SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lmp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB8_0
(ACTINOMYCIN D)		 4lmp ALANINE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		3 / 3 THR A 310
THR A 308
PRO A 306
 None
 0.75A 1a7yB-4lmpA:
undetectable		 1a7yB-4lmpA:
4.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA355_1
(PROTEIN (ADENOSINE
KINASE))		 4lmp ALANINE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  22
ILE A   5
ALA A  55
GLY A  54
ILE A  35
 None
 0.68A 1bx4A-4lmpA:
4.0		 1bx4A-4lmpA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_A_SAMA105_0
(PROTEIN (MET
REPRESSOR))		 4lmp ALANINE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 8 GLU A  25
ARG A  28
ARG A  29
LEU A 322
 None
 0.98A 1cmaA-4lmpA:
undetectable
1cmaB-4lmpA:
undetectable		 1cmaA-4lmpA:
13.54
1cmaB-4lmpA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FJA_C_DVAC8_0
(ACTINOMYCIN D)		 4lmp ALANINE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		3 / 3 THR A 310
THR A 308
PRO A 306
 None
 0.83A 1fjaC-4lmpA:
undetectable		 1fjaC-4lmpA:
4.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FJA_D_DVAD8_0
(ACTINOMYCIN D)		 4lmp ALANINE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		3 / 3 THR A 310
THR A 308
PRO A 306
 None
 0.83A 1fjaD-4lmpA:
undetectable		 1fjaD-4lmpA:
4.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE2_0
(ACTINOMYCIN D)		 4lmp ALANINE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		3 / 3 THR A 308
PRO A 306
THR A 310
 None
 0.77A 1i3wE-4lmpA:
undetectable		 1i3wE-4lmpA:
4.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG2_0
(ACTINOMYCIN D)		 4lmp ALANINE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		3 / 3 THR A 308
PRO A 306
THR A 310
 None
 0.79A 1i3wG-4lmpA:
undetectable		 1i3wG-4lmpA:
4.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OVF_B_DVAB2_0
(ACTINOMYCIN D)		 4lmp ALANINE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		3 / 3 THR A 308
PRO A 306
THR A 310
 None
 0.87A 1ovfB-4lmpA:
undetectable		 1ovfB-4lmpA:
4.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_B_DVAB8_0
(ACTINOMYCIN X2)		 4lmp ALANINE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		3 / 3 THR A 310
THR A 308
PRO A 306
 None
 0.72A 1qfiB-4lmpA:
undetectable		 1qfiB-4lmpA:
4.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_E_DVAE8_0
(7-AMINOACTINOMYCIN D)		 4lmp ALANINE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		3 / 3 THR A 310
THR A 308
PRO A 306
 None
 0.80A 1unmE-4lmpA:
undetectable		 1unmE-4lmpA:
4.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF2_0
(7-AMINOACTINOMYCIN D)		 4lmp ALANINE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		3 / 3 THR A 308
PRO A 306
THR A 310
 None
 0.87A 1unmF-4lmpA:
undetectable		 1unmF-4lmpA:
4.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF8_0
(7-AMINOACTINOMYCIN D)		 4lmp ALANINE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		3 / 3 THR A 310
THR A 308
PRO A 306
 None
 0.83A 1unmF-4lmpA:
undetectable		 1unmF-4lmpA:
4.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC2_0
(N8-ACTINOMYCIN D)		 4lmp ALANINE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		3 / 3 THR A 308
PRO A 306
THR A 310
 None
 0.62A 209dC-4lmpA:
undetectable		 209dC-4lmpA:
4.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC8_0
(N8-ACTINOMYCIN D)		 4lmp ALANINE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		3 / 3 THR A 310
THR A 308
PRO A 306
 None
 0.71A 209dC-4lmpA:
undetectable		 209dC-4lmpA:
4.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_A_SAMA501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 4lmp ALANINE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 8 CYH A 103
THR A  93
SER A 344
VAL A 355
 None
None
GOL  A 404 (-2.7A)
None
 0.95A 2fb2A-4lmpA:
undetectable		 2fb2A-4lmpA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_B_REAB1445_1
(PUTATIVE CYTOCHROME
P450 120)		 4lmp ALANINE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 THR A 314
ALA A  24
THR A  27
VAL A  33
GLY A   4
 None
 1.08A 2ve3B-4lmpA:
undetectable		 2ve3B-4lmpA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_B_SALB1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4lmp ALANINE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 10 ILE A  45
GLY A  40
THR A 310
PRO A  20
ILE A   5
 None
 1.32A 2y7wB-4lmpA:
undetectable		 2y7wB-4lmpA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_2
(HIV-1 PROTEASE)		 4lmp ALANINE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 9 LEU A 207
GLY A 189
ILE A 186
VAL A 196
ILE A 215
 None
 1.06A 3d1yB-4lmpA:
undetectable		 3d1yB-4lmpA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FW3_A_ETSA302_1
(CARBONIC ANHYDRASE 4)		 4lmp ALANINE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 HIS A 257
VAL A 235
ILE A 174
VAL A 172
LEU A 225
 None
 0.69A 3fw3A-4lmpA:
undetectable		 3fw3A-4lmpA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_A_4CHA191_0
(DEHALOPEROXIDASE A)		 4lmp ALANINE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 6 PHE A 211
HIS A 216
THR A 217
VAL A 196
 None
 0.96A 3lb3A-4lmpA:
undetectable		 3lb3A-4lmpA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 4lmp ALANINE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		6 / 12 ALA A 183
ALA A 137
ALA A 141
ALA A 176
GLY A 177
ALA A 238
 None
GOL  A 403 ( 3.8A)
None
None
GOL  A 402 (-3.5A)
None
 1.28A 3mg0Y-4lmpA:
undetectable
3mg0Z-4lmpA:
undetectable		 3mg0Y-4lmpA:
21.04
3mg0Z-4lmpA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_2
(PROTEASE)		 4lmp ALANINE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 10 LEU A 207
GLY A 189
ILE A 186
VAL A 196
ILE A 215
 None
 0.98A 3nu6B-4lmpA:
undetectable		 3nu6B-4lmpA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_B_FLPB701_1
(CYCLOOXYGENASE-2)		 4lmp ALANINE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 11 VAL A 196
LEU A 197
LEU A 207
GLY A 237
ALA A 238
 None
 1.14A 3pghB-4lmpA:
undetectable		 3pghB-4lmpA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_2
(PROTEASE)		 4lmp ALANINE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 10 GLY A  54
ALA A  55
ILE A   5
GLY A  22
ILE A  35
 None
 0.96A 3s43B-4lmpA:
undetectable		 3s43B-4lmpA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4lmp ALANINE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 180
GLY A 138
ILE A 267
ARG A 185
ALA A 184
 None
 1.22A 3uj7B-4lmpA:
5.3		 3uj7B-4lmpA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 4lmp ALANINE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 261
ALA A 262
GLY A 155
GLY A 157
VAL A 158
 None
 0.86A 4o33A-4lmpA:
5.0		 4o33A-4lmpA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 4lmp ALANINE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 261
ALA A 262
GLY A 155
GLY A 157
VAL A 158
 None
 0.83A 4o3fA-4lmpA:
4.8		 4o3fA-4lmpA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RS0_A_IBPA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4lmp ALANINE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 9 VAL A 196
LEU A 197
LEU A 207
GLY A 237
ALA A 238
 None
 1.12A 4rs0A-4lmpA:
undetectable		 4rs0A-4lmpA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVD_A_SAMA502_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 4lmp ALANINE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  45
GLY A  40
ALA A  37
VAL A  16
ILE A  18
 None
 1.02A 4rvdA-4lmpA:
6.3		 4rvdA-4lmpA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVG_A_SAMA503_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 4lmp ALANINE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  45
GLY A  40
ALA A  37
VAL A  16
ILE A  18
 None
 1.03A 4rvgA-4lmpA:
6.7		 4rvgA-4lmpA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4lmp ALANINE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		3 / 3 VAL A 265
ALA A 238
PHE A 275
 None
 0.82A 5js1A-4lmpA:
undetectable		 5js1A-4lmpA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_A_ADNA401_1
(ADENOSINE KINASE)		 4lmp ALANINE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  22
ILE A   5
ALA A  55
GLY A  54
ILE A  35
 None
 0.73A 5kb6A-4lmpA:
5.3		 5kb6A-4lmpA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_B_ADNB401_1
(ADENOSINE KINASE)		 4lmp ALANINE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  22
ILE A   5
ALA A  55
GLY A  54
ILE A  35
 None
 0.77A 5kb6B-4lmpA:
5.2		 5kb6B-4lmpA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_0
(METHYLTRANSFERASE)		 4lmp ALANINE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A  17
VAL A  16
GLY A  22
PHE A  50
ALA A  21
 None
 1.10A 5n5dA-4lmpA:
7.1		 5n5dA-4lmpA:
22.87