SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lmx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4lmx CRYPTOPHYTE
PHYCOERYTHRIN (BETA
CHAIN)
(Hemiselmis
andersenii) 		3 / 3 SER B  46
ASP B  39
CYH B 158
 None
PEB  B 202 (-3.3A)
PEB  B 202 (-1.8A)
 0.86A 2br4E-4lmxB:
undetectable		 2br4E-4lmxB:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_F_CSCF1383_2
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 4lmx CRYPTOPHYTE
PHYCOERYTHRIN (BETA
CHAIN)
(Hemiselmis
andersenii) 		3 / 3 LEU B  98
MET B  38
MET B 134
 None
PEB  B 202 (-4.7A)
None
 1.06A 2vavF-4lmxB:
undetectable		 2vavF-4lmxB:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG305_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4lmx CRYPTOPHYTE
PHYCOERYTHRIN
(ALPHA-2 CHAIN)
CRYPTOPHYTE
PHYCOERYTHRIN (BETA
CHAIN)
(Hemiselmis
andersenii;
Hemiselmis
andersenii) 		3 / 3 ASP A   5
ARG B 108
LYS A   3
 LYZ  A   4 (-4.6A)
None
None
 0.98A 3wipG-4lmxA:
undetectable		 3wipG-4lmxA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4lmx CRYPTOPHYTE
PHYCOERYTHRIN
(ALPHA-2 CHAIN)
CRYPTOPHYTE
PHYCOERYTHRIN (BETA
CHAIN)
(Hemiselmis
andersenii;
Hemiselmis
andersenii) 		5 / 10 VAL A  38
ALA B  16
SER B   6
LEU B  27
VAL A  36
 None
 1.36A 4eilB-4lmxA:
undetectable		 4eilB-4lmxA:
7.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4lmx CRYPTOPHYTE
PHYCOERYTHRIN
(ALPHA-2 CHAIN)
CRYPTOPHYTE
PHYCOERYTHRIN (BETA
CHAIN)
(Hemiselmis
andersenii;
Hemiselmis
andersenii) 		5 / 11 VAL A  38
ALA B  16
SER B   6
LEU B  27
VAL A  36
 None
 1.46A 4eilE-4lmxA:
undetectable		 4eilE-4lmxA:
7.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4lmx CRYPTOPHYTE
PHYCOERYTHRIN
(ALPHA-2 CHAIN)
CRYPTOPHYTE
PHYCOERYTHRIN (BETA
CHAIN)
(Hemiselmis
andersenii;
Hemiselmis
andersenii) 		5 / 10 VAL A  38
ALA B  16
SER B   6
LEU B  27
VAL A  36
 None
 1.47A 4kyaC-4lmxA:
undetectable		 4kyaC-4lmxA:
7.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4lmx CRYPTOPHYTE
PHYCOERYTHRIN
(ALPHA-2 CHAIN)
CRYPTOPHYTE
PHYCOERYTHRIN (BETA
CHAIN)
(Hemiselmis
andersenii;
Hemiselmis
andersenii) 		5 / 12 VAL A  38
ALA B  16
SER B   6
LEU B  27
VAL A  36
 None
 1.40A 4kyaD-4lmxA:
undetectable		 4kyaD-4lmxA:
7.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4lmx CRYPTOPHYTE
PHYCOERYTHRIN
(ALPHA-2 CHAIN)
CRYPTOPHYTE
PHYCOERYTHRIN (BETA
CHAIN)
(Hemiselmis
andersenii;
Hemiselmis
andersenii) 		5 / 12 VAL A  38
ALA B  16
SER B   6
LEU B  27
VAL A  36
 None
 1.40A 4kyaF-4lmxA:
undetectable		 4kyaF-4lmxA:
7.82