SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lma'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_A_SAMA500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 4lma CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		5 / 11 GLU A 206
ALA A 204
PRO A 207
ALA A 276
ASP A 241
 None
 1.36A 2admA-4lmaA:
undetectable		 2admA-4lmaA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4lma CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		5 / 12 THR A 182
GLY A 183
GLY A 188
THR A 187
GLU A 191
 PLP  A 403 (-2.9A)
PLP  A 403 (-3.3A)
None
None
None
 1.36A 2akeA-4lmaA:
undetectable		 2akeA-4lmaA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4lma CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		5 / 12 THR A 182
GLY A 183
GLY A 188
THR A 187
GLU A 191
 PLP  A 403 (-2.9A)
PLP  A 403 (-3.3A)
None
None
None
 1.27A 2azxB-4lmaA:
undetectable		 2azxB-4lmaA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4lma CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		5 / 12 ALA A  81
SER A  44
ASN A  77
GLY A  50
ILE A  49
 None
PLP  A 403 ( 4.7A)
PLP  A 403 (-3.9A)
None
None
 1.09A 2dcfA-4lmaA:
undetectable		 2dcfA-4lmaA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4lma CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		5 / 11 ALA A  81
SER A  44
ASN A  77
GLY A  50
ILE A  49
 None
PLP  A 403 ( 4.7A)
PLP  A 403 (-3.9A)
None
None
 1.07A 2zmaA-4lmaA:
undetectable		 2zmaA-4lmaA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A65_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4lma CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		5 / 12 ALA A  81
SER A  44
ASN A  77
GLY A  50
ILE A  49
 None
PLP  A 403 ( 4.7A)
PLP  A 403 (-3.9A)
None
None
 1.11A 3a65A-4lmaA:
undetectable		 3a65A-4lmaA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A66_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4lma CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		5 / 10 ALA A  81
SER A  44
ASN A  77
GLY A  50
ILE A  49
 None
PLP  A 403 ( 4.7A)
PLP  A 403 (-3.9A)
None
None
 1.09A 3a66A-4lmaA:
undetectable		 3a66A-4lmaA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)		 4lma CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		5 / 12 ALA A 190
PRO A 154
GLY A 184
GLY A 183
ARG A 158
 None
None
PLP  A 403 (-3.8A)
PLP  A 403 (-3.3A)
None
 1.11A 3m6vA-4lmaA:
undetectable		 3m6vA-4lmaA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_2
(FIV PROTEASE)		 4lma CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		5 / 9 GLY A 113
ILE A  94
GLY A  79
ILE A  80
LEU A 116
 None
 0.99A 3ogpB-4lmaA:
undetectable		 3ogpB-4lmaA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA271_0
(PROTEIN SSM1)		 4lma CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		4 / 5 GLY A 227
GLU A 206
GLY A 229
PRO A 207
 None
 1.05A 3onnA-4lmaA:
2.9		 3onnA-4lmaA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWP_A_ACAA503_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4lma CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		5 / 10 ALA A  81
SER A  44
ASN A  77
GLY A  50
ILE A  49
 None
PLP  A 403 ( 4.7A)
PLP  A 403 (-3.9A)
None
None
 1.08A 3vwpA-4lmaA:
undetectable		 3vwpA-4lmaA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWQ_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4lma CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		5 / 12 ALA A  81
SER A  44
ASN A  77
GLY A  50
ILE A  49
 None
PLP  A 403 ( 4.7A)
PLP  A 403 (-3.9A)
None
None
 1.09A 3vwqA-4lmaA:
undetectable		 3vwqA-4lmaA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWR_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4lma CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		5 / 11 ALA A  81
SER A  44
ASN A  77
GLY A  50
ILE A  49
 None
PLP  A 403 ( 4.7A)
PLP  A 403 (-3.9A)
None
None
 1.08A 3vwrA-4lmaA:
undetectable		 3vwrA-4lmaA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_A_ADNA303_1
(5'/3'-NUCLEOTIDASE
SURE)		 4lma CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		5 / 10 TYR A  91
ALA A  57
LEU A  70
LEU A  82
TYR A 143
 None
 1.12A 4xj7A-4lmaA:
undetectable
4xj7B-4lmaA:
undetectable		 4xj7A-4lmaA:
22.57
4xj7B-4lmaA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGW_A_CTYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4lma CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		5 / 12 ILE A 226
GLY A 179
HIS A 221
ILE A 231
PHE A 230
 PLP  A 403 (-4.7A)
None
None
None
None
 1.16A 5igwA-4lmaA:
undetectable		 5igwA-4lmaA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND3_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 4lma CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		5 / 12 VAL A 205
GLU A 242
LEU A  19
ALA A 276
ARG A 283
 None
 1.09A 5nd3B-4lmaA:
undetectable		 5nd3B-4lmaA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFP_A_8W5A804_2
(GLUCOCORTICOID
RECEPTOR)		 4lma CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		4 / 4 LEU A  16
MET A  39
ILE A  32
LEU A 264
 None
 1.23A 5nfpA-4lmaA:
undetectable		 5nfpA-4lmaA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_1
(REGULATORY PROTEIN
TETR)		 4lma CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		4 / 8 GLN A 295
GLY A 271
ILE A 226
ASP A 248
 None
None
PLP  A 403 (-4.7A)
None
 0.94A 5vlmH-4lmaA:
undetectable		 5vlmH-4lmaA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_1
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 4lma CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		3 / 3 THR A  14
GLU A 164
HIS A 157
 None
None
PLP  A 403 ( 4.9A)
 0.93A 5xioA-4lmaA:
undetectable		 5xioA-4lmaA:
22.20