SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lnz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_1
(MINERALOCORTICOID
RECEPTOR)		 4lnz UNCONVENTIONAL
MYOSIN-VB
(Homo
sapiens) 		5 / 12 LEU A1778
ASN A1777
SER A1768
LEU A1767
LEU A1810
 None
 1.35A 1ya3B-4lnzA:
undetectable		 1ya3B-4lnzA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_B_T44B1395_1
(THYROXINE-BINDING
GLOBULIN)		 4lnz UNCONVENTIONAL
MYOSIN-VB
(Homo
sapiens) 		5 / 10 ALA A1620
LEU A1740
LEU A1712
SER A1619
ASN A1696
 None
 1.41A 2ceoB-4lnzA:
undetectable		 2ceoB-4lnzA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4lnz UNCONVENTIONAL
MYOSIN-VB
(Homo
sapiens) 		4 / 8 THR A1769
GLN A1798
GLN A1771
ASP A1806
 None
 1.25A 2xz5C-4lnzA:
undetectable
2xz5D-4lnzA:
undetectable		 2xz5C-4lnzA:
20.71
2xz5D-4lnzA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA202_1
(PROTEIN S100-A4)		 4lnz UNCONVENTIONAL
MYOSIN-VB
(Homo
sapiens) 		5 / 12 LEU A1524
SER A1523
ILE A1481
LEU A1480
ASP A1476
 None
 1.22A 3ko0A-4lnzA:
1.6
3ko0B-4lnzA:
1.7
3ko0C-4lnzA:
1.7
3ko0D-4lnzA:
1.6		 3ko0A-4lnzA:
14.90
3ko0B-4lnzA:
14.90
3ko0C-4lnzA:
14.90
3ko0D-4lnzA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ202_1
(PROTEIN S100-A4)		 4lnz UNCONVENTIONAL
MYOSIN-VB
(Homo
sapiens) 		5 / 11 LEU A1480
ASP A1476
LEU A1524
SER A1523
ILE A1481
 None
 1.20A 3ko0A-4lnzA:
1.6
3ko0B-4lnzA:
1.7
3ko0I-4lnzA:
1.7
3ko0J-4lnzA:
1.6		 3ko0A-4lnzA:
14.90
3ko0B-4lnzA:
14.90
3ko0I-4lnzA:
14.90
3ko0J-4lnzA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK202_1
(PROTEIN S100-A4)		 4lnz UNCONVENTIONAL
MYOSIN-VB
(Homo
sapiens) 		5 / 12 LEU A1524
SER A1523
ILE A1481
LEU A1480
ASP A1476
 None
 1.17A 3ko0K-4lnzA:
1.7
3ko0L-4lnzA:
1.7
3ko0S-4lnzA:
1.6
3ko0T-4lnzA:
1.7		 3ko0K-4lnzA:
14.90
3ko0L-4lnzA:
14.90
3ko0S-4lnzA:
14.90
3ko0T-4lnzA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL202_1
(PROTEIN S100-A4)		 4lnz UNCONVENTIONAL
MYOSIN-VB
(Homo
sapiens) 		5 / 12 LEU A1480
ASP A1476
LEU A1524
SER A1523
ILE A1481
 None
 1.20A 3ko0K-4lnzA:
1.7
3ko0L-4lnzA:
1.7
3ko0M-4lnzA:
1.7
3ko0N-4lnzA:
1.6		 3ko0K-4lnzA:
14.90
3ko0L-4lnzA:
14.90
3ko0M-4lnzA:
14.90
3ko0N-4lnzA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM202_1
(PROTEIN S100-A4)		 4lnz UNCONVENTIONAL
MYOSIN-VB
(Homo
sapiens) 		5 / 12 LEU A1524
SER A1523
ILE A1481
LEU A1480
ASP A1476
 None
 1.20A 3ko0M-4lnzA:
1.7
3ko0N-4lnzA:
1.6
3ko0O-4lnzA:
1.7
3ko0P-4lnzA:
1.7		 3ko0M-4lnzA:
14.90
3ko0N-4lnzA:
14.90
3ko0O-4lnzA:
14.90
3ko0P-4lnzA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP202_1
(PROTEIN S100-A4)		 4lnz UNCONVENTIONAL
MYOSIN-VB
(Homo
sapiens) 		5 / 12 LEU A1480
ASP A1476
LEU A1524
SER A1523
ILE A1481
 None
 1.22A 3ko0M-4lnzA:
1.6
3ko0N-4lnzA:
1.6
3ko0O-4lnzA:
1.7
3ko0P-4lnzA:
1.6		 3ko0M-4lnzA:
14.90
3ko0N-4lnzA:
14.90
3ko0O-4lnzA:
14.90
3ko0P-4lnzA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3003_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4lnz UNCONVENTIONAL
MYOSIN-VB
(Homo
sapiens) 		4 / 6 ILE A1678
VAL A1681
LEU A1685
HIS A1665
 None
 0.80A 3kp6A-4lnzA:
undetectable
3kp6B-4lnzA:
undetectable		 3kp6A-4lnzA:
17.10
3kp6B-4lnzA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)		 4lnz UNCONVENTIONAL
MYOSIN-VB
(Homo
sapiens) 		3 / 3 ASP A1513
ASN A1516
SER A1564
 None
 0.84A 3lslA-4lnzA:
undetectable
3lslD-4lnzA:
undetectable		 3lslA-4lnzA:
20.60
3lslD-4lnzA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID802_0
(GLUTAMATE RECEPTOR 2)		 4lnz UNCONVENTIONAL
MYOSIN-VB
(Homo
sapiens) 		3 / 3 SER A1564
ASP A1513
ASN A1516
 None
 0.85A 3lslA-4lnzA:
undetectable
3lslD-4lnzA:
undetectable		 3lslA-4lnzA:
20.60
3lslD-4lnzA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 4lnz UNCONVENTIONAL
MYOSIN-VB
(Homo
sapiens) 		5 / 12 MET A1737
LEU A1740
ALA A1744
LEU A1622
ILE A1689
 None
 1.13A 3olsB-4lnzA:
undetectable		 3olsB-4lnzA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4lnz UNCONVENTIONAL
MYOSIN-VB
(Homo
sapiens) 		4 / 4 GLN A1735
THR A1736
LEU A1728
LEU A1723
 None
 1.20A 5m5kB-4lnzA:
undetectable		 5m5kB-4lnzA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_F_EY4F500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4lnz UNCONVENTIONAL
MYOSIN-VB
(Homo
sapiens) 		4 / 7 ALA A1609
ILE A1677
GLN A1680
VAL A1681
 None
 0.88A 6cduF-4lnzA:
undetectable
6cduJ-4lnzA:
2.7		 6cduF-4lnzA:
22.73
6cduJ-4lnzA:
22.73