SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4log'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_A_IPBA600_0
(ODORANT-BINDING
PROTEIN)		 4log MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN
AND NR2E3 PROTEIN
CHIMERIC CONSTRUCT
(Escherichia
coli;
Homo
sapiens) 		4 / 6 VAL A  10
VAL A  52
ILE A  62
ASN A 269
 None
 0.95A 1e06A-4logA:
undetectable		 1e06A-4logA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GWR_A_ESTA600_1
(OESTROGEN RECEPTOR)		 4log MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN
AND NR2E3 PROTEIN
CHIMERIC CONSTRUCT
(Escherichia
coli;
Homo
sapiens) 		5 / 10 LEU A1295
ALA A1296
GLU A1299
LEU A1389
LEU A1388
 None
 0.90A 1gwrA-4logA:
14.6		 1gwrA-4logA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2888_0
(AMINOMETHYLTRANSFERA
SE)		 4log MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN
AND NR2E3 PROTEIN
CHIMERIC CONSTRUCT
(Escherichia
coli;
Homo
sapiens) 		5 / 10 LEU A 194
LEU A 197
ILE A 163
GLU A 155
LEU A 153
 None
 1.14A 1wopA-4logA:
undetectable		 1wopA-4logA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF211_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4log MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN
AND NR2E3 PROTEIN
CHIMERIC CONSTRUCT
(Escherichia
coli;
Homo
sapiens) 		4 / 7 LEU A1263
PHE A1310
LEU A1375
SER A1357
 None
 1.01A 1wrlE-4logA:
undetectable
1wrlF-4logA:
undetectable		 1wrlE-4logA:
12.08
1wrlF-4logA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ1_A_HLTA2001_1
(FERRITIN LIGHT CHAIN)		 4log MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN
AND NR2E3 PROTEIN
CHIMERIC CONSTRUCT
(Escherichia
coli;
Homo
sapiens) 		4 / 4 LEU A 306
SER A 308
TYR A 309
LEU A 292
 None
 1.28A 1xz1A-4logA:
2.9		 1xz1A-4logA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		 4log MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN
AND NR2E3 PROTEIN
CHIMERIC CONSTRUCT
(Escherichia
coli;
Homo
sapiens) 		4 / 4 LEU A 306
SER A 308
TYR A 309
LEU A 292
 None
 1.28A 1xz3A-4logA:
3.1		 1xz3A-4logA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4log MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN
AND NR2E3 PROTEIN
CHIMERIC CONSTRUCT
(Escherichia
coli;
Homo
sapiens) 		5 / 11 ALA A 305
ILE A 110
VAL A  99
LEU A  78
ILE A  81
 None
 1.13A 2h42A-4logA:
undetectable		 2h42A-4logA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_A_REAA1445_1
(PUTATIVE CYTOCHROME
P450 120)		 4log MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN
AND NR2E3 PROTEIN
CHIMERIC CONSTRUCT
(Escherichia
coli;
Homo
sapiens) 		5 / 12 ALA A 266
LEU A 282
PHE A 281
VAL A 295
GLY A  18
 None
 1.08A 2ve3A-4logA:
undetectable		 2ve3A-4logA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_C_VDYC6178_1
(VITAMIN D
HYDROXYLASE)		 4log MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN
AND NR2E3 PROTEIN
CHIMERIC CONSTRUCT
(Escherichia
coli;
Homo
sapiens) 		5 / 12 ILE A 110
LEU A 264
ILE A  61
VAL A  25
LEU A  22
 None
 0.93A 3a51C-4logA:
1.9		 3a51C-4logA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_A_BEZA302_0
(DISULFIDE
INTERCHANGE PROTEIN)		 4log MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN
AND NR2E3 PROTEIN
CHIMERIC CONSTRUCT
(Escherichia
coli;
Homo
sapiens) 		4 / 6 PRO A 128
LEU A 149
ALA A 225
PRO A 127
 None
 1.25A 3gv1A-4logA:
undetectable
3gv1C-4logA:
undetectable		 3gv1A-4logA:
12.63
3gv1C-4logA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB301_0
(DISULFIDE
INTERCHANGE PROTEIN)		 4log MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN
AND NR2E3 PROTEIN
CHIMERIC CONSTRUCT
(Escherichia
coli;
Homo
sapiens) 		4 / 6 LEU A 149
ALA A 225
PRO A 127
PRO A 128
 None
 1.21A 3gv1A-4logA:
undetectable
3gv1B-4logA:
undetectable		 3gv1A-4logA:
12.63
3gv1B-4logA:
12.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_2
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 4log MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN
AND NR2E3 PROTEIN
CHIMERIC CONSTRUCT
(Escherichia
coli;
Homo
sapiens) 		4 / 7 GLU A 155
TYR A 157
MET A 332
TRP A 342
 None
 0.68A 3jyrA-4logA:
41.1		 3jyrA-4logA:
61.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_DIFB585_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4log MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN
AND NR2E3 PROTEIN
CHIMERIC CONSTRUCT
(Escherichia
coli;
Homo
sapiens) 		5 / 12 VAL A 198
LEU A 162
GLY A 189
ALA A 190
LEU A 363
 None
 1.08A 3n8yB-4logA:
undetectable		 3n8yB-4logA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ1_X_DXCX75_0
(CYTOCHROME C7)		 4log MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN
AND NR2E3 PROTEIN
CHIMERIC CONSTRUCT
(Escherichia
coli;
Homo
sapiens) 		4 / 6 ILE A  11
LEU A   9
LYS A  28
PHE A  29
 None
 0.96A 3sj1X-4logA:
undetectable		 3sj1X-4logA:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_1
(HIV-1 PROTEASE)		 4log MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN
AND NR2E3 PROTEIN
CHIMERIC CONSTRUCT
(Escherichia
coli;
Homo
sapiens) 		6 / 11 GLY A 302
ALA A 303
VAL A 261
GLY A 262
THR A  95
PRO A 109
 None
 1.30A 3ufnA-4logA:
undetectable		 3ufnA-4logA:
11.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VFJ_A_ACTA410_0
(MALTOSE-BINDING
PERIPLASMIC PROTEIN,
C-TERMINAL FUSED BY
CYS-LYS-D-ALA-D-ALA)		 4log MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN
AND NR2E3 PROTEIN
CHIMERIC CONSTRUCT
(Escherichia
coli;
Homo
sapiens) 		4 / 4 LYS A  17
ALA A  65
GLU A 113
LEU A 264
 None
 0.46A 3vfjA-4logA:
45.5		 3vfjA-4logA:
75.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_1
(MNMC2)		 4log MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN
AND NR2E3 PROTEIN
CHIMERIC CONSTRUCT
(Escherichia
coli;
Homo
sapiens) 		4 / 5 GLU A 310
ASP A 316
ASP A 289
ASN A 296
 None
 1.41A 3vywD-4logA:
undetectable		 3vywD-4logA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_A_ACHA301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4log MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN
AND NR2E3 PROTEIN
CHIMERIC CONSTRUCT
(Escherichia
coli;
Homo
sapiens) 		4 / 7 TYR A 157
TRP A 342
ARG A  68
MET A 338
 None
 1.40A 3wipA-4logA:
undetectable
3wipB-4logA:
undetectable		 3wipA-4logA:
16.73
3wipB-4logA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_D_ACHD301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4log MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN
AND NR2E3 PROTEIN
CHIMERIC CONSTRUCT
(Escherichia
coli;
Homo
sapiens) 		4 / 8 TYR A 157
TRP A 342
ARG A  68
MET A 338
 None
 1.35A 3wipD-4logA:
undetectable
3wipE-4logA:
undetectable		 3wipD-4logA:
16.73
3wipE-4logA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_F_ACHF301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4log MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN
AND NR2E3 PROTEIN
CHIMERIC CONSTRUCT
(Escherichia
coli;
Homo
sapiens) 		4 / 7 TYR A 157
TRP A 342
ARG A  68
MET A 338
 None
 1.40A 3wipF-4logA:
undetectable
3wipG-4logA:
undetectable		 3wipF-4logA:
16.73
3wipG-4logA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_J_ACHJ301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4log MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN
AND NR2E3 PROTEIN
CHIMERIC CONSTRUCT
(Escherichia
coli;
Homo
sapiens) 		4 / 8 ARG A  68
MET A 338
TYR A 157
TRP A 342
 None
 1.24A 3wipF-4logA:
undetectable
3wipJ-4logA:
undetectable		 3wipF-4logA:
16.73
3wipJ-4logA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HC3_A_DXCA75_0
(PPCA)		 4log MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN
AND NR2E3 PROTEIN
CHIMERIC CONSTRUCT
(Escherichia
coli;
Homo
sapiens) 		4 / 7 ILE A  11
LEU A   9
LYS A  28
PHE A  29
 None
 1.02A 4hc3A-4logA:
undetectable		 4hc3A-4logA:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_G_TMQG202_1
(DIHYDROFOLATE
REDUCTASE)		 4log MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN
AND NR2E3 PROTEIN
CHIMERIC CONSTRUCT
(Escherichia
coli;
Homo
sapiens) 		5 / 12 ILE A 268
ILE A 110
LEU A  22
VAL A  25
ILE A  61
 None
 1.02A 4m2xG-4logA:
undetectable		 4m2xG-4logA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4log MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN
AND NR2E3 PROTEIN
CHIMERIC CONSTRUCT
(Escherichia
coli;
Homo
sapiens) 		4 / 5 ASN A 269
ALA A  53
GLY A  58
ASP A  16
 None
 0.98A 4n48A-4logA:
undetectable		 4n48A-4logA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_A_ESTA2000_1
(ESTROGEN RECEPTOR)		 4log MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN
AND NR2E3 PROTEIN
CHIMERIC CONSTRUCT
(Escherichia
coli;
Homo
sapiens) 		5 / 12 LEU A1295
ALA A1296
GLU A1299
LEU A1389
LEU A1388
 None
 0.97A 4pxmA-4logA:
14.0		 4pxmA-4logA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXG_B_ESTB601_1
(ESTROGEN RECEPTOR)		 4log MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN
AND NR2E3 PROTEIN
CHIMERIC CONSTRUCT
(Escherichia
coli;
Homo
sapiens) 		5 / 11 LEU A1295
ALA A1296
GLU A1299
LEU A1389
LEU A1388
 None
 0.96A 5dxgB-4logA:
14.3		 5dxgB-4logA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_1
(ESTROGEN RECEPTOR)		 4log MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN
AND NR2E3 PROTEIN
CHIMERIC CONSTRUCT
(Escherichia
coli;
Homo
sapiens) 		5 / 12 THR A1294
LEU A1295
ALA A1296
GLU A1299
LEU A1388
 None
 1.13A 5gs4A-4logA:
14.7		 5gs4A-4logA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_2
(PROTEASE PR5-SQV)		 4log MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN
AND NR2E3 PROTEIN
CHIMERIC CONSTRUCT
(Escherichia
coli;
Homo
sapiens) 		5 / 11 ARG A 100
ALA A  79
ILE A  61
PRO A 109
ILE A  81
 None
 1.05A 5kr2B-4logA:
undetectable		 5kr2B-4logA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_A_NIZA808_1
(CATALASE-PEROXIDASE)		 4log MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN
AND NR2E3 PROTEIN
CHIMERIC CONSTRUCT
(Escherichia
coli;
Homo
sapiens) 		4 / 8 VAL A 345
GLY A 193
LEU A 197
THR A 195
 None
 0.95A 5sxqA-4logA:
undetectable		 5sxqA-4logA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_B_NIZB808_1
(CATALASE-PEROXIDASE)		 4log MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN
AND NR2E3 PROTEIN
CHIMERIC CONSTRUCT
(Escherichia
coli;
Homo
sapiens) 		4 / 8 VAL A 345
GLY A 193
LEU A 197
THR A 195
 None
 0.98A 5sxqB-4logA:
undetectable		 5sxqB-4logA:
24.25