SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lns'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_E_GCSE710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 4lns ASPARAGINE
SYNTHETASE A
(Trypanosoma
brucei) 		4 / 8 TRP A 340
SER A 320
ILE A 332
ASP A 118
 None
 1.08A 2xadA-4lnsA:
undetectable		 2xadA-4lnsA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_F_GCSF710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 4lns ASPARAGINE
SYNTHETASE A
(Trypanosoma
brucei) 		4 / 8 TRP A 340
SER A 320
ILE A 332
ASP A 118
 None
 1.11A 2xadB-4lnsA:
undetectable		 2xadB-4lnsA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_G_GCSG710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 4lns ASPARAGINE
SYNTHETASE A
(Trypanosoma
brucei) 		4 / 8 TRP A 340
SER A 320
ILE A 332
ASP A 118
 None
 1.08A 2xadC-4lnsA:
undetectable		 2xadC-4lnsA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_H_GCSH710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 4lns ASPARAGINE
SYNTHETASE A
(Trypanosoma
brucei) 		4 / 8 TRP A 340
SER A 320
ILE A 332
ASP A 118
 None
 1.09A 2xadD-4lnsA:
undetectable		 2xadD-4lnsA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LMY_A_CP6A562_1
(BETA-HEXOSAMINIDASE
SUBUNIT BETA)		 4lns ASPARAGINE
SYNTHETASE A
(Trypanosoma
brucei) 		5 / 12 ARG A 321
ASP A 107
HIS A 113
ASP A 257
LEU A 201
 None
 1.27A 3lmyA-4lnsA:
undetectable		 3lmyA-4lnsA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 4lns ASPARAGINE
SYNTHETASE A
(Trypanosoma
brucei) 		5 / 12 GLY A 333
PHE A 325
ASN A 262
THR A 264
LEU A 265
 None
 1.23A 5lsuB-4lnsA:
undetectable		 5lsuB-4lnsA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MQT_C_STIC302_1
(DEOXYCYTIDINE KINASE)		 4lns ASPARAGINE
SYNTHETASE A
(Trypanosoma
brucei) 		5 / 12 ILE A 163
MET A 324
GLU A 334
LEU A 265
GLU A 151
 None
 1.34A 5mqtC-4lnsA:
undetectable		 5mqtC-4lnsA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4lns ASPARAGINE
SYNTHETASE A
(Trypanosoma
brucei) 		5 / 12 LYS A 247
LEU A  33
GLY A 316
SER A 273
PHE A 200
 None
 1.15A 5vooB-4lnsA:
undetectable		 5vooB-4lnsA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 4lns ASPARAGINE
SYNTHETASE A
(Trypanosoma
brucei) 		5 / 10 HIS A 113
GLU A 270
GLY A 318
ARG A 321
ILE A 332
 None
 0.66A 6bniA-4lnsA:
20.9		 6bniA-4lnsA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 4lns ASPARAGINE
SYNTHETASE A
(Trypanosoma
brucei) 		5 / 10 HIS A 113
GLU A 270
GLY A 318
ARG A 321
ILE A 332
 None
 0.63A 6bniB-4lnsA:
21.0		 6bniB-4lnsA:
13.79