SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lmb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4003_1
(SERUM ALBUMIN)		 4lmb CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		5 / 9 ILE A 240
VAL A 180
GLY A 183
ALA A 204
LEU A 213
 None
PLP  A 403 (-3.9A)
PLP  A 403 (-3.4A)
None
None
 1.15A 1e7bA-4lmbA:
0.6		 1e7bA-4lmbA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		 4lmb CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		4 / 8 ARG A 105
SER A 102
SER A  75
LYS A  46
 PLP  A 403 ( 4.9A)
None
CYS  A 401 ( 2.6A)
PLP  A 403 ( 1.4A)
 1.02A 1hwiB-4lmbA:
undetectable		 1hwiB-4lmbA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_1
(HMG-COA REDUCTASE)		 4lmb CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		4 / 8 ARG A 105
SER A 102
SER A  75
LYS A  46
 PLP  A 403 ( 4.9A)
None
CYS  A 401 ( 2.6A)
PLP  A 403 ( 1.4A)
 1.01A 1hwkA-4lmbA:
undetectable		 1hwkA-4lmbA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_1
(HMG-COA REDUCTASE)		 4lmb CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		4 / 8 ARG A 105
SER A 102
SER A  75
LYS A  46
 PLP  A 403 ( 4.9A)
None
CYS  A 401 ( 2.6A)
PLP  A 403 ( 1.4A)
 1.04A 1hwkC-4lmbA:
undetectable		 1hwkC-4lmbA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_2
(HMG-COA REDUCTASE)		 4lmb CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		4 / 8 ARG A 105
SER A 102
SER A  75
LYS A  46
 PLP  A 403 ( 4.9A)
None
CYS  A 401 ( 2.6A)
PLP  A 403 ( 1.4A)
 1.05A 1hwkD-4lmbA:
undetectable		 1hwkD-4lmbA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_B_SAMB301_0
(HEMK PROTEIN)		 4lmb CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		5 / 12 THR A 161
ILE A 177
GLY A 178
ILE A 189
PRO A 296
 None
None
None
None
PLP  A 403 (-4.1A)
 0.95A 1nv8B-4lmbA:
3.2		 1nv8B-4lmbA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDU_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 4lmb CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		5 / 11 LEU A  19
ALA A 277
ILE A 175
ILE A 294
ILE A  32
 None
 1.02A 1sduA-4lmbA:
undetectable		 1sduA-4lmbA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)		 4lmb CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		5 / 12 THR A 161
ILE A 177
GLY A 178
ILE A 189
PRO A 296
 None
None
None
None
PLP  A 403 (-4.1A)
 1.03A 1sg9B-4lmbA:
3.1		 1sg9B-4lmbA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_B_SAMB301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 4lmb CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		5 / 12 THR A 161
ILE A 177
GLY A 178
ILE A 189
PRO A 296
 None
None
None
None
PLP  A 403 (-4.1A)
 1.03A 1vq1B-4lmbA:
3.1		 1vq1B-4lmbA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_A_SAMA500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 4lmb CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		5 / 11 GLU A 206
ALA A 204
PRO A 207
ALA A 276
ASP A 241
 None
 1.35A 2admA-4lmbA:
2.8		 2admA-4lmbA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4lmb CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		5 / 12 THR A 182
GLY A 183
GLY A 188
THR A 187
GLU A 191
 PLP  A 403 (-2.8A)
PLP  A 403 (-3.4A)
None
None
None
 1.32A 2akeA-4lmbA:
undetectable		 2akeA-4lmbA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4lmb CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		5 / 12 THR A 182
GLY A 183
GLY A 188
THR A 187
GLU A 191
 PLP  A 403 (-2.8A)
PLP  A 403 (-3.4A)
None
None
None
 1.30A 2azxA-4lmbA:
undetectable		 2azxA-4lmbA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4lmb CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		5 / 12 THR A 182
GLY A 183
GLY A 188
THR A 187
GLU A 191
 PLP  A 403 (-2.8A)
PLP  A 403 (-3.4A)
None
None
None
 1.23A 2azxB-4lmbA:
undetectable		 2azxB-4lmbA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4lmb CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		5 / 12 ALA A  81
SER A  44
ASN A  77
GLY A  50
ILE A  49
 None
None
PLP  A 403 ( 3.7A)
None
None
 1.13A 2dcfA-4lmbA:
undetectable		 2dcfA-4lmbA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_1
(CYTOCHROME P450 2C8)		 4lmb CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		5 / 12 THR A 161
THR A 169
VAL A 176
ALA A 202
VAL A 180
 None
None
None
None
PLP  A 403 (-3.9A)
 0.92A 2nniA-4lmbA:
undetectable		 2nniA-4lmbA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_1
(CYTOCHROME P450 2C8)		 4lmb CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		5 / 12 THR A 161
THR A 169
VAL A 176
ALA A 202
VAL A 205
 None
 1.20A 2nniA-4lmbA:
undetectable		 2nniA-4lmbA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 4lmb CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		5 / 12 TYR A 254
ALA A 273
GLY A 271
GLY A 267
ARG A 283
 None
 0.94A 2okcB-4lmbA:
2.1		 2okcB-4lmbA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 4lmb CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		5 / 12 LEU A  19
ALA A 277
ILE A 175
ILE A 294
ILE A  32
 None
 1.00A 2qakB-4lmbA:
undetectable		 2qakB-4lmbA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4lmb CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		5 / 11 ALA A  81
SER A  44
ASN A  77
GLY A  50
ILE A  49
 None
None
PLP  A 403 ( 3.7A)
None
None
 1.10A 2zmaA-4lmbA:
undetectable		 2zmaA-4lmbA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_0
(CATECHOL
O-METHYLTRANSFERASE)		 4lmb CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		5 / 12 VAL A  54
GLY A  79
TYR A  91
TYR A 112
SER A  75
 None
None
None
None
CYS  A 401 ( 2.6A)
 1.23A 2zthA-4lmbA:
3.5		 2zthA-4lmbA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A65_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4lmb CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		5 / 12 ALA A  81
SER A  44
ASN A  77
GLY A  50
ILE A  49
 None
None
PLP  A 403 ( 3.7A)
None
None
 1.15A 3a65A-4lmbA:
undetectable		 3a65A-4lmbA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A66_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4lmb CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		5 / 10 ALA A  81
SER A  44
ASN A  77
GLY A  50
ILE A  49
 None
None
PLP  A 403 ( 3.7A)
None
None
 1.13A 3a66A-4lmbA:
undetectable		 3a66A-4lmbA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXT_A_SAMA397_0
(PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1)		 4lmb CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		5 / 12 ARG A 301
LEU A 103
ALA A 107
ILE A  80
ARG A 105
 None
None
None
None
PLP  A 403 ( 4.9A)
 1.16A 3axtA-4lmbA:
3.4		 3axtA-4lmbA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4lmb CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		4 / 6 LEU A  93
ILE A  80
ALA A  81
THR A  74
 None
None
None
CYS  A 401 (-3.6A)
 1.09A 3mdrA-4lmbA:
undetectable		 3mdrA-4lmbA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A2000_1
(P38A)		 4lmb CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		5 / 12 ILE A 278
MET A 293
ARG A 197
ILE A  32
ALA A 273
 None
 1.07A 3ohtA-4lmbA:
undetectable
3ohtB-4lmbA:
undetectable		 3ohtA-4lmbA:
23.23
3ohtB-4lmbA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA271_0
(PROTEIN SSM1)		 4lmb CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		4 / 5 GLY A 227
GLU A 206
GLY A 229
PRO A 207
 CYS  A 402 ( 4.9A)
None
None
None
 1.08A 3onnA-4lmbA:
2.1		 3onnA-4lmbA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_B_RBFB190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 4lmb CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		5 / 12 LEU A 307
ASN A  77
ALA A 270
ALA A 272
LEU A 265
 None
PLP  A 403 ( 3.7A)
None
None
None
 1.16A 3p5nB-4lmbA:
1.6		 3p5nB-4lmbA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_B_ROCB801_2
(PROTEASE)		 4lmb CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		5 / 12 LEU A  19
ALA A 277
ILE A 175
ILE A 294
ILE A  32
 None
 1.00A 3tkgB-4lmbA:
undetectable		 3tkgB-4lmbA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWP_A_ACAA503_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4lmb CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		5 / 10 ALA A  81
SER A  44
ASN A  77
GLY A  50
ILE A  49
 None
None
PLP  A 403 ( 3.7A)
None
None
 1.12A 3vwpA-4lmbA:
undetectable		 3vwpA-4lmbA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWQ_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4lmb CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		5 / 12 ALA A  81
SER A  44
ASN A  77
GLY A  50
ILE A  49
 None
None
PLP  A 403 ( 3.7A)
None
None
 1.12A 3vwqA-4lmbA:
undetectable		 3vwqA-4lmbA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWR_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4lmb CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		5 / 11 ALA A  81
SER A  44
ASN A  77
GLY A  50
ILE A  49
 None
None
PLP  A 403 ( 3.7A)
None
None
 1.12A 3vwrA-4lmbA:
undetectable		 3vwrA-4lmbA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4lmb CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		4 / 6 ILE A 156
THR A 161
VAL A  54
ASP A   6
 None
 1.05A 4iaqA-4lmbA:
undetectable		 4iaqA-4lmbA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4lmb CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		4 / 7 THR A  78
ILE A  49
THR A 185
GLY A 183
 CYS  A 401 (-3.9A)
None
PLP  A 403 (-3.5A)
PLP  A 403 (-3.4A)
 0.88A 4l39B-4lmbA:
2.2		 4l39B-4lmbA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4lmb CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		5 / 12 ALA A 132
ILE A 240
GLY A 178
PHE A 230
THR A  74
 None
None
None
None
CYS  A 401 (-3.6A)
 1.13A 5jlcA-4lmbA:
undetectable		 5jlcA-4lmbA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MLM_A_STRA401_1
(-)		 4lmb CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		5 / 12 ILE A 226
MET A 101
ALA A 255
SER A 266
PRO A 296
 PLP  A 403 ( 4.7A)
CYS  A 402 (-4.5A)
None
None
PLP  A 403 (-4.1A)
 1.38A 5mlmA-4lmbA:
undetectable		 5mlmA-4lmbA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND3_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 4lmb CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		5 / 12 VAL A 205
GLU A 242
LEU A  19
ALA A 276
ARG A 283
 None
 1.06A 5nd3B-4lmbA:
undetectable		 5nd3B-4lmbA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND3_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 4lmb CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		5 / 12 VAL A 205
GLU A 242
LEU A 274
ALA A 276
ARG A 283
 None
 1.02A 5nd3B-4lmbA:
undetectable		 5nd3B-4lmbA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFP_A_8W5A804_2
(GLUCOCORTICOID
RECEPTOR)		 4lmb CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		4 / 4 LEU A  16
MET A  39
ILE A  32
LEU A 264
 None
 1.19A 5nfpA-4lmbA:
undetectable		 5nfpA-4lmbA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_C_SAMC301_0
(NS5)		 4lmb CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		5 / 12 GLY A 183
GLY A 229
GLY A 227
GLY A 181
GLU A 206
 PLP  A 403 (-3.4A)
None
CYS  A 402 ( 4.9A)
PLP  A 403 (-3.6A)
None
 0.92A 5njvC-4lmbA:
undetectable		 5njvC-4lmbA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4lmb CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		4 / 7 VAL A 180
ILE A 186
VAL A 243
ALA A 204
 PLP  A 403 (-3.9A)
None
None
None
 0.71A 5osrA-4lmbA:
undetectable		 5osrA-4lmbA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		 4lmb CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		4 / 6 ALA A  30
PRO A  23
VAL A  28
ASP A 288
 None
 1.16A 5umd2-4lmbA:
undetectable
5umdF-4lmbA:
undetectable		 5umd2-4lmbA:
10.56
5umdF-4lmbA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_A_SAMA301_0
(METHYLTRANSFERASE)		 4lmb CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		5 / 12 GLY A 183
GLY A 229
GLY A 227
GLY A 181
GLU A 206
 PLP  A 403 (-3.4A)
None
CYS  A 402 ( 4.9A)
PLP  A 403 (-3.6A)
None
 0.96A 5vimA-4lmbA:
undetectable		 5vimA-4lmbA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_1
(REGULATORY PROTEIN
TETR)		 4lmb CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		4 / 8 GLN A 295
GLY A 271
ILE A 226
ASP A 248
 None
None
PLP  A 403 ( 4.7A)
None
 0.94A 5vlmH-4lmbA:
undetectable		 5vlmH-4lmbA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_E_SAME601_0
(NS5
METHYLTRANSFERASE)		 4lmb CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		5 / 12 GLY A 188
GLY A 178
GLY A 184
GLU A  37
ILE A 177
 None
None
PLP  A 403 (-3.9A)
None
None
 1.04A 5wz1E-4lmbA:
undetectable		 5wz1E-4lmbA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_1
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 4lmb CYSTEINE SYNTHASE
(Microcystis
aeruginosa) 		3 / 3 THR A  14
GLU A 164
HIS A 157
 None
None
PLP  A 403 ( 4.9A)
 0.92A 5xioA-4lmbA:
2.3		 5xioA-4lmbA:
20.98