SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lnf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_U_9CRU502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4lnf GLUTAMINE SYNTHETASE
(Bacillus
subtilis) 		5 / 12 ALA A 352
PHE A 285
ALA A 408
VAL A 332
ILE A 320
 None
 1.01A 1fm6U-4lnfA:
undetectable		 1fm6U-4lnfA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_A_BEZA1162_0
(PEROXIREDOXIN 5)		 4lnf GLUTAMINE SYNTHETASE
(Bacillus
subtilis) 		5 / 10 PRO A 131
GLY A 130
CYH A 246
LEU A 112
GLY A 203
 None
 1.31A 1h4oA-4lnfA:
undetectable
1h4oB-4lnfA:
undetectable		 1h4oA-4lnfA:
16.03
1h4oB-4lnfA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HO5_A_ADNA1604_1
(5'-NUCLEOTIDASE)		 4lnf GLUTAMINE SYNTHETASE
(Bacillus
subtilis) 		5 / 11 ILE A 275
SER A 268
ARG A 326
ASN A 256
PHE A 258
 None
 1.24A 1ho5A-4lnfA:
undetectable		 1ho5A-4lnfA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_1
(THYMIDYLATE SYNTHASE)		 4lnf GLUTAMINE SYNTHETASE
(Bacillus
subtilis) 		5 / 12 GLU A 419
LEU A 413
ASP A  27
GLY A  59
PHE A  60
 None
 1.06A 2kceA-4lnfA:
undetectable		 2kceA-4lnfA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA502_0
(FERROCHELATASE)		 4lnf GLUTAMINE SYNTHETASE
(Bacillus
subtilis) 		4 / 8 MET A 244
PRO A 291
SER A 295
GLY A  30
 None
 1.08A 2qd3A-4lnfA:
undetectable		 2qd3A-4lnfA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_1
(NEURAMINIDASE A)		 4lnf GLUTAMINE SYNTHETASE
(Bacillus
subtilis) 		5 / 12 ILE A  96
ASP A 107
ASP A  95
TYR A 344
GLN A 212
 None
 1.41A 2ya7B-4lnfA:
undetectable		 2ya7B-4lnfA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_1
(NEURAMINIDASE A)		 4lnf GLUTAMINE SYNTHETASE
(Bacillus
subtilis) 		5 / 12 ILE A  96
ASP A 107
ASP A  95
TYR A 344
GLN A 212
 None
 1.42A 2ya7D-4lnfA:
undetectable		 2ya7D-4lnfA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_1
(PCZA361.24)		 4lnf GLUTAMINE SYNTHETASE
(Bacillus
subtilis) 		3 / 3 ARG A 321
GLU A 189
ASP A 158
 None
GLN  A 503 ( 2.7A)
None
 0.81A 3g2oA-4lnfA:
undetectable		 3g2oA-4lnfA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_0
(UNCHARACTERIZED
PROTEIN)		 4lnf GLUTAMINE SYNTHETASE
(Bacillus
subtilis) 		5 / 12 VAL A  78
ILE A  93
GLN A  24
LEU A 216
ILE A  32
 None
 1.12A 3ijdB-4lnfA:
undetectable		 3ijdB-4lnfA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4lnf GLUTAMINE SYNTHETASE
(Bacillus
subtilis) 		5 / 12 GLU A 419
ASP A  27
LEU A  29
GLY A  59
PHE A  60
 None
 1.20A 3nrrA-4lnfA:
undetectable		 3nrrA-4lnfA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4lnf GLUTAMINE SYNTHETASE
(Bacillus
subtilis) 		5 / 12 GLU A 419
ASP A  27
LEU A  29
GLY A  59
PHE A  60
 None
 1.18A 3nrrB-4lnfA:
undetectable		 3nrrB-4lnfA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD2_1
(CYTOCHROME P450 2D6)		 4lnf GLUTAMINE SYNTHETASE
(Bacillus
subtilis) 		5 / 9 PHE A  92
LEU A  42
VAL A  13
LEU A  74
ILE A   9
 None
 1.18A 3tbgD-4lnfA:
undetectable		 3tbgD-4lnfA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYE_B_YTZB902_1
(DIHYDROPTEROATE
SYNTHASE)		 4lnf GLUTAMINE SYNTHETASE
(Bacillus
subtilis) 		3 / 3 PHE A 428
LYS A 297
SER A 295
 None
 1.30A 3tyeB-4lnfA:
undetectable		 3tyeB-4lnfA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4lnf GLUTAMINE SYNTHETASE
(Bacillus
subtilis) 		4 / 6 LEU A  74
PHE A  77
PHE A  92
LEU A  46
 None
 0.99A 3wg7P-4lnfA:
undetectable
3wg7W-4lnfA:
undetectable		 3wg7P-4lnfA:
19.33
3wg7W-4lnfA:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_B_NCAB1536_0
(DIPHTHERIA TOXIN)		 4lnf GLUTAMINE SYNTHETASE
(Bacillus
subtilis) 		4 / 5 HIS A 188
GLY A 155
TYR A 156
GLU A 196
 None
None
GLN  A 503 (-4.7A)
PO4  A 504 ( 2.8A)
 1.19A 4ae1B-4lnfA:
undetectable		 4ae1B-4lnfA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4lnf GLUTAMINE SYNTHETASE
(Bacillus
subtilis) 		3 / 3 HIS A 245
GLU A 189
ASN A 240
 PO4  A 504 ( 3.1A)
GLN  A 503 ( 2.7A)
GLN  A 503 (-4.6A)
 1.04A 4bupB-4lnfA:
undetectable		 4bupB-4lnfA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_A_D16A301_1
(THYMIDYLATE SYNTHASE)		 4lnf GLUTAMINE SYNTHETASE
(Bacillus
subtilis) 		6 / 12 GLU A 419
LEU A 413
ASP A  27
LEU A  29
GLY A  59
PHE A  60
 None
 1.34A 4foxA-4lnfA:
undetectable		 4foxA-4lnfA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_B_D16B302_1
(THYMIDYLATE SYNTHASE)		 4lnf GLUTAMINE SYNTHETASE
(Bacillus
subtilis) 		5 / 12 GLU A 419
ASP A  27
LEU A  29
GLY A  59
PHE A  60
 None
 1.17A 4foxB-4lnfA:
undetectable		 4foxB-4lnfA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_B_D16B302_1
(THYMIDYLATE SYNTHASE)		 4lnf GLUTAMINE SYNTHETASE
(Bacillus
subtilis) 		5 / 12 GLU A 419
LEU A 413
ASP A  27
GLY A  59
PHE A  60
 None
 1.11A 4foxB-4lnfA:
undetectable		 4foxB-4lnfA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_C_D16C301_1
(THYMIDYLATE SYNTHASE)		 4lnf GLUTAMINE SYNTHETASE
(Bacillus
subtilis) 		5 / 11 GLU A 419
ASP A  27
LEU A  29
GLY A  59
PHE A  60
 None
 1.21A 4foxC-4lnfA:
undetectable		 4foxC-4lnfA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_C_D16C301_1
(THYMIDYLATE SYNTHASE)		 4lnf GLUTAMINE SYNTHETASE
(Bacillus
subtilis) 		5 / 11 GLU A 419
LEU A 413
ASP A  27
GLY A  59
PHE A  60
 None
 1.06A 4foxC-4lnfA:
undetectable		 4foxC-4lnfA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_E_D16E301_1
(THYMIDYLATE SYNTHASE)		 4lnf GLUTAMINE SYNTHETASE
(Bacillus
subtilis) 		5 / 12 GLU A 419
ASP A  27
LEU A  29
GLY A  59
PHE A  60
 None
 1.27A 4foxE-4lnfA:
undetectable		 4foxE-4lnfA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_F_D16F301_1
(THYMIDYLATE SYNTHASE)		 4lnf GLUTAMINE SYNTHETASE
(Bacillus
subtilis) 		5 / 11 GLU A 419
LEU A 413
ASP A  27
GLY A  59
PHE A  60
 None
 1.04A 4foxF-4lnfA:
undetectable		 4foxF-4lnfA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_G_D16G301_1
(THYMIDYLATE SYNTHASE)		 4lnf GLUTAMINE SYNTHETASE
(Bacillus
subtilis) 		6 / 12 GLU A 419
LEU A 413
ASP A  27
LEU A  29
GLY A  59
PHE A  60
 None
 1.34A 4foxG-4lnfA:
undetectable		 4foxG-4lnfA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_D_ACTD305_0
(GLUTATHIONE
TRANSFERASE GTE1)		 4lnf GLUTAMINE SYNTHETASE
(Bacillus
subtilis) 		4 / 4 ILE A 115
LEU A 116
LYS A 117
ASN A 111
 None
 1.33A 4g19D-4lnfA:
undetectable		 4g19D-4lnfA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJQ_D_ERYD1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4lnf GLUTAMINE SYNTHETASE
(Bacillus
subtilis) 		5 / 12 PHE A 136
ASP A 198
ARG A 335
GLU A 333
GLU A 132
 None
PO4  A 504 ( 4.9A)
GLN  A 503 ( 4.8A)
MG  A 502 (-2.3A)
PO4  A 504 ( 2.3A)
 0.93A 4zjqD-4lnfA:
2.7		 4zjqD-4lnfA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQY_A_BEZA401_0
(THIOREDOXIN)		 4lnf GLUTAMINE SYNTHETASE
(Bacillus
subtilis) 		4 / 8 ILE A  21
PHE A  92
GLN A  24
CYH A  94
 None
 1.03A 5dqyA-4lnfA:
undetectable		 5dqyA-4lnfA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_D_CCSD14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2
PROGRAMMED CELL
DEATH 1 LIGAND 1)		 4lnf GLUTAMINE SYNTHETASE
(Bacillus
subtilis) 		5 / 12 LEU A 299
GLY A 241
GLU A 134
GLY A 243
ARG A 335
 None
None
GLN  A 503 (-3.0A)
GLN  A 503 ( 4.6A)
GLN  A 503 ( 4.8A)
 1.08A 5o4yD-4lnfA:
undetectable
5o4yE-4lnfA:
undetectable		 5o4yD-4lnfA:
2.11
5o4yE-4lnfA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4lnf GLUTAMINE SYNTHETASE
(Bacillus
subtilis) 		4 / 7 PHE A 181
VAL A 217
ILE A  79
THR A 213
 None
 1.01A 5vkqA-4lnfA:
undetectable
5vkqD-4lnfA:
undetectable		 5vkqA-4lnfA:
14.44
5vkqD-4lnfA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1802_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4lnf GLUTAMINE SYNTHETASE
(Bacillus
subtilis) 		4 / 7 THR A 213
PHE A 181
VAL A 217
ILE A  79
 None
 1.03A 5vkqA-4lnfA:
undetectable
5vkqB-4lnfA:
undetectable		 5vkqA-4lnfA:
14.44
5vkqB-4lnfA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4lnf GLUTAMINE SYNTHETASE
(Bacillus
subtilis) 		4 / 8 THR A 213
PHE A 181
VAL A 217
ILE A  79
 None
 1.02A 5vkqB-4lnfA:
undetectable
5vkqC-4lnfA:
undetectable		 5vkqB-4lnfA:
14.44
5vkqC-4lnfA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4lnf GLUTAMINE SYNTHETASE
(Bacillus
subtilis) 		4 / 7 THR A 213
PHE A 181
VAL A 217
ILE A  79
 None
 1.01A 5vkqC-4lnfA:
undetectable
5vkqD-4lnfA:
undetectable		 5vkqC-4lnfA:
14.44
5vkqD-4lnfA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 4lnf GLUTAMINE SYNTHETASE
(Bacillus
subtilis) 		3 / 3 HIS A 245
GLU A 189
ASN A 240
 PO4  A 504 ( 3.1A)
GLN  A 503 ( 2.7A)
GLN  A 503 (-4.6A)
 0.98A 5wbvA-4lnfA:
undetectable		 5wbvA-4lnfA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 4lnf GLUTAMINE SYNTHETASE
(Bacillus
subtilis) 		3 / 3 HIS A 245
GLU A 189
ASN A 240
 PO4  A 504 ( 3.1A)
GLN  A 503 ( 2.7A)
GLN  A 503 (-4.6A)
 0.98A 5wbvB-4lnfA:
undetectable		 5wbvB-4lnfA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB5_A_NMYA301_0
(AAC(3)-IIIB PROTEIN)		 4lnf GLUTAMINE SYNTHETASE
(Bacillus
subtilis) 		5 / 11 ASN A 342
ASP A  27
THR A  26
GLY A 106
GLU A  58
 None
None
None
None
MG  A 505 ( 4.4A)
 1.27A 6mb5A-4lnfA:
undetectable		 6mb5A-4lnfA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 4lnf GLUTAMINE SYNTHETASE
(Bacillus
subtilis) 		5 / 12 LEU A 413
ASP A  27
LEU A  29
GLY A  59
PHE A  60
 None
 1.31A 6r2eA-4lnfA:
undetectable		 6r2eA-4lnfA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)		 4lnf GLUTAMINE SYNTHETASE
(Bacillus
subtilis) 		5 / 11 LEU A 413
ASP A  27
LEU A  29
GLY A  59
PHE A  60
 None
 1.33A 6r2eG-4lnfA:
undetectable		 6r2eG-4lnfA:
20.82