SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lmw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1P33_B_MTXB352_1 (PTERIDINE REDUCTASE 1)	4lmw	GLUTATHIONE TRANSFERASE (Phanerochaete chrysosporium)	5 / 12	SER A 209 PHE A 211 LEU A 177 LEU A 184 LEU A 193	None	1.48A	1p33B-4lmwA: undetectable	1p33B-4lmwA: 22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1YAT_A_FK5A108_1 (FK506 BINDING PROTEIN)	4lmw	GLUTATHIONE TRANSFERASE (Phanerochaete chrysosporium)	5 / 11	ARG A 104 PHE A 106 ILE A 91 LEU A 37 ILE A 6	None None None FMT A 308 ( 4.4A) FMT A 308 ( 4.7A)	1.13A	1yatA-4lmwA: undetectable	1yatA-4lmwA: 16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2BXM_A_IMNA2001_1 (SERUM ALBUMIN)	4lmw	GLUTATHIONE TRANSFERASE (Phanerochaete chrysosporium)	4 / 8	ALA A 116 PHE A 117 ALA A 121 LEU A 207	None	0.50A	2bxmA-4lmwA: 1.7	2bxmA-4lmwA: 16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2YA7_C_ZMRC1776_1 (NEURAMINIDASE A)	4lmw	GLUTATHIONE TRANSFERASE (Phanerochaete chrysosporium)	5 / 12	ILE A 11 ASP A 10 LEU A 126 ARG A 153 TYR A 46	None None None FMT A 305 ( 4.0A) FMT A 301 ( 4.9A)	1.11A	2ya7C-4lmwA: undetectable	2ya7C-4lmwA: 20.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4G19_A_ACTA304_0 (GLUTATHIONE TRANSFERASE GTE1)	4lmw	GLUTATHIONE TRANSFERASE (Phanerochaete chrysosporium)	4 / 5	ILE A 6 LEU A 37 LYS A 38 ASN A 80	FMT A 308 ( 4.7A) FMT A 308 ( 4.4A) FMT A 308 ( 4.1A) FMT A 308 ( 4.8A)	0.51A	4g19A-4lmwA: 38.6	4g19A-4lmwA: 59.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4G19_D_ACTD302_0 (GLUTATHIONE TRANSFERASE GTE1)	4lmw	GLUTATHIONE TRANSFERASE (Phanerochaete chrysosporium)	3 / 3	TYR A 46 PHE A 130 ARG A 153	FMT A 301 ( 4.9A) None FMT A 305 ( 4.0A)	0.89A	4g19D-4lmwA: 38.5	4g19D-4lmwA: 59.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4P6X_G_HCYG900_2 (GLUCOCORTICOID RECEPTOR)	4lmw	GLUTATHIONE TRANSFERASE (Phanerochaete chrysosporium)	3 / 3	LEU A 105 MET A 196 TYR A 118	None	0.84A	4p6xG-4lmwA: undetectable	4p6xG-4lmwA: 22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4P7N_A_GCSA702_1 (POLY-BETA-1,6-N-ACET YL-D-GLUCOSAMINE N-DEACETYLASE)	4lmw	GLUTATHIONE TRANSFERASE (Phanerochaete chrysosporium)	3 / 3	ASP A 250 TYR A 39 TRP A 43	None FMT A 306 (-4.5A) None	1.16A	4p7nA-4lmwA: undetectable	4p7nA-4lmwA: 23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5B8I_C_FK5C201_3 (PEPTIDYL-PROLYL CIS-TRANS ISOMERASE)	4lmw	GLUTATHIONE TRANSFERASE (Phanerochaete chrysosporium)	5 / 12	ARG A 104 PHE A 106 ILE A 91 LEU A 37 ILE A 6	None None None FMT A 308 ( 4.4A) FMT A 308 ( 4.7A)	1.12A	5b8iC-4lmwA: undetectable	5b8iC-4lmwA: 18.99

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1P33_B_MTXB352_1","PTERIDINE REDUCTASE 1","4lmw","GLUTATHIONE TRANSFERASE","Phanerochaete chrysosporium",5,"SER A 209;PHE A 211;LEU A 177;LEU A 184;LEU A 193","None","1.48A","1p33B-4lmwA:undetectable","1p33B-4lmwA:22.00"],["1YAT_A_FK5A108_1","FK506 BINDING PROTEIN","4lmw","GLUTATHIONE TRANSFERASE","Phanerochaete chrysosporium",5,"ARG A 104;PHE A 106;ILE A  91;LEU A  37;ILE A   6","None;None;None;FMT A 308 ( 4.4A);FMT A 308 ( 4.7A)","1.13A","1yatA-4lmwA:undetectable","1yatA-4lmwA:16.73"],["2BXM_A_IMNA2001_1","SERUM ALBUMIN","4lmw","GLUTATHIONE TRANSFERASE","Phanerochaete chrysosporium",4,"ALA A 116;PHE A 117;ALA A 121;LEU A 207","None","0.50A","2bxmA-4lmwA:1.7","2bxmA-4lmwA:16.72"],["2YA7_C_ZMRC1776_1","NEURAMINIDASE A","4lmw","GLUTATHIONE TRANSFERASE","Phanerochaete chrysosporium",5,"ILE A  11;ASP A  10;LEU A 126;ARG A 153;TYR A  46","None;None;None;FMT A 305 ( 4.0A);FMT A 301 ( 4.9A)","1.11A","2ya7C-4lmwA:undetectable","2ya7C-4lmwA:20.12"],["4G19_A_ACTA304_0","GLUTATHIONE TRANSFERASE GTE1","4lmw","GLUTATHIONE TRANSFERASE","Phanerochaete chrysosporium",4,"ILE A   6;LEU A  37;LYS A  38;ASN A  80","FMT A 308 ( 4.7A);FMT A 308 ( 4.4A);FMT A 308 ( 4.1A);FMT A 308 ( 4.8A)","0.51A","4g19A-4lmwA:38.6","4g19A-4lmwA:59.06"],["4G19_D_ACTD302_0","GLUTATHIONE TRANSFERASE GTE1","4lmw","GLUTATHIONE TRANSFERASE","Phanerochaete chrysosporium",3,"TYR A  46;PHE A 130;ARG A 153","FMT A 301 ( 4.9A);None;FMT A 305 ( 4.0A)","0.89A","4g19D-4lmwA:38.5","4g19D-4lmwA:59.06"],["4P6X_G_HCYG900_2","GLUCOCORTICOID RECEPTOR","4lmw","GLUTATHIONE TRANSFERASE","Phanerochaete chrysosporium",3,"LEU A 105;MET A 196;TYR A 118","None","0.84A","4p6xG-4lmwA:undetectable","4p6xG-4lmwA:22.99"],["4P7N_A_GCSA702_1","POLY-BETA-1,6-N-ACETYL-D-GLUCOSAMINE N-DEACETYLASE","4lmw","GLUTATHIONE TRANSFERASE","Phanerochaete chrysosporium",3,"ASP A 250;TYR A  39;TRP A  43","None;FMT A 306 (-4.5A);None","1.16A","4p7nA-4lmwA:undetectable","4p7nA-4lmwA:23.08"],["5B8I_C_FK5C201_3","PEPTIDYL-PROLYL CIS-TRANS ISOMERASE","4lmw","GLUTATHIONE TRANSFERASE","Phanerochaete chrysosporium",5,"ARG A 104;PHE A 106;ILE A  91;LEU A  37;ILE A   6","None;None;None;FMT A 308 ( 4.4A);FMT A 308 ( 4.7A)","1.12A","5b8iC-4lmwA:undetectable","5b8iC-4lmwA:18.99"]]