SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lna'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3001_1
(SERUM ALBUMIN)		 4lna PURINE NUCLEOSIDE
PHOSPHORYLASE
(Spirosoma
linguale) 		5 / 11 TYR A 159
PRO A 139
LEU A 140
HIS A 130
ALA A 219
 None
 1.39A 1hk3A-4lnaA:
undetectable		 1hk3A-4lnaA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_E_ADNE4260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 4lna PURINE NUCLEOSIDE
PHOSPHORYLASE
(Spirosoma
linguale) 		5 / 12 GLY A 113
GLU A 192
VAL A 208
MET A 210
ASP A 234
 ADE  A 502 (-3.6A)
ADE  A 502 (-2.9A)
ADE  A 502 (-4.5A)
MPD  A 503 ( 3.2A)
ADE  A 502 (-2.9A)
 0.61A 1jdvE-4lnaA:
22.3
1jdvF-4lnaA:
21.8		 1jdvE-4lnaA:
21.61
1jdvF-4lnaA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		 4lna PURINE NUCLEOSIDE
PHOSPHORYLASE
(Spirosoma
linguale) 		5 / 12 ILE A 232
ALA A 207
PHE A 119
ASN A 110
LEU A 260
 None
 1.02A 1og5B-4lnaA:
undetectable		 1og5B-4lnaA:
20.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4lna PURINE NUCLEOSIDE
PHOSPHORYLASE
(Spirosoma
linguale) 		6 / 10 GLY A 113
GLU A 192
VAL A 208
GLY A 209
MET A 210
THR A 233
 ADE  A 502 (-3.6A)
ADE  A 502 (-2.9A)
ADE  A 502 (-4.5A)
ADE  A 502 (-3.5A)
MPD  A 503 ( 3.2A)
ADE  A 502 (-4.3A)
 0.35A 1pwyE-4lnaA:
37.5		 1pwyE-4lnaA:
46.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4lna PURINE NUCLEOSIDE
PHOSPHORYLASE
(Spirosoma
linguale) 		5 / 10 GLY A 209
GLU A 192
VAL A 186
GLY A 188
VAL A 208
 ADE  A 502 (-3.5A)
ADE  A 502 (-2.9A)
None
None
ADE  A 502 (-4.5A)
 1.16A 1pwyE-4lnaA:
37.5		 1pwyE-4lnaA:
46.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4lna PURINE NUCLEOSIDE
PHOSPHORYLASE
(Spirosoma
linguale) 		6 / 10 GLY A 113
GLU A 192
VAL A 208
GLY A 209
MET A 210
THR A 233
 ADE  A 502 (-3.6A)
ADE  A 502 (-2.9A)
ADE  A 502 (-4.5A)
ADE  A 502 (-3.5A)
MPD  A 503 ( 3.2A)
ADE  A 502 (-4.3A)
 0.26A 1v3qE-4lnaA:
38.5		 1v3qE-4lnaA:
46.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		 4lna PURINE NUCLEOSIDE
PHOSPHORYLASE
(Spirosoma
linguale) 		4 / 4 LEU A 163
PRO A  20
ILE A 268
LEU A 271
 None
 1.13A 1ya4B-4lnaA:
undetectable		 1ya4B-4lnaA:
22.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E9R_A_ACTA700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4lna PURINE NUCLEOSIDE
PHOSPHORYLASE
(Spirosoma
linguale) 		4 / 6 GLY A 113
GLU A 192
GLY A 209
MET A 210
 ADE  A 502 (-3.6A)
ADE  A 502 (-2.9A)
ADE  A 502 (-3.5A)
MPD  A 503 ( 3.2A)
 0.48A 3e9rA-4lnaA:
38.6		 3e9rA-4lnaA:
43.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E9R_C_ACTC700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4lna PURINE NUCLEOSIDE
PHOSPHORYLASE
(Spirosoma
linguale) 		4 / 6 GLY A 113
GLU A 192
GLY A 209
MET A 210
 ADE  A 502 (-3.6A)
ADE  A 502 (-2.9A)
ADE  A 502 (-3.5A)
MPD  A 503 ( 3.2A)
 0.48A 3e9rC-4lnaA:
38.5		 3e9rC-4lnaA:
43.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4lna PURINE NUCLEOSIDE
PHOSPHORYLASE
(Spirosoma
linguale) 		7 / 12 TYR A  83
ALA A 111
GLY A 113
GLU A 192
VAL A 208
GLY A 209
MET A 210
 None
MPD  A 503 ( 4.0A)
ADE  A 502 (-3.6A)
ADE  A 502 (-2.9A)
ADE  A 502 (-4.5A)
ADE  A 502 (-3.5A)
MPD  A 503 ( 3.2A)
 0.32A 3f8wA-4lnaA:
39.3		 3f8wA-4lnaA:
43.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4lna PURINE NUCLEOSIDE
PHOSPHORYLASE
(Spirosoma
linguale) 		7 / 12 HIS A  81
TYR A  83
GLY A 113
GLU A 192
VAL A 208
GLY A 209
MET A 210
 PO4  A 500 (-4.2A)
None
ADE  A 502 (-3.6A)
ADE  A 502 (-2.9A)
ADE  A 502 (-4.5A)
ADE  A 502 (-3.5A)
MPD  A 503 ( 3.2A)
 0.34A 3f8wB-4lnaA:
39.4		 3f8wB-4lnaA:
43.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4lna PURINE NUCLEOSIDE
PHOSPHORYLASE
(Spirosoma
linguale) 		8 / 12 HIS A  81
TYR A  83
ALA A 111
GLY A 113
GLU A 192
VAL A 208
GLY A 209
MET A 210
 PO4  A 500 (-4.2A)
None
MPD  A 503 ( 4.0A)
ADE  A 502 (-3.6A)
ADE  A 502 (-2.9A)
ADE  A 502 (-4.5A)
ADE  A 502 (-3.5A)
MPD  A 503 ( 3.2A)
 0.32A 3f8wC-4lnaA:
39.2		 3f8wC-4lnaA:
43.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_2
(CYTOCHROME P450 3A4)		 4lna PURINE NUCLEOSIDE
PHOSPHORYLASE
(Spirosoma
linguale) 		5 / 9 ILE A 249
THR A 212
LEU A 260
GLU A 257
GLY A  78
 MPD  A 503 ( 4.4A)
None
None
None
None
 0.88A 3nxuB-4lnaA:
undetectable		 3nxuB-4lnaA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_C_ADNC251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4lna PURINE NUCLEOSIDE
PHOSPHORYLASE
(Spirosoma
linguale) 		5 / 12 GLY A 113
VAL A 208
MET A 210
ASP A 234
CYH A 236
 ADE  A 502 (-3.6A)
ADE  A 502 (-4.5A)
MPD  A 503 ( 3.2A)
ADE  A 502 (-2.9A)
ADE  A 502 (-3.4A)
 0.52A 3u40B-4lnaA:
20.6
3u40C-4lnaA:
20.2		 3u40B-4lnaA:
21.81
3u40C-4lnaA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_E_ADNE251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4lna PURINE NUCLEOSIDE
PHOSPHORYLASE
(Spirosoma
linguale) 		5 / 12 GLY A 113
VAL A 208
MET A 210
ASP A 234
CYH A 236
 ADE  A 502 (-3.6A)
ADE  A 502 (-4.5A)
MPD  A 503 ( 3.2A)
ADE  A 502 (-2.9A)
ADE  A 502 (-3.4A)
 0.43A 3u40D-4lnaA:
20.6
3u40E-4lnaA:
20.2		 3u40D-4lnaA:
21.81
3u40E-4lnaA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF512_1
(HEMOLYTIC LECTIN
CEL-III)		 4lna PURINE NUCLEOSIDE
PHOSPHORYLASE
(Spirosoma
linguale) 		4 / 6 THR A 212
ASN A 110
GLY A  27
ILE A  24
 None
None
PO4  A 500 (-3.3A)
None
 1.04A 3w9tF-4lnaA:
undetectable		 3w9tF-4lnaA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 4lna PURINE NUCLEOSIDE
PHOSPHORYLASE
(Spirosoma
linguale) 		5 / 12 GLU A  84
PRO A 189
GLU A 192
THR A 233
GLY A 113
 None
None
ADE  A 502 (-2.9A)
ADE  A 502 (-4.3A)
ADE  A 502 (-3.6A)
 1.17A 5xioA-4lnaA:
2.2		 5xioA-4lnaA:
21.44