_ZOLA901_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 9 ASP A  80
ASP A  86
ARG A  91
GLN A 153
ASP A 216
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
CA  A 303 (-2.9A)
 0.67A 2e91A-4llsA:
21.3		 2e91A-4llsA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_A_ZOLA901_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		6 / 9 ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
ASP A 216
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
CA  A 303 (-2.9A)
 0.69A 2e91A-4llsA:
21.3		 2e91A-4llsA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_A_ZOLA901_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		6 / 9 ASP A  80
ASP A  86
ARG A  91
THR A 179
GLN A 213
ASP A 216
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
 0.68A 2e91A-4llsA:
21.3		 2e91A-4llsA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_B_ZOLB902_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 9 ASP A  80
ASP A  86
ARG A  91
GLN A 153
LYS A 178
THR A 179
ASP A 216
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
CA  A 303 (-2.9A)
 0.86A 2e91B-4llsA:
20.5		 2e91B-4llsA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_B_ZOLB902_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		6 / 9 ASP A  80
ASP A  86
ARG A  91
THR A 179
GLN A 213
ASP A 216
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
 0.75A 2e91B-4llsA:
20.5		 2e91B-4llsA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_N_CHDN1604_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 ARG A  44
GLY A 184
MET A 149
GLY A 148
GLN A 175
 IPE  A 301 (-3.1A)
None
GST  A 302 ( 4.1A)
None
None
 1.36A 2eimG-4llsA:
undetectable
2eimN-4llsA:
0.9
2eimO-4llsA:
undetectable		 2eimG-4llsA:
14.29
2eimN-4llsA:
20.31
2eimO-4llsA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EZ7_A_DHIA301_0
(CARBONIC ANHYDRASE 2)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		4 / 6 HIS A  98
ASN A  87
THR A  96
PRO A  95
 None
 1.43A 2ez7A-4llsA:
undetectable		 2ez7A-4llsA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F89_F_210F9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		8 / 9 ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.65A 2f89F-4llsA:
30.3		 2f89F-4llsA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8C_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 11 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.70A 2f8cF-4llsA:
29.6		 2f8cF-4llsA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8C_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		9 / 11 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.69A 2f8cF-4llsA:
29.6		 2f8cF-4llsA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8Z_F_ZOLF5001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		8 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
LYS A 178
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
GST  A 302 (-3.4A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.77A 2f8zF-4llsA:
30.3		 2f8zF-4llsA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8Z_F_ZOLF5001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		9 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.69A 2f8zF-4llsA:
30.3		 2f8zF-4llsA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F94_F_BFQF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		10 / 12 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.63A 2f94F-4llsA:
29.3		 2f94F-4llsA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9K_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.72A 2f9kF-4llsA:
29.2		 2f9kF-4llsA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9K_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		9 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.70A 2f9kF-4llsA:
29.2		 2f9kF-4llsA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_1
(VITAMIN D RECEPTOR)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 12 LEU A 182
SER A 144
VAL A  48
LEU A 193
LEU A 201
 None
 1.32A 2hc4A-4llsA:
2.3		 2hc4A-4llsA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_A_RISA400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 9 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
 0.63A 2o1oA-4llsA:
24.8		 2o1oA-4llsA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_A_RISA400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		6 / 9 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
 0.53A 2o1oA-4llsA:
24.8		 2o1oA-4llsA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_A_RISA400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 9 LEU A  77
ASP A  86
ARG A  91
THR A 179
GLN A 213
 None
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
 0.73A 2o1oA-4llsA:
24.8		 2o1oA-4llsA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_B_RISB400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
 0.59A 2o1oB-4llsA:
25.6		 2o1oB-4llsA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_B_RISB400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		6 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
 0.65A 2o1oB-4llsA:
25.6		 2o1oB-4llsA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_B_RISB400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		6 / 10 LEU A  77
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
 None
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
 0.82A 2o1oB-4llsA:
25.6		 2o1oB-4llsA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 10 LEU A  77
ASP A  80
ARG A  91
GLN A 153
ASP A 235
 None
CA  A 304 ( 2.9A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
CA  A 303 ( 4.3A)
 1.08A 2q58A-4llsA:
25.2		 2q58A-4llsA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
ASP A 220
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
None
 1.38A 2q58A-4llsA:
25.2		 2q58A-4llsA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
 0.94A 2q58A-4llsA:
25.2		 2q58A-4llsA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
 0.95A 2q58A-4llsA:
25.2		 2q58A-4llsA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		6 / 10 LEU A  77
ASP A  86
ARG A  91
THR A 179
GLN A 213
ASP A 217
 None
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
None
 0.89A 2q58A-4llsA:
25.2		 2q58A-4llsA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_B_ZOLB2_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 9 ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
 0.66A 2q58B-4llsA:
25.2		 2q58B-4llsA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_B_ZOLB2_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 9 ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
 CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
 0.86A 2q58B-4llsA:
25.2		 2q58B-4llsA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QIS_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.73A 2qisA-4llsA:
29.0		 2qisA-4llsA:
29.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QIS_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		8 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.67A 2qisA-4llsA:
29.0		 2qisA-4llsA:
29.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 12 LEU A 182
SER A 144
VAL A  48
LEU A 193
LEU A 201
 None
 1.28A 2zlcA-4llsA:
undetectable		 2zlcA-4llsA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_G_CHDG86_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 6A2
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 ARG A  44
GLY A 184
MET A 149
GLY A 148
GLN A 175
 IPE  A 301 (-3.1A)
None
GST  A 302 ( 4.1A)
None
None
 1.32A 2zxwG-4llsA:
undetectable
2zxwN-4llsA:
1.3
2zxwO-4llsA:
undetectable		 2zxwG-4llsA:
14.29
2zxwN-4llsA:
20.31
2zxwO-4llsA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_B_CHDB1085_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 MET A 149
GLN A 175
THR A 172
ARG A  44
GLY A 184
 GST  A 302 ( 4.1A)
None
None
IPE  A 301 (-3.1A)
None
 1.48A 3abkA-4llsA:
2.0
3abkB-4llsA:
undetectable
3abkT-4llsA:
undetectable		 3abkA-4llsA:
20.31
3abkB-4llsA:
22.93
3abkT-4llsA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_B_CHDB1085_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 MET A 149
GLN A 175
THR A 172
ARG A  44
GLY A 184
 GST  A 302 ( 4.1A)
None
None
IPE  A 301 (-3.1A)
None
 1.41A 3ag3A-4llsA:
0.8
3ag3B-4llsA:
undetectable
3ag3T-4llsA:
undetectable		 3ag3A-4llsA:
20.31
3ag3B-4llsA:
22.93
3ag3T-4llsA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_B_CHDB1085_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 MET A 149
GLY A 148
GLN A 175
ARG A  44
GLY A 184
 GST  A 302 ( 4.1A)
None
None
IPE  A 301 (-3.1A)
None
 1.13A 3ag3A-4llsA:
0.8
3ag3B-4llsA:
undetectable
3ag3T-4llsA:
undetectable		 3ag3A-4llsA:
20.31
3ag3B-4llsA:
22.93
3ag3T-4llsA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_O_CHDO229_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 ARG A  44
GLY A 184
MET A 149
GLY A 148
GLN A 175
 IPE  A 301 (-3.1A)
None
GST  A 302 ( 4.1A)
None
None
 1.18A 3ag3G-4llsA:
undetectable
3ag3N-4llsA:
1.9
3ag3O-4llsA:
undetectable		 3ag3G-4llsA:
14.29
3ag3N-4llsA:
20.31
3ag3O-4llsA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_B_CHDB1085_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 12 MET A 149
GLY A 177
GLN A 175
ARG A  44
GLY A 184
 GST  A 302 ( 4.1A)
None
None
IPE  A 301 (-3.1A)
None
 1.41A 3ag4A-4llsA:
1.3
3ag4B-4llsA:
undetectable
3ag4T-4llsA:
undetectable		 3ag4A-4llsA:
20.31
3ag4B-4llsA:
22.93
3ag4T-4llsA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_A_MXDA551_1
(PROSTACYCLIN
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		4 / 6 ALA A 137
LEU A 140
ALA A  68
THR A  67
 None
 0.91A 3b6hA-4llsA:
2.3		 3b6hA-4llsA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_B_MXDB551_1
(PROSTACYCLIN
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		4 / 6 ALA A 137
LEU A 140
ALA A  68
THR A  67
 None
 0.91A 3b6hB-4llsA:
2.5		 3b6hB-4llsA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_2
(PHOSPHOLIPASE A2)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		4 / 5 VAL A 284
VAL A 285
THR A 179
THR A 280
 None
None
IPE  A 301 (-4.2A)
None
 1.22A 3bjwD-4llsA:
1.3		 3bjwD-4llsA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 9 ASP A  80
ARG A  91
GLN A 213
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
GST  A 302 (-2.9A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 1.12A 3ez3A-4llsA:
28.4		 3ez3A-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		6 / 9 ASP A  80
ASP A  86
ARG A  91
GLN A 153
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.93A 3ez3A-4llsA:
28.4		 3ez3A-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 9 ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.73A 3ez3A-4llsA:
28.4		 3ez3A-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 9 ASP A  80
ASP A  86
ARG A  91
THR A 179
GLN A 213
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.76A 3ez3A-4llsA:
28.4		 3ez3A-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 9 ASP A  80
ARG A  91
GLN A 213
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
GST  A 302 (-2.9A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 1.15A 3ez3B-4llsA:
28.3		 3ez3B-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		6 / 9 ASP A  80
ASP A  86
ARG A  91
GLN A 153
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.81A 3ez3B-4llsA:
28.3		 3ez3B-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 9 ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.66A 3ez3B-4llsA:
28.3		 3ez3B-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 9 ASP A  80
ASP A  86
ARG A  91
THR A 179
GLN A 213
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.68A 3ez3B-4llsA:
28.3		 3ez3B-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 9 ASP A  80
ARG A  91
GLN A 213
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
GST  A 302 (-2.9A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 1.11A 3ez3C-4llsA:
27.8		 3ez3C-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		6 / 9 ASP A  80
ASP A  86
ARG A  91
GLN A 153
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.89A 3ez3C-4llsA:
27.8		 3ez3C-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 9 ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.74A 3ez3C-4llsA:
27.8		 3ez3C-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 9 ASP A  80
ASP A  86
ARG A  91
THR A 179
GLN A 213
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.78A 3ez3C-4llsA:
27.8		 3ez3C-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		6 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
GST  A 302 (-2.7A)
 0.65A 3ez3D-4llsA:
28.2		 3ez3D-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		8 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.63A 3ez3D-4llsA:
28.2		 3ez3D-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		8 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.65A 3ez3D-4llsA:
28.2		 3ez3D-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IBA_A_ZOLA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		6 / 10 ASP A  80
ASP A  86
ARG A  91
GLN A 153
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.82A 3ibaA-4llsA:
28.8		 3ibaA-4llsA:
26.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IBA_A_ZOLA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		8 / 10 ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.72A 3ibaA-4llsA:
28.8		 3ibaA-4llsA:
26.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 9 ASP A  80
ARG A  91
GLN A 213
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
GST  A 302 (-2.9A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 1.11A 3ldwA-4llsA:
28.3		 3ldwA-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		6 / 9 ASP A  80
ASP A  86
ARG A  91
GLN A 153
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.94A 3ldwA-4llsA:
28.3		 3ldwA-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 9 ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.75A 3ldwA-4llsA:
28.3		 3ldwA-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 9 ASP A  80
ASP A  86
ARG A  91
THR A 179
GLN A 213
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.78A 3ldwA-4llsA:
28.3		 3ldwA-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 9 ASP A  80
ARG A  91
GLN A 213
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
GST  A 302 (-2.9A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 1.20A 3ldwB-4llsA:
28.3		 3ldwB-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		6 / 9 ASP A  80
ASP A  86
ARG A  91
GLN A 153
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.83A 3ldwB-4llsA:
28.3		 3ldwB-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 9 ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.69A 3ldwB-4llsA:
28.3		 3ldwB-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 9 ASP A  80
ASP A  86
ARG A  91
THR A 179
GLN A 213
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.71A 3ldwB-4llsA:
28.3		 3ldwB-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		6 / 9 ASP A  80
ASP A  86
ARG A  91
GLN A 153
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.90A 3ldwC-4llsA:
28.3		 3ldwC-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 9 ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.73A 3ldwC-4llsA:
28.3		 3ldwC-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 9 ASP A  80
ASP A  86
ARG A  91
THR A 179
GLN A 213
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.77A 3ldwC-4llsA:
28.3		 3ldwC-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		6 / 9 ASP A  80
ASP A  86
ARG A  91
GLN A 153
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.82A 3ldwD-4llsA:
28.2		 3ldwD-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 9 ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.68A 3ldwD-4llsA:
28.2		 3ldwD-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 9 ASP A  80
ASP A  86
ARG A  91
THR A 179
GLN A 213
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.70A 3ldwD-4llsA:
28.2		 3ldwD-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 THR A  67
ALA A  68
VAL A  48
ALA A  59
GLY A  60
 None
 0.96A 3mg0K-4llsA:
undetectable
3mg0L-4llsA:
undetectable		 3mg0K-4llsA:
19.87
3mg0L-4llsA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N45_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 11 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.73A 3n45F-4llsA:
29.2		 3n45F-4llsA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N45_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		9 / 11 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.71A 3n45F-4llsA:
29.2		 3n45F-4llsA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N46_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.74A 3n46F-4llsA:
29.0		 3n46F-4llsA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N46_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		9 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.71A 3n46F-4llsA:
29.0		 3n46F-4llsA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_C_BEZC264_0
(CARNITINYL-COA
DEHYDRATASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		4 / 6 ALA A  66
ILE A  63
LEU A  49
ALA A 189
 None
 0.81A 3r9sC-4llsA:
undetectable		 3r9sC-4llsA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 12 GLN A 213
ASP A  80
LEU A 151
GLY A 177
ALA A 154
 IPE  A 301 ( 4.1A)
CA  A 304 ( 2.9A)
None
None
None
 1.05A 3sufA-4llsA:
undetectable		 3sufA-4llsA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 MET A 149
GLY A 177
GLN A 175
ARG A  44
GLY A 184
 GST  A 302 ( 4.1A)
None
None
IPE  A 301 (-3.1A)
None
 1.45A 3wg7A-4llsA:
2.0
3wg7B-4llsA:
undetectable
3wg7T-4llsA:
undetectable		 3wg7A-4llsA:
20.31
3wg7B-4llsA:
22.93
3wg7T-4llsA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 MET A 149
GLY A 177
GLN A 175
ARG A  44
GLY A 184
 GST  A 302 ( 4.1A)
None
None
IPE  A 301 (-3.1A)
None
 1.47A 3x2qA-4llsA:
0.6
3x2qB-4llsA:
undetectable
3x2qT-4llsA:
undetectable		 3x2qA-4llsA:
20.31
3x2qB-4llsA:
22.93
3x2qT-4llsA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K87_A_ADNA602_1
(PROLINE--TRNA LIGASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		4 / 8 GLY A 190
THR A  51
THR A 198
ARG A 192
 None
 1.00A 4k87A-4llsA:
undetectable		 4k87A-4llsA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFA_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		8 / 9 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
LYS A 178
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
GST  A 302 (-3.4A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.81A 4kfaA-4llsA:
29.1		 4kfaA-4llsA:
29.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFA_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 9 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.63A 4kfaA-4llsA:
29.1		 4kfaA-4llsA:
29.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPD_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.74A 4kpdA-4llsA:
30.3		 4kpdA-4llsA:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPD_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		9 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.69A 4kpdA-4llsA:
30.3		 4kpdA-4llsA:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPJ_A_210A901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		9 / 9 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.71A 4kpjA-4llsA:
29.2		 4kpjA-4llsA:
29.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ5_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 10 ASP A  80
ARG A  91
GLN A 213
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
GST  A 302 (-2.9A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 1.21A 4kq5A-4llsA:
29.2		 4kq5A-4llsA:
29.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ5_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.77A 4kq5A-4llsA:
29.2		 4kq5A-4llsA:
29.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ5_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		9 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.76A 4kq5A-4llsA:
29.2		 4kq5A-4llsA:
29.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQS_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.72A 4kqsA-4llsA:
30.3		 4kqsA-4llsA:
29.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQS_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		9 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.68A 4kqsA-4llsA:
30.3		 4kqsA-4llsA:
29.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.75A 4n9uA-4llsA:
29.0		 4n9uA-4llsA:
29.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		8 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.62A 4n9uA-4llsA:
29.0		 4n9uA-4llsA:
29.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 12 ASP A  80
ARG A  91
GLN A 213
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
GST  A 302 (-2.9A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 1.19A 4ng6A-4llsA:
29.7		 4ng6A-4llsA:
29.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		9 / 12 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.62A 4ng6A-4llsA:
29.7		 4ng6A-4llsA:
29.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKE_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.78A 4nkeA-4llsA:
29.0		 4nkeA-4llsA:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKE_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		8 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.69A 4nkeA-4llsA:
29.0		 4nkeA-4llsA:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKE_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		8 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.69A 4nkeA-4llsA:
29.0		 4nkeA-4llsA:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKF_A_210A404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		9 / 9 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.66A 4nkfA-4llsA:
29.3		 4nkfA-4llsA:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.84A 4nuaA-4llsA:
29.4		 4nuaA-4llsA:
29.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		9 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.79A 4nuaA-4llsA:
29.4		 4nuaA-4llsA:
29.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGU_A_210A405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		9 / 9 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.70A 4oguA-4llsA:
29.1		 4oguA-4llsA:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0V_A_ZOLA401_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		6 / 9 ASP A  80
ASP A  86
ARG A  91
GLN A 153
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.74A 4p0vA-4llsA:
30.2		 4p0vA-4llsA:
25.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0V_A_ZOLA401_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		8 / 9 ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.75A 4p0vA-4llsA:
30.2		 4p0vA-4llsA:
25.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0W_A_ZOLA501_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 ASP A  80
ARG A  91
GLN A 213
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
GST  A 302 (-2.9A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 1.18A 4p0wA-4llsA:
30.0		 4p0wA-4llsA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0W_A_ZOLA501_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 11 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.74A 4p0wA-4llsA:
30.0		 4p0wA-4llsA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0W_A_ZOLA501_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		9 / 11 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.74A 4p0wA-4llsA:
30.0		 4p0wA-4llsA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q23_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		8 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
LYS A 178
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
GST  A 302 (-3.4A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.79A 4q23A-4llsA:
28.7		 4q23A-4llsA:
29.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q23_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		8 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.70A 4q23A-4llsA:
28.7		 4q23A-4llsA:
29.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 12 ARG A 203
TYR A 204
SER A 266
LEU A 267
LEU A  54
 None
 1.27A 4qztC-4llsA:
undetectable		 4qztC-4llsA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_A_RISA1404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.75A 4rxdA-4llsA:
27.7		 4rxdA-4llsA:
27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_A_RISA1404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		9 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.69A 4rxdA-4llsA:
27.7		 4rxdA-4llsA:
27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_B_RISB1504_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.73A 4rxdB-4llsA:
28.0		 4rxdB-4llsA:
27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_B_RISB1504_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		9 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.68A 4rxdB-4llsA:
28.0		 4rxdB-4llsA:
27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_C_RISC1600_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.74A 4rxdC-4llsA:
28.0		 4rxdC-4llsA:
27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_C_RISC1600_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		9 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.68A 4rxdC-4llsA:
28.0		 4rxdC-4llsA:
27.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UMJ_A_BFQA1297_1
(GERANYLTRANSTRANSFER
ASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		8 / 8 SER A  76
LEU A  77
ASP A  80
ASP A  86
ARG A  91
MET A 149
GLN A 153
LYS A 178
 GST  A 302 (-3.9A)
None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 ( 4.1A)
GST  A 302 (-3.7A)
GST  A 302 (-3.4A)
 0.35A 4umjA-4llsA:
34.9		 4umjA-4llsA:
43.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UMJ_B_BFQB1294_1
(GERANYLTRANSTRANSFER
ASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		9 / 9 SER A  76
LEU A  77
ASP A  80
ASP A  86
ARG A  91
MET A 149
GLN A 153
LYS A 178
THR A 179
 GST  A 302 (-3.9A)
None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 ( 4.1A)
GST  A 302 (-3.7A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
 0.45A 4umjB-4llsA:
35.4		 4umjB-4llsA:
43.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_B_CHDB102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 LEU A 277
ARG A 278
LEU A  47
ALA A 207
LEU A 208
 None
 0.81A 4wg0B-4llsA:
undetectable
4wg0C-4llsA:
undetectable
4wg0D-4llsA:
undetectable		 4wg0B-4llsA:
4.65
4wg0C-4llsA:
4.65
4wg0D-4llsA:
4.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_D_CHDD102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 LEU A 277
ARG A 278
LEU A  47
ALA A 207
LEU A 208
 None
 0.84A 4wg0D-4llsA:
undetectable
4wg0E-4llsA:
undetectable
4wg0F-4llsA:
undetectable		 4wg0D-4llsA:
4.65
4wg0E-4llsA:
4.65
4wg0F-4llsA:
4.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_E_CHDE104_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 ALA A 207
LEU A 208
LEU A  47
LEU A 277
ARG A 278
 None
 0.81A 4wg0C-4llsA:
undetectable
4wg0D-4llsA:
undetectable
4wg0E-4llsA:
undetectable		 4wg0C-4llsA:
4.65
4wg0D-4llsA:
4.65
4wg0E-4llsA:
4.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_F_CHDF103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 LEU A 277
ARG A 278
LEU A  47
ALA A 207
LEU A 208
 None
 0.93A 4wg0F-4llsA:
undetectable
4wg0G-4llsA:
undetectable
4wg0H-4llsA:
undetectable		 4wg0F-4llsA:
4.65
4wg0G-4llsA:
4.65
4wg0H-4llsA:
4.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_G_CHDG103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 ALA A 207
LEU A 208
LEU A  47
LEU A 277
ARG A 278
 None
 0.81A 4wg0E-4llsA:
undetectable
4wg0F-4llsA:
undetectable
4wg0G-4llsA:
undetectable		 4wg0E-4llsA:
4.65
4wg0F-4llsA:
4.65
4wg0G-4llsA:
4.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_J_CHDJ103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 LEU A 277
ARG A 278
LEU A  47
ALA A 207
LEU A 208
 None
 0.94A 4wg0J-4llsA:
undetectable
4wg0K-4llsA:
undetectable
4wg0L-4llsA:
undetectable		 4wg0J-4llsA:
4.65
4wg0K-4llsA:
4.65
4wg0L-4llsA:
4.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_M_CHDM103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 ALA A 207
LEU A 208
LEU A  47
LEU A 277
ARG A 278
 None
 0.95A 4wg0K-4llsA:
undetectable
4wg0L-4llsA:
undetectable
4wg0M-4llsA:
undetectable		 4wg0K-4llsA:
4.65
4wg0L-4llsA:
4.65
4wg0M-4llsA:
4.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		4 / 6 SER A 167
LEU A 168
ASP A 169
LEU A 246
 None
 0.58A 4wozA-4llsA:
undetectable
4wozB-4llsA:
undetectable		 4wozA-4llsA:
21.97
4wozB-4llsA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_ACTA605_0
(SERUM ALBUMIN)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		4 / 6 HIS A  73
GLY A  40
GLU A  70
ARG A  42
 IPE  A 301 (-3.9A)
IPE  A 301 (-3.6A)
None
None
 1.29A 4zbqA-4llsA:
undetectable		 4zbqA-4llsA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 MET A 149
GLY A 177
GLN A 175
ARG A  44
GLY A 184
 GST  A 302 ( 4.1A)
None
None
IPE  A 301 (-3.1A)
None
 1.47A 5b1aA-4llsA:
2.2
5b1aB-4llsA:
undetectable
5b1aT-4llsA:
undetectable		 5b1aA-4llsA:
20.31
5b1aB-4llsA:
22.93
5b1aT-4llsA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 MET A 149
GLY A 177
GLN A 175
ARG A  44
GLY A 184
 GST  A 302 ( 4.1A)
None
None
IPE  A 301 (-3.1A)
None
 1.32A 5b1bA-4llsA:
2.0
5b1bB-4llsA:
undetectable
5b1bT-4llsA:
undetectable		 5b1bA-4llsA:
20.31
5b1bB-4llsA:
22.93
5b1bT-4llsA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_G_CHDG103_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 ARG A  44
GLY A 184
MET A 149
GLY A 148
GLN A 175
 IPE  A 301 (-3.1A)
None
GST  A 302 ( 4.1A)
None
None
 1.34A 5b1bG-4llsA:
undetectable
5b1bN-4llsA:
1.5
5b1bO-4llsA:
undetectable		 5b1bG-4llsA:
14.29
5b1bN-4llsA:
20.31
5b1bO-4llsA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_B_CHDB304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 MET A 149
GLY A 177
GLN A 175
ARG A  44
GLY A 184
 GST  A 302 ( 4.1A)
None
None
IPE  A 301 (-3.1A)
None
 1.48A 5b3sA-4llsA:
1.9
5b3sB-4llsA:
undetectable
5b3sT-4llsA:
undetectable		 5b3sA-4llsA:
20.31
5b3sB-4llsA:
22.93
5b3sT-4llsA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 12 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.69A 5cg5A-4llsA:
28.5		 5cg5A-4llsA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		9 / 12 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.67A 5cg5A-4llsA:
28.5		 5cg5A-4llsA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 12 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.71A 5cg6A-4llsA:
29.2		 5cg6A-4llsA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		9 / 12 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.68A 5cg6A-4llsA:
29.2		 5cg6A-4llsA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_A_210A804_1
(FUSICOCCADIENE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 9 LEU A  77
ARG A  91
LYS A 178
GLN A 213
LYS A 230
 None
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 ( 4.1A)
GST  A 302 (-2.7A)
 1.46A 5eroA-4llsA:
24.7		 5eroA-4llsA:
28.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_A_210A804_1
(FUSICOCCADIENE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		6 / 9 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
ASP A 216
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
CA  A 303 (-2.9A)
 0.72A 5eroA-4llsA:
24.7		 5eroA-4llsA:
28.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_A_210A804_1
(FUSICOCCADIENE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		6 / 9 LEU A  77
ASP A  86
ARG A  91
LYS A 178
GLN A 213
ASP A 216
 None
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
 0.84A 5eroA-4llsA:
24.7		 5eroA-4llsA:
28.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_B_210B804_1
(FUSICOCCADIENE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 9 ASP A  80
ASP A  86
ARG A  91
LYS A 178
ASP A 216
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
CA  A 303 (-2.9A)
 0.73A 5eroB-4llsA:
24.3		 5eroB-4llsA:
28.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_B_210B804_1
(FUSICOCCADIENE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 9 ASP A  86
ARG A  91
LYS A 178
GLN A 213
ASP A 216
 CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
 0.89A 5eroB-4llsA:
24.3		 5eroB-4llsA:
28.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_C_210C804_1
(FUSICOCCADIENE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 10 ASP A  80
ASP A  81
ASP A  86
ARG A  91
ASP A 235
 CA  A 304 ( 2.9A)
None
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
CA  A 303 ( 4.3A)
 1.07A 5eroC-4llsA:
24.5		 5eroC-4llsA:
28.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_C_210C804_1
(FUSICOCCADIENE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		6 / 10 ASP A  80
ASP A  81
ASP A  86
ARG A  91
LYS A 178
ASP A 216
 CA  A 304 ( 2.9A)
None
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
CA  A 303 (-2.9A)
 0.69A 5eroC-4llsA:
24.5		 5eroC-4llsA:
28.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_C_210C804_1
(FUSICOCCADIENE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		6 / 10 ASP A  81
ASP A  86
ARG A  91
LYS A 178
GLN A 213
ASP A 216
 None
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
 0.79A 5eroC-4llsA:
24.5		 5eroC-4llsA:
28.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_C_210C804_1
(FUSICOCCADIENE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 10 ASP A  86
ARG A  91
LYS A 178
GLN A 213
LYS A 230
 CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 ( 4.1A)
GST  A 302 (-2.7A)
 1.28A 5eroC-4llsA:
24.5		 5eroC-4llsA:
28.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		6 / 12 ALA A 263
GLU A 262
LEU A 210
ARG A 255
ILE A 183
GLY A 184
 None
 1.47A 5gtrA-4llsA:
undetectable		 5gtrA-4llsA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_2_PQN2843_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 12 ILE A  63
PHE A  24
ALA A  34
LEU A  21
ALA A  22
 None
 1.32A 5oy02-4llsA:
2.3		 5oy02-4llsA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_O_CHDO302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 ARG A  44
GLY A 184
MET A 149
GLY A 148
THR A 172
 IPE  A 301 (-3.1A)
None
GST  A 302 ( 4.1A)
None
None
 1.41A 5x1bG-4llsA:
undetectable
5x1bN-4llsA:
1.6
5x1bO-4llsA:
undetectable		 5x1bG-4llsA:
14.29
5x1bN-4llsA:
20.31
5x1bO-4llsA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_G_CHDG104_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 ARG A  44
GLY A 184
MET A 149
GLY A 177
GLN A 175
 IPE  A 301 (-3.1A)
None
GST  A 302 ( 4.1A)
None
None
 1.44A 5x1fG-4llsA:
undetectable
5x1fN-4llsA:
1.9
5x1fO-4llsA:
undetectable		 5x1fG-4llsA:
14.29
5x1fN-4llsA:
20.31
5x1fO-4llsA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_B_CHDB304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 MET A 149
GLY A 177
GLN A 175
ARG A  44
GLY A 184
 GST  A 302 ( 4.1A)
None
None
IPE  A 301 (-3.1A)
None
 1.45A 5xdqA-4llsA:
0.0
5xdqB-4llsA:
undetectable
5xdqT-4llsA:
undetectable		 5xdqA-4llsA:
20.31
5xdqB-4llsA:
22.93
5xdqT-4llsA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 MET A 149
GLY A 177
GLN A 175
ARG A  44
GLY A 184
 GST  A 302 ( 4.1A)
None
None
IPE  A 301 (-3.1A)
None
 1.43A 5xdxA-4llsA:
1.7
5xdxB-4llsA:
undetectable
5xdxT-4llsA:
undetectable		 5xdxA-4llsA:
20.31
5xdxB-4llsA:
22.93
5xdxT-4llsA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		3 / 3 ARG A  92
PHE A  17
ARG A  42
 IPE  A 301 (-3.8A)
None
None
 0.94A 5y9yA-4llsA:
undetectable		 5y9yA-4llsA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_B_CHDB301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 MET A 149
GLY A 177
GLN A 175
ARG A  44
GLY A 184
 GST  A 302 ( 4.1A)
None
None
IPE  A 301 (-3.1A)
None
 1.44A 5z84A-4llsA:
0.1
5z84B-4llsA:
undetectable
5z84T-4llsA:
undetectable		 5z84A-4llsA:
20.31
5z84B-4llsA:
22.93
5z84T-4llsA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 MET A 149
GLY A 177
GLN A 175
ARG A  44
GLY A 184
 GST  A 302 ( 4.1A)
None
None
IPE  A 301 (-3.1A)
None
 1.46A 5z86A-4llsA:
2.2
5z86B-4llsA:
undetectable
5z86T-4llsA:
undetectable		 5z86A-4llsA:
20.31
5z86B-4llsA:
22.93
5z86T-4llsA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 MET A 149
GLY A 177
GLN A 175
ARG A  44
GLY A 184
 GST  A 302 ( 4.1A)
None
None
IPE  A 301 (-3.1A)
None
 1.44A 5zcoA-4llsA:
2.0
5zcoB-4llsA:
undetectable
5zcoT-4llsA:
undetectable		 5zcoA-4llsA:
20.31
5zcoB-4llsA:
22.93
5zcoT-4llsA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_B_CHDB301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 MET A 149
GLY A 177
GLN A 175
ARG A  44
GLY A 184
 GST  A 302 ( 4.1A)
None
None
IPE  A 301 (-3.1A)
None
 1.46A 5zcpA-4llsA:
1.5
5zcpB-4llsA:
undetectable
5zcpT-4llsA:
undetectable		 5zcpA-4llsA:
20.31
5zcpB-4llsA:
22.93
5zcpT-4llsA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_B_CHDB301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 MET A 149
GLY A 177
GLN A 175
ARG A  44
GLY A 184
 GST  A 302 ( 4.1A)
None
None
IPE  A 301 (-3.1A)
None
 1.45A 5zcqA-4llsA:
0.6
5zcqB-4llsA:
undetectable
5zcqT-4llsA:
undetectable		 5zcqA-4llsA:
20.31
5zcqB-4llsA:
22.93
5zcqT-4llsA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_D95A816_0
(GEPHYRIN)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 ASP A 217
ILE A 218
LEU A 259
ARG A 287
ILE A 183
 None
None
None
IPE  A 301 ( 4.3A)
None
 1.40A 6fgcA-4llsA:
undetectable		 6fgcA-4llsA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_A_ZOLA401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		4 / 7 ASP A  80
ARG A  91
GLN A 153
LYS A 178
 CA  A 304 ( 2.9A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
GST  A 302 (-3.4A)
 0.95A 6g31A-4llsA:
23.7		 6g31A-4llsA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_A_ZOLA401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 7 ASP A  80
ASP A  86
ARG A  91
GLN A 153
GLN A 213
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
IPE  A 301 ( 4.1A)
 0.83A 6g31A-4llsA:
23.7		 6g31A-4llsA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_B_ZOLB401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 6 ASP A  80
ASP A  86
ARG A  91
GLN A 153
GLN A 213
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
IPE  A 301 ( 4.1A)
 0.91A 6g31B-4llsA:
23.8		 6g31B-4llsA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_C_ZOLC401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 5 ASP A  80
ASP A  86
ARG A  91
GLN A 153
LYS A 178
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
GST  A 302 (-3.4A)
 1.23A 6g31C-4llsA:
24.0		 6g31C-4llsA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_D_ZOLD401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 7 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
 0.52A 6g31D-4llsA:
23.1		 6g31D-4llsA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_D_ZOLD401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 7 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 213
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
IPE  A 301 ( 4.1A)
 0.76A 6g31D-4llsA:
23.1		 6g31D-4llsA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_E_ZOLE401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		4 / 4 LEU A  77
ASP A  80
ASP A  86
ARG A  91
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
 0.40A 6g31E-4llsA:
18.3		 6g31E-4llsA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_F_ZOLF401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		4 / 5 ASP A  80
ASP A  86
ARG A  91
GLN A 153
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
 0.57A 6g31F-4llsA:
24.0		 6g31F-4llsA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_F_ZOLF401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		4 / 5 ASP A  80
ASP A  86
ARG A  91
GLN A 213
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
IPE  A 301 ( 4.1A)
 0.88A 6g31F-4llsA:
24.0		 6g31F-4llsA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_G_ZOLG401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		4 / 7 ASP A  80
ASP A  86
ARG A  91
GLN A 153
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
 0.51A 6g31G-4llsA:
22.8		 6g31G-4llsA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_G_ZOLG401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		4 / 7 ASP A  80
ASP A  86
ARG A  91
GLN A 213
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
IPE  A 301 ( 4.1A)
 0.84A 6g31G-4llsA:
22.8		 6g31G-4llsA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_G_ZOLG401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		4 / 7 ASP A  80
ASP A  86
ARG A  91
LYS A 178
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
 0.82A 6g31G-4llsA:
22.8		 6g31G-4llsA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_J_ZOLJ401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 6 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
 0.68A 6g31J-4llsA:
23.8		 6g31J-4llsA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_J_ZOLJ401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 6 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 213
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
IPE  A 301 ( 4.1A)
 1.01A 6g31J-4llsA:
23.8		 6g31J-4llsA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_K_ZOLK401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		4 / 4 ASP A  80
ASP A  86
ARG A  91
GLN A 153
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
 0.60A 6g31K-4llsA:
22.2		 6g31K-4llsA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_L_ZOLL401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		4 / 6 ASP A  80
ASP A  86
ARG A  91
GLN A 153
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
 0.72A 6g31L-4llsA:
23.5		 6g31L-4llsA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_L_ZOLL401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		4 / 6 ASP A  80
ASP A  86
ARG A  91
GLN A 213
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
IPE  A 301 ( 4.1A)
 1.10A 6g31L-4llsA:
23.5		 6g31L-4llsA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_G_CHDG104_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 10 ARG A  44
GLY A 184
MET A 149
GLY A 148
THR A 172
 IPE  A 301 (-3.1A)
None
GST  A 302 ( 4.1A)
None
None
 1.49A 6nmfG-4llsA:
undetectable
6nmfN-4llsA:
0.7
6nmfO-4llsA:
undetectable		 6nmfG-4llsA:
14.29
6nmfN-4llsA:
20.31
6nmfO-4llsA:
22.93