SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lmh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_A_DVAA6_0
(GRAMICIDIN A)
4lmh EXTRACELLULAR IRON
OXIDE RESPIRATORY
SYSTEM SURFACE
DECAHEME CYTOCHROME
C COMPONENT OMCA

(Shewanella
oneidensis)
3 / 3 ALA A 710
VAL A 712
TRP A 673
None
0.90A 1grmA-4lmhA:
undetectable
1grmA-4lmhA:
2.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_B_DVAB6_0
(GRAMICIDIN A)
4lmh EXTRACELLULAR IRON
OXIDE RESPIRATORY
SYSTEM SURFACE
DECAHEME CYTOCHROME
C COMPONENT OMCA

(Shewanella
oneidensis)
3 / 3 ALA A 710
VAL A 712
TRP A 673
None
0.90A 1grmB-4lmhA:
undetectable
1grmB-4lmhA:
2.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)
4lmh EXTRACELLULAR IRON
OXIDE RESPIRATORY
SYSTEM SURFACE
DECAHEME CYTOCHROME
C COMPONENT OMCA

(Shewanella
oneidensis)
4 / 7 ARG A  91
SER A 147
ASN A 149
ASP A  89
None
1.35A 1hwiC-4lmhA:
undetectable
1hwiC-4lmhA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)
4lmh EXTRACELLULAR IRON
OXIDE RESPIRATORY
SYSTEM SURFACE
DECAHEME CYTOCHROME
C COMPONENT OMCA

(Shewanella
oneidensis)
4 / 7 ARG A  91
SER A 147
ASN A 149
ASP A  89
None
1.35A 1hwiD-4lmhA:
undetectable
1hwiD-4lmhA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWE_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)
4lmh EXTRACELLULAR IRON
OXIDE RESPIRATORY
SYSTEM SURFACE
DECAHEME CYTOCHROME
C COMPONENT OMCA

(Shewanella
oneidensis)
4 / 7 VAL A 311
TYR A 296
TYR A 308
GLY A 280
HEC  A 801 ( 4.0A)
None
HEC  A 801 ( 4.6A)
None
0.95A 1lweA-4lmhA:
undetectable
1lweA-4lmhA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_A_DVAA6_0
(GRAMICIDIN A)
4lmh EXTRACELLULAR IRON
OXIDE RESPIRATORY
SYSTEM SURFACE
DECAHEME CYTOCHROME
C COMPONENT OMCA

(Shewanella
oneidensis)
3 / 3 ALA A 710
VAL A 712
TRP A 673
None
0.91A 1magA-4lmhA:
undetectable
1magA-4lmhA:
2.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_B_DVAB6_0
(GRAMICIDIN A)
4lmh EXTRACELLULAR IRON
OXIDE RESPIRATORY
SYSTEM SURFACE
DECAHEME CYTOCHROME
C COMPONENT OMCA

(Shewanella
oneidensis)
3 / 3 ALA A 710
VAL A 712
TRP A 673
None
0.91A 1magB-4lmhA:
undetectable
1magB-4lmhA:
2.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOA_A_3TCA302_1
(DEOXYCYTIDINE KINASE)
4lmh EXTRACELLULAR IRON
OXIDE RESPIRATORY
SYSTEM SURFACE
DECAHEME CYTOCHROME
C COMPONENT OMCA

(Shewanella
oneidensis)
5 / 12 ILE A 225
GLU A 248
PHE A 269
ALA A 251
ARG A 189
None
None
HEC  A 803 ( 3.9A)
HEC  A 803 ( 4.4A)
None
1.41A 2noaA-4lmhA:
undetectable
2noaA-4lmhA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA504_0
(CHORISMATE SYNTHASE)
4lmh EXTRACELLULAR IRON
OXIDE RESPIRATORY
SYSTEM SURFACE
DECAHEME CYTOCHROME
C COMPONENT OMCA

(Shewanella
oneidensis)
4 / 5 SER A 236
HIS A 232
LEU A 620
SER A 627
None
HEC  A 801 (-3.2A)
HEC  A 801 ( 3.9A)
HEC  A 801 (-2.6A)
1.45A 2qhfA-4lmhA:
undetectable
2qhfA-4lmhA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMJ_A_ACRA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)
4lmh EXTRACELLULAR IRON
OXIDE RESPIRATORY
SYSTEM SURFACE
DECAHEME CYTOCHROME
C COMPONENT OMCA

(Shewanella
oneidensis)
5 / 12 ASP A 450
ASN A 582
TRP A 660
ARG A 558
HIS A 639
None
None
None
HEC  A 808 (-4.2A)
HEC  A 808 (-3.1A)
1.38A 2qmjA-4lmhA:
undetectable
2qmjA-4lmhA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)
4lmh EXTRACELLULAR IRON
OXIDE RESPIRATORY
SYSTEM SURFACE
DECAHEME CYTOCHROME
C COMPONENT OMCA

(Shewanella
oneidensis)
5 / 12 SER A 402
VAL A 415
PHE A 465
ILE A 484
SER A 486
None
1.41A 2vdyA-4lmhA:
undetectable
2vdyA-4lmhA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGQ_A_PCFA1275_0
(WNT INHIBITORY
FACTOR 1)
4lmh EXTRACELLULAR IRON
OXIDE RESPIRATORY
SYSTEM SURFACE
DECAHEME CYTOCHROME
C COMPONENT OMCA

(Shewanella
oneidensis)
6 / 12 LEU A 411
ILE A 484
LEU A 467
PHE A 413
PHE A 543
VAL A 502
None
1.13A 2ygqA-4lmhA:
undetectable
2ygqA-4lmhA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)
4lmh EXTRACELLULAR IRON
OXIDE RESPIRATORY
SYSTEM SURFACE
DECAHEME CYTOCHROME
C COMPONENT OMCA

(Shewanella
oneidensis)
4 / 7 GLN A 142
GLY A 259
HIS A 240
CYH A 253
HEC  A 802 (-3.4A)
None
HEC  A 802 (-3.2A)
HEC  A 802 (-2.0A)
0.71A 3ai8A-4lmhA:
undetectable
3ai8A-4lmhA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_B_HNQB255_1
(CATHEPSIN B)
4lmh EXTRACELLULAR IRON
OXIDE RESPIRATORY
SYSTEM SURFACE
DECAHEME CYTOCHROME
C COMPONENT OMCA

(Shewanella
oneidensis)
4 / 6 GLN A 142
GLY A 259
HIS A 240
CYH A 253
HEC  A 802 (-3.4A)
None
HEC  A 802 (-3.2A)
HEC  A 802 (-2.0A)
0.77A 3ai8B-4lmhA:
undetectable
3ai8B-4lmhA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)
4lmh EXTRACELLULAR IRON
OXIDE RESPIRATORY
SYSTEM SURFACE
DECAHEME CYTOCHROME
C COMPONENT OMCA

(Shewanella
oneidensis)
3 / 3 GLY A 601
GLY A 663
GLY A 669
None
0.37A 3bogC-4lmhA:
undetectable
3bogC-4lmhA:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)
4lmh EXTRACELLULAR IRON
OXIDE RESPIRATORY
SYSTEM SURFACE
DECAHEME CYTOCHROME
C COMPONENT OMCA

(Shewanella
oneidensis)
3 / 3 GLY A 601
GLY A 663
GLY A 669
None
0.34A 3bogD-4lmhA:
undetectable
3bogD-4lmhA:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)
4lmh EXTRACELLULAR IRON
OXIDE RESPIRATORY
SYSTEM SURFACE
DECAHEME CYTOCHROME
C COMPONENT OMCA

(Shewanella
oneidensis)
4 / 5 ILE A 299
PRO A 129
LYS A 304
GLY A 303
None
None
HEC  A 802 ( 4.4A)
None
1.11A 3tkdB-4lmhA:
undetectable
3tkdB-4lmhA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)
4lmh EXTRACELLULAR IRON
OXIDE RESPIRATORY
SYSTEM SURFACE
DECAHEME CYTOCHROME
C COMPONENT OMCA

(Shewanella
oneidensis)
4 / 5 ILE A 299
PRO A 129
LYS A 304
GLY A 303
None
None
HEC  A 802 ( 4.4A)
None
1.09A 3tkdA-4lmhA:
undetectable
3tkdA-4lmhA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W9N_C_CCSC1548_0
(ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE)
4lmh EXTRACELLULAR IRON
OXIDE RESPIRATORY
SYSTEM SURFACE
DECAHEME CYTOCHROME
C COMPONENT OMCA

(Shewanella
oneidensis)
3 / 3 ALA A 659
TRP A 673
VAL A 674
None
0.33A 4w9nC-4lmhA:
undetectable
4w9nC-4lmhA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_1
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)
4lmh EXTRACELLULAR IRON
OXIDE RESPIRATORY
SYSTEM SURFACE
DECAHEME CYTOCHROME
C COMPONENT OMCA

(Shewanella
oneidensis)
3 / 3 SER A 263
GLU A 353
GLU A 102
None
0.75A 4ymgB-4lmhA:
undetectable
4ymgB-4lmhA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)
4lmh EXTRACELLULAR IRON
OXIDE RESPIRATORY
SYSTEM SURFACE
DECAHEME CYTOCHROME
C COMPONENT OMCA

(Shewanella
oneidensis)
5 / 12 ASP A 450
LEU A 682
ARG A 558
GLY A 653
LEU A 652
None
None
HEC  A 808 (-4.2A)
None
HEC  A 809 ( 4.8A)
1.21A 5m5cB-4lmhA:
undetectable
5m5cB-4lmhA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)
4lmh EXTRACELLULAR IRON
OXIDE RESPIRATORY
SYSTEM SURFACE
DECAHEME CYTOCHROME
C COMPONENT OMCA

(Shewanella
oneidensis)
5 / 10 ILE A 306
ILE A 299
LEU A 135
HIS A 277
ILE A 276
HEC  A 802 ( 4.4A)
None
None
HEC  A 801 ( 3.0A)
HEC  A 801 ( 4.3A)
1.38A 5vkqA-4lmhA:
undetectable
5vkqD-4lmhA:
undetectable
5vkqA-4lmhA:
18.57
5vkqD-4lmhA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)
4lmh EXTRACELLULAR IRON
OXIDE RESPIRATORY
SYSTEM SURFACE
DECAHEME CYTOCHROME
C COMPONENT OMCA

(Shewanella
oneidensis)
5 / 10 HIS A 277
ILE A 276
ILE A 306
ILE A 299
LEU A 135
HEC  A 801 ( 3.0A)
HEC  A 801 ( 4.3A)
HEC  A 802 ( 4.4A)
None
None
1.39A 5vkqA-4lmhA:
undetectable
5vkqB-4lmhA:
undetectable
5vkqA-4lmhA:
18.57
5vkqB-4lmhA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)
4lmh EXTRACELLULAR IRON
OXIDE RESPIRATORY
SYSTEM SURFACE
DECAHEME CYTOCHROME
C COMPONENT OMCA

(Shewanella
oneidensis)
5 / 10 HIS A 277
ILE A 276
ILE A 306
ILE A 299
LEU A 135
HEC  A 801 ( 3.0A)
HEC  A 801 ( 4.3A)
HEC  A 802 ( 4.4A)
None
None
1.37A 5vkqC-4lmhA:
undetectable
5vkqD-4lmhA:
undetectable
5vkqC-4lmhA:
18.57
5vkqD-4lmhA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA608_0
(ALPHA-AMYLASE)
4lmh EXTRACELLULAR IRON
OXIDE RESPIRATORY
SYSTEM SURFACE
DECAHEME CYTOCHROME
C COMPONENT OMCA

(Shewanella
oneidensis)
4 / 6 GLY A 592
THR A 606
TYR A 460
TYR A 454
None
HEC  A 807 (-3.4A)
HEC  A 807 (-3.9A)
None
1.29A 6ag0A-4lmhA:
undetectable
6ag0A-4lmhA:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC606_0
(ALPHA-AMYLASE)
4lmh EXTRACELLULAR IRON
OXIDE RESPIRATORY
SYSTEM SURFACE
DECAHEME CYTOCHROME
C COMPONENT OMCA

(Shewanella
oneidensis)
4 / 6 GLY A 592
THR A 606
TYR A 460
TYR A 454
None
HEC  A 807 (-3.4A)
HEC  A 807 (-3.9A)
None
1.27A 6ag0C-4lmhA:
undetectable
6ag0C-4lmhA:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA605_0
(SERUM ALBUMIN)
4lmh EXTRACELLULAR IRON
OXIDE RESPIRATORY
SYSTEM SURFACE
DECAHEME CYTOCHROME
C COMPONENT OMCA

(Shewanella
oneidensis)
4 / 8 HIS A 158
GLY A 159
LEU A  84
GLY A  83
None
0.82A 6mdqA-4lmhA:
undetectable
6mdqA-4lmhA:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)
4lmh EXTRACELLULAR IRON
OXIDE RESPIRATORY
SYSTEM SURFACE
DECAHEME CYTOCHROME
C COMPONENT OMCA

(Shewanella
oneidensis)
4 / 8 ARG A 243
HIS A 240
GLU A 195
ASP A  89
None
HEC  A 802 (-3.2A)
None
None
1.08A 6mn4B-4lmhA:
undetectable
6mn4B-4lmhA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)
4lmh EXTRACELLULAR IRON
OXIDE RESPIRATORY
SYSTEM SURFACE
DECAHEME CYTOCHROME
C COMPONENT OMCA

(Shewanella
oneidensis)
4 / 8 ARG A 243
HIS A 240
GLU A 195
ASP A  89
None
HEC  A 802 (-3.2A)
None
None
1.30A 6mn4C-4lmhA:
undetectable
6mn4C-4lmhA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_E_AM2E301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)
4lmh EXTRACELLULAR IRON
OXIDE RESPIRATORY
SYSTEM SURFACE
DECAHEME CYTOCHROME
C COMPONENT OMCA

(Shewanella
oneidensis)
4 / 7 ARG A 243
HIS A 240
GLU A 195
ASP A  89
None
HEC  A 802 (-3.2A)
None
None
1.32A 6mn4E-4lmhA:
undetectable
6mn4E-4lmhA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)
4lmh EXTRACELLULAR IRON
OXIDE RESPIRATORY
SYSTEM SURFACE
DECAHEME CYTOCHROME
C COMPONENT OMCA

(Shewanella
oneidensis)
4 / 7 ARG A 243
HIS A 240
GLU A 195
ASP A  89
None
HEC  A 802 (-3.2A)
None
None
1.38A 6mn4F-4lmhA:
undetectable
6mn4F-4lmhA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)
4lmh EXTRACELLULAR IRON
OXIDE RESPIRATORY
SYSTEM SURFACE
DECAHEME CYTOCHROME
C COMPONENT OMCA

(Shewanella
oneidensis)
3 / 3 ASP A 110
LEU A 342
ARG A 220
None
None
HEC  A 803 (-2.8A)
0.88A 7dfrA-4lmhA:
undetectable
7dfrA-4lmhA:
11.92