SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4loa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4loa DE-NOVO DESIGN
AMIDASE
(synthetic
construct) 		3 / 3 THR A 134
SER A  13
LYS A  17
 None
 0.95A 3aocC-4loaA:
undetectable		 3aocC-4loaA:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_1
(CYTOCHROME P450 1A1)		 4loa DE-NOVO DESIGN
AMIDASE
(synthetic
construct) 		3 / 3 SER A  35
SER A  81
ALA A  59
 None
 0.73A 6dwnC-4loaA:
undetectable		 6dwnC-4loaA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_C_ADNC501_2
(-)		 4loa DE-NOVO DESIGN
AMIDASE
(synthetic
construct) 		4 / 5 THR A  80
THR A 134
HIS A 130
GLY A  14
 None
None
None
CL  A 201 ( 4.7A)
 1.12A 6gbnC-4loaA:
undetectable		 6gbnC-4loaA:
16.32