SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ln1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB6_0
(GRAMICIDIN A)		 4ln1 L-LACTATE
DEHYDROGENASE 1
(Bacillus
cereus) 		3 / 3 TRP A 133
ALA A 259
VAL A 143
 None
 0.80A 1c4dA-4ln1A:
undetectable
1c4dB-4ln1A:
undetectable		 1c4dA-4ln1A:
6.78
1c4dB-4ln1A:
6.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))		 4ln1 L-LACTATE
DEHYDROGENASE 1
(Bacillus
cereus) 		6 / 9 VAL A  11
GLY A  12
ASP A  37
TYR A  68
ALA A  81
ILE A 101
 None
 0.74A 1cetA-4ln1A:
41.6		 1cetA-4ln1A:
30.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_C_9CRC502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ln1 L-LACTATE
DEHYDROGENASE 1
(Bacillus
cereus) 		5 / 10 ALA A 259
LEU A 278
SER A 253
LEU A 287
ILE A 286
 None
 1.22A 1g5yC-4ln1A:
undetectable		 1g5yC-4ln1A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4ln1 L-LACTATE
DEHYDROGENASE 1
(Bacillus
cereus) 		5 / 9 VAL A  16
GLY A 237
ALA A 121
THR A 149
ILE A 236
 None
 1.27A 1gtnL-4ln1A:
undetectable
1gtnM-4ln1A:
undetectable		 1gtnL-4ln1A:
14.59
1gtnM-4ln1A:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_0
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 4ln1 L-LACTATE
DEHYDROGENASE 1
(Bacillus
cereus) 		5 / 12 THR A 129
ASN A  98
GLY A  12
THR A 122
ALA A 121
 None
 1.12A 1jg4A-4ln1A:
4.1		 1jg4A-4ln1A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 4ln1 L-LACTATE
DEHYDROGENASE 1
(Bacillus
cereus) 		5 / 11 ALA A 172
LEU A 200
LEU A 211
LEU A 159
LEU A 196
 None
 1.09A 2ceoA-4ln1A:
undetectable		 2ceoA-4ln1A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		 4ln1 L-LACTATE
DEHYDROGENASE 1
(Bacillus
cereus) 		4 / 7 SER A 152
ASP A 151
VAL A 185
LEU A 261
 None
 0.97A 2hdnE-4ln1A:
undetectable
2hdnF-4ln1A:
2.8
2hdnH-4ln1A:
2.5		 2hdnE-4ln1A:
8.17
2hdnF-4ln1A:
23.66
2hdnH-4ln1A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		 4ln1 L-LACTATE
DEHYDROGENASE 1
(Bacillus
cereus) 		4 / 7 VAL A 185
LEU A 261
SER A 152
ASP A 151
 None
 0.92A 2hdnF-4ln1A:
2.8
2hdnG-4ln1A:
undetectable
2hdnH-4ln1A:
2.7		 2hdnF-4ln1A:
23.66
2hdnG-4ln1A:
8.17
2hdnH-4ln1A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNJ_A_225A501_1
(CYTOCHROME P450 2C8)		 4ln1 L-LACTATE
DEHYDROGENASE 1
(Bacillus
cereus) 		5 / 10 ILE A 170
LEU A 211
VAL A 189
ALA A 172
VAL A 218
 None
 1.04A 2nnjA-4ln1A:
undetectable		 2nnjA-4ln1A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RIW_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 4ln1 L-LACTATE
DEHYDROGENASE 1
(Bacillus
cereus) 		5 / 10 ALA A 172
LEU A 200
LEU A 211
LEU A 159
LEU A 196
 None
 1.15A 2riwA-4ln1A:
undetectable
2riwB-4ln1A:
undetectable		 2riwA-4ln1A:
23.74
2riwB-4ln1A:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN6_A_T44A1370_1
(THYROXINE-BINDING
GLOBULIN)		 4ln1 L-LACTATE
DEHYDROGENASE 1
(Bacillus
cereus) 		5 / 10 ALA A 172
LEU A 200
LEU A 211
LEU A 159
LEU A 196
 None
 1.05A 2xn6A-4ln1A:
undetectable
2xn6B-4ln1A:
undetectable		 2xn6A-4ln1A:
23.23
2xn6B-4ln1A:
7.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN7_A_T44A1355_1
(THYROXINE-BINDING
GLOBULIN)		 4ln1 L-LACTATE
DEHYDROGENASE 1
(Bacillus
cereus) 		5 / 10 ALA A 172
LEU A 200
LEU A 211
LEU A 159
LEU A 196
 None
 1.02A 2xn7A-4ln1A:
undetectable
2xn7B-4ln1A:
undetectable		 2xn7A-4ln1A:
23.23
2xn7B-4ln1A:
7.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_A_SALA305_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 4ln1 L-LACTATE
DEHYDROGENASE 1
(Bacillus
cereus) 		4 / 7 VAL A 243
THR A 244
ILE A 247
ILE A 117
 None
 0.87A 3deuA-4ln1A:
undetectable		 3deuA-4ln1A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 4ln1 L-LACTATE
DEHYDROGENASE 1
(Bacillus
cereus) 		5 / 10 LEU A 183
SER A 302
ILE A 175
SER A 258
GLY A 273
 None
 1.28A 3ijxB-4ln1A:
undetectable
3ijxD-4ln1A:
undetectable		 3ijxB-4ln1A:
23.84
3ijxD-4ln1A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB262_1
(GLUTAMATE RECEPTOR 2)		 4ln1 L-LACTATE
DEHYDROGENASE 1
(Bacillus
cereus) 		5 / 10 ILE A 175
SER A 258
GLY A 273
LEU A 183
SER A 302
 None
 1.20A 3ik6B-4ln1A:
undetectable
3ik6E-4ln1A:
undetectable		 3ik6B-4ln1A:
23.84
3ik6E-4ln1A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 4ln1 L-LACTATE
DEHYDROGENASE 1
(Bacillus
cereus) 		5 / 10 LEU A 183
SER A 302
ILE A 175
SER A 258
GLY A 273
 None
 1.24A 3ik6B-4ln1A:
undetectable
3ik6E-4ln1A:
undetectable		 3ik6B-4ln1A:
23.84
3ik6E-4ln1A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		 4ln1 L-LACTATE
DEHYDROGENASE 1
(Bacillus
cereus) 		5 / 10 LEU A 183
SER A 302
ILE A 175
SER A 258
GLY A 273
 None
 1.25A 3iluB-4ln1A:
undetectable
3iluE-4ln1A:
undetectable		 3iluB-4ln1A:
23.84
3iluE-4ln1A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		 4ln1 L-LACTATE
DEHYDROGENASE 1
(Bacillus
cereus) 		5 / 11 ILE A 175
SER A 258
GLY A 273
LEU A 183
SER A 302
 None
 1.23A 3iluB-4ln1A:
undetectable
3iluE-4ln1A:
undetectable		 3iluB-4ln1A:
23.84
3iluE-4ln1A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_F_TFPF202_1
(PROTEIN S100-A4)		 4ln1 L-LACTATE
DEHYDROGENASE 1
(Bacillus
cereus) 		5 / 11 GLU A 295
LEU A 291
PHE A 299
ILE A 175
ASP A 212
 None
 1.37A 3ko0E-4ln1A:
undetectable
3ko0F-4ln1A:
undetectable
3ko0G-4ln1A:
undetectable
3ko0H-4ln1A:
undetectable		 3ko0E-4ln1A:
17.23
3ko0F-4ln1A:
17.23
3ko0G-4ln1A:
17.23
3ko0H-4ln1A:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SM2_A_478A126_2
(GAG-PRO-POL
POLYPROTEIN)		 4ln1 L-LACTATE
DEHYDROGENASE 1
(Bacillus
cereus) 		5 / 11 ALA A 121
VAL A  78
GLY A 237
LEU A  10
LEU A 119
 None
 0.99A 3sm2B-4ln1A:
undetectable		 3sm2B-4ln1A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_2
(BLUE-LIGHT
PHOTORECEPTOR)		 4ln1 L-LACTATE
DEHYDROGENASE 1
(Bacillus
cereus) 		5 / 9 VAL A 243
ILE A 247
LEU A 248
ILE A 144
GLY A 116
 None
 1.11A 4kukA-4ln1A:
undetectable		 4kukA-4ln1A:
18.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OKN_B_KANB403_1
(L-LACTATE
DEHYDROGENASE A
CHAIN)		 4ln1 L-LACTATE
DEHYDROGENASE 1
(Bacillus
cereus) 		6 / 9 ASP A  37
VAL A  38
TYR A  68
ALA A  81
ILE A 101
ILE A 105
 None
 0.68A 4oknB-4ln1A:
41.5		 4oknB-4ln1A:
38.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MLM_A_STRA401_1
(-)		 4ln1 L-LACTATE
DEHYDROGENASE 1
(Bacillus
cereus) 		5 / 12 PHE A 114
ALA A 121
SER A 146
VAL A  78
ILE A  79
 None
 1.47A 5mlmA-4ln1A:
10.1		 5mlmA-4ln1A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_B_HISB402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 4ln1 L-LACTATE
DEHYDROGENASE 1
(Bacillus
cereus) 		5 / 9 VAL A  77
GLY A 137
LEU A 138
THR A 132
VAL A 106
 None
 1.20A 6czmA-4ln1A:
undetectable
6czmB-4ln1A:
undetectable		 6czmA-4ln1A:
23.10
6czmB-4ln1A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_BEZA401_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4ln1 L-LACTATE
DEHYDROGENASE 1
(Bacillus
cereus) 		5 / 9 SER A 136
THR A 132
ILE A  79
VAL A  11
ILE A 109
 None
 1.12A 6ef6A-4ln1A:
undetectable		 6ef6A-4ln1A:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLP_A_GAWA1501_0
(SUBSTANCE-P
RECEPTOR,SUBSTANCE-P
RECEPTOR)		 4ln1 L-LACTATE
DEHYDROGENASE 1
(Bacillus
cereus) 		5 / 12 ILE A 144
ILE A 117
VAL A 243
THR A 244
ILE A 247
 None
 0.95A 6hlpA-4ln1A:
7.8		 6hlpA-4ln1A:
20.87