SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4llu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LS4_H_TCIH220_2
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT
LIGHT CHAIN OF
ANTIBODY FAB
FRAGMENT)		 4llu LIGHT CHAIN CLAMBDA
(Homo
sapiens) 		4 / 5 TYR B  36
GLN B  89
ILE B  93
PHE B  98
 None
 1.27A 3ls4L-4lluB:
23.9		 3ls4L-4lluB:
49.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0U_A_ADNA501_1
(AURORA KINASE A)		 4llu LIGHT CHAIN CLAMBDA
(Homo
sapiens) 		5 / 6 VAL B 156
ALA B 151
LEU B 133
THR B 182
LEU B 181
 None
 1.49A 4o0uA-4lluB:
undetectable		 4o0uA-4lluB:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)		 4llu LIGHT CHAIN CLAMBDA
(Homo
sapiens) 		4 / 6 LEU B 133
ALA B 131
LEU B 179
THR B 182
 None
 1.06A 5bojA-4lluB:
3.9		 5bojA-4lluB:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		 4llu LIGHT CHAIN CLAMBDA
(Homo
sapiens) 		4 / 8 THR B  74
SER B  63
THR B  72
SER B  65
 None
 1.03A 5l4eA-4lluB:
undetectable
5l4eB-4lluB:
undetectable
5l4eC-4lluB:
undetectable
5l4eD-4lluB:
undetectable
5l4eE-4lluB:
undetectable		 5l4eA-4lluB:
20.32
5l4eB-4lluB:
20.32
5l4eC-4lluB:
20.32
5l4eD-4lluB:
20.32
5l4eE-4lluB:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		 4llu LIGHT CHAIN CLAMBDA
(Homo
sapiens) 		4 / 6 LEU B 133
ALA B 131
LEU B 179
THR B 182
 None
 1.02A 5l4iA-4lluB:
undetectable		 5l4iA-4lluB:
25.93