SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4llv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1H8S_A_AICA1000_1
(MUTANT AL2 6E7P9G)		 4llv 4E10 FV HEAVY CHAIN
4E10 FV LIGHT CHAIN
(Homo
sapiens) 		6 / 12 TYR B  36
GLN B  89
PHE B  98
VAL A  37
ALA A  93
TRP A 103
 None
 0.60A 1h8sA-4llvB:
21.6		 1h8sA-4llvB:
30.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_B_AG2B7011_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 4llv 4E10 FV HEAVY CHAIN
(Homo
sapiens) 		4 / 5 GLU A  46
ARG A  83
ASP A  86
LEU A  82
 None
 1.24A 1n13B-4llvA:
undetectable
1n13C-4llvA:
undetectable		 1n13B-4llvA:
23.66
1n13C-4llvA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		 4llv 4E10 FV HEAVY CHAIN
(Homo
sapiens) 		4 / 6 SER A  16
LEU A  82
SER A  17
GLU A  10
 None
 1.17A 2j2pE-4llvA:
undetectable
2j2pF-4llvA:
undetectable		 2j2pE-4llvA:
21.53
2j2pF-4llvA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		 4llv 4E10 FV LIGHT CHAIN
(Homo
sapiens) 		3 / 3 SER B  94
THR B  97
PHE B  71
 None
 0.54A 2x91A-4llvB:
undetectable		 2x91A-4llvB:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_A_MXDA551_1
(PROSTACYCLIN
SYNTHASE)		 4llv 4E10 FV HEAVY CHAIN
(Homo
sapiens) 		4 / 6 TYR A  32
ALA A  33
LEU A  34
ALA A  71
 None
 0.90A 3b6hA-4llvA:
undetectable		 3b6hA-4llvA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I9J_B_NCAB302_0
(ADP-RIBOSYL CYCLASE)		 4llv 4E10 FV HEAVY CHAIN
4E10 FV LIGHT CHAIN
(Homo
sapiens;
Homo
sapiens) 		4 / 6 LEU B  95
ASN A  58
TRP A  47
PHE B  98
 None
 1.41A 3i9jB-4llvB:
undetectable		 3i9jB-4llvB:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_B_KKKB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4llv 4E10 FV HEAVY CHAIN
4E10 FV LIGHT CHAIN
(Homo
sapiens) 		5 / 12 PHE B  71
PHE A 100
GLY A  50
ALA A  33
ILE A 100
 None
 1.48A 3ld6B-4llvB:
undetectable		 3ld6B-4llvB:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 4llv 4E10 FV HEAVY CHAIN
4E10 FV LIGHT CHAIN
(Homo
sapiens;
Homo
sapiens) 		5 / 12 ILE B  48
GLN B   6
TYR B  86
GLN A  39
LEU A  45
 None
 1.39A 4qztA-4llvB:
undetectable		 4qztA-4llvB:
21.28