SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lmo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J7K_A_ACTA701_0
(HOLLIDAY JUNCTION
DNA HELICASE RUVB)		 4lmo TELOMERASE REVERSE
TRANSCRIPTASE
(Takifugu
rubripes) 		4 / 4 GLY A 302
LEU A 301
GLY A 306
ARG A 308
 None
 1.07A 1j7kA-4lmoA:
undetectable		 1j7kA-4lmoA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J7K_A_ACTA701_0
(HOLLIDAY JUNCTION
DNA HELICASE RUVB)		 4lmo TELOMERASE REVERSE
TRANSCRIPTASE
(Takifugu
rubripes) 		4 / 4 GLY A 302
LEU A 301
GLY A 307
ARG A 308
 None
 0.85A 1j7kA-4lmoA:
undetectable		 1j7kA-4lmoA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_E_REAE176_1
(RETINOL BINDING
PROTEIN)		 4lmo TELOMERASE REVERSE
TRANSCRIPTASE
(Takifugu
rubripes) 		5 / 10 LEU A 446
ALA A 509
VAL A 442
LEU A 420
PHE A 525
 None
 1.31A 1rlbE-4lmoA:
undetectable		 1rlbE-4lmoA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 4lmo TELOMERASE REVERSE
TRANSCRIPTASE
(Takifugu
rubripes) 		5 / 12 VAL A 337
ILE A 424
PHE A 502
HIS A 373
LEU A 315
 None
 1.24A 2ft9A-4lmoA:
undetectable		 2ft9A-4lmoA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4lmo TELOMERASE REVERSE
TRANSCRIPTASE
(Takifugu
rubripes) 		4 / 7 MET A 460
ARG A 487
GLY A 430
TRP A 429
 None
 1.12A 2pnjB-4lmoA:
undetectable		 2pnjB-4lmoA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_A_FOLA401_0
(DIHYDROFOLATE
REDUCTASE)		 4lmo TELOMERASE REVERSE
TRANSCRIPTASE
(Takifugu
rubripes) 		5 / 12 ILE A 334
LEU A 315
PHE A 366
ILE A 424
LEU A 428
 None
 1.08A 2w3bA-4lmoA:
undetectable		 2w3bA-4lmoA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_0
(DIHYDROFOLATE
REDUCTASE)		 4lmo TELOMERASE REVERSE
TRANSCRIPTASE
(Takifugu
rubripes) 		5 / 12 ILE A 334
LEU A 315
PHE A 366
ILE A 424
LEU A 428
 None
 1.10A 2w3bB-4lmoA:
undetectable		 2w3bB-4lmoA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_A_FOLA1188_0
(DIHYDROFOLATE
REDUCTASE)		 4lmo TELOMERASE REVERSE
TRANSCRIPTASE
(Takifugu
rubripes) 		5 / 12 ILE A 334
LEU A 315
PHE A 366
ILE A 424
LEU A 428
 None
 1.13A 2w3mA-4lmoA:
undetectable		 2w3mA-4lmoA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4lmo TELOMERASE REVERSE
TRANSCRIPTASE
(Takifugu
rubripes) 		5 / 11 VAL A 423
PHE A 494
TRP A 470
GLY A 330
ILE A 328
 None
 1.47A 3owxA-4lmoA:
undetectable
3owxB-4lmoA:
undetectable		 3owxA-4lmoA:
23.70
3owxB-4lmoA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KEB_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 4lmo TELOMERASE REVERSE
TRANSCRIPTASE
(Takifugu
rubripes) 		5 / 12 ILE A 334
LEU A 315
PHE A 366
ILE A 424
LEU A 428
 None
 1.13A 4kebB-4lmoA:
undetectable		 4kebB-4lmoA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4lmo TELOMERASE REVERSE
TRANSCRIPTASE
(Takifugu
rubripes) 		5 / 12 ILE A 334
LEU A 315
PHE A 366
ILE A 424
LEU A 428
 None
 1.10A 4m6kA-4lmoA:
undetectable		 4m6kA-4lmoA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_D_QI9D602_0
(CYTOCHROME P450 2D6)		 4lmo TELOMERASE REVERSE
TRANSCRIPTASE
(Takifugu
rubripes) 		4 / 7 PHE A 445
LEU A 446
VAL A 504
PHE A 502
 None
 1.05A 4wnvD-4lmoA:
undetectable		 4wnvD-4lmoA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_I_IPHI101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 4lmo TELOMERASE REVERSE
TRANSCRIPTASE
(Takifugu
rubripes) 		4 / 6 VAL A 423
HIS A 373
CYH A 419
LEU A 506
 None
 1.16A 5hrqB-4lmoA:
undetectable
5hrqI-4lmoA:
undetectable
5hrqJ-4lmoA:
undetectable		 5hrqB-4lmoA:
13.64
5hrqI-4lmoA:
7.27
5hrqJ-4lmoA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_K_IPHK101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 4lmo TELOMERASE REVERSE
TRANSCRIPTASE
(Takifugu
rubripes) 		4 / 6 VAL A 423
HIS A 373
CYH A 419
LEU A 506
 None
 1.23A 5hrqH-4lmoA:
undetectable
5hrqK-4lmoA:
undetectable
5hrqL-4lmoA:
undetectable		 5hrqH-4lmoA:
13.64
5hrqK-4lmoA:
7.27
5hrqL-4lmoA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4lmo TELOMERASE REVERSE
TRANSCRIPTASE
(Takifugu
rubripes) 		4 / 5 LEU A 370
PHE A 366
LEU A 315
PHE A 313
 None
 1.24A 5iy5P-4lmoA:
undetectable
5iy5W-4lmoA:
undetectable		 5iy5P-4lmoA:
20.22
5iy5W-4lmoA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 4lmo TELOMERASE REVERSE
TRANSCRIPTASE
(Takifugu
rubripes) 		4 / 5 LEU A 370
PHE A 366
LEU A 315
PHE A 313
 None
 1.27A 5xdxP-4lmoA:
undetectable
5xdxW-4lmoA:
undetectable		 5xdxP-4lmoA:
20.14
5xdxW-4lmoA:
12.50