SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ln9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_0
(MODIFICATION
METHYLASE RSRI)		 4ln9 RIFAMYCIN POLYKETIDE
SYNTHASE
(Amycolatopsis
mediterranei) 		5 / 12 GLY A  22
SER A  37
VAL A  98
ALA A  14
ALA A   8
 None
 1.22A 1nw5A-4ln9A:
undetectable		 1nw5A-4ln9A:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4ln9 RIFAMYCIN POLYKETIDE
SYNTHASE
(Amycolatopsis
mediterranei) 		4 / 4 ALA A 221
VAL A 181
ALA A 180
HIS A 215
 None
 1.04A 1q23A-4ln9A:
undetectable		 1q23A-4ln9A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_F_REAF177_1
(RETINOL BINDING
PROTEIN)		 4ln9 RIFAMYCIN POLYKETIDE
SYNTHASE
(Amycolatopsis
mediterranei) 		5 / 11 LEU A  88
ALA A 101
VAL A  58
LEU A  47
LEU A  20
 None
 0.99A 1rlbF-4ln9A:
undetectable		 1rlbF-4ln9A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_3
(PROTEASE)		 4ln9 RIFAMYCIN POLYKETIDE
SYNTHASE
(Amycolatopsis
mediterranei) 		5 / 12 ASP A  54
GLY A 175
PRO A  59
VAL A  58
VAL A  56
 None
 0.95A 2nnkB-4ln9A:
undetectable		 2nnkB-4ln9A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4ln9 RIFAMYCIN POLYKETIDE
SYNTHASE
(Amycolatopsis
mediterranei) 		4 / 5 LEU A  47
ILE A  57
GLY A  62
HIS A 215
 None
 1.01A 2otfA-4ln9A:
undetectable		 2otfA-4ln9A:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 4ln9 RIFAMYCIN POLYKETIDE
SYNTHASE
(Amycolatopsis
mediterranei) 		5 / 12 LEU A 260
PHE A 212
THR A  61
LEU A 250
VAL A 285
 None
 1.29A 3sp9A-4ln9A:
undetectable		 3sp9A-4ln9A:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_B_IL2B901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 4ln9 RIFAMYCIN POLYKETIDE
SYNTHASE
(Amycolatopsis
mediterranei) 		5 / 12 LEU A 260
PHE A 212
THR A  61
LEU A 250
VAL A 285
 None
 1.28A 3sp9B-4ln9A:
undetectable		 3sp9B-4ln9A:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4ln9 RIFAMYCIN POLYKETIDE
SYNTHASE
(Amycolatopsis
mediterranei) 		4 / 8 LEU A 219
VAL A 262
VAL A 284
LEU A 223
 None
 0.95A 3v81C-4ln9A:
undetectable		 3v81C-4ln9A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 4ln9 RIFAMYCIN POLYKETIDE
SYNTHASE
(Amycolatopsis
mediterranei) 		4 / 8 LEU A 219
VAL A 262
VAL A 284
LEU A 223
 None
 1.03A 4pwdC-4ln9A:
undetectable		 4pwdC-4ln9A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0B_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 4ln9 RIFAMYCIN POLYKETIDE
SYNTHASE
(Amycolatopsis
mediterranei) 		4 / 8 LEU A 219
VAL A 262
VAL A 284
LEU A 223
 None
 0.90A 4q0bA-4ln9A:
undetectable		 4q0bA-4ln9A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_A_BQ1A1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 4ln9 RIFAMYCIN POLYKETIDE
SYNTHASE
(Amycolatopsis
mediterranei) 		3 / 3 GLU A 208
ALA A 209
PHE A 212
 None
 0.59A 4v1fA-4ln9A:
undetectable		 4v1fA-4ln9A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_C_BQ1C1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 4ln9 RIFAMYCIN POLYKETIDE
SYNTHASE
(Amycolatopsis
mediterranei) 		3 / 3 GLU A 208
ALA A 209
PHE A 212
 None
 0.65A 4v1fC-4ln9A:
undetectable		 4v1fC-4ln9A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_2
(PROTEIN CYP51)		 4ln9 RIFAMYCIN POLYKETIDE
SYNTHASE
(Amycolatopsis
mediterranei) 		4 / 6 PRO A 244
LEU A 243
PHE A 245
LEU A 290
 None
 1.16A 5tl8A-4ln9A:
undetectable		 5tl8A-4ln9A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4ln9 RIFAMYCIN POLYKETIDE
SYNTHASE
(Amycolatopsis
mediterranei) 		5 / 9 PRO A  91
GLY A  95
SER A  43
LEU A  88
LEU A  20
 None
 1.49A 6dm0A-4ln9A:
undetectable
6dm0D-4ln9A:
undetectable		 6dm0A-4ln9A:
12.31
6dm0D-4ln9A:
12.31