SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lom'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A  86
GLN A  89
LEU A  28
ALA A  13
VAL A 186
 None
 0.96A 1fbyA-4lomA:
undetectable		 1fbyA-4lomA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_B_9CRB1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A  86
GLN A  89
LEU A  28
ALA A  13
VAL A 186
 None
 0.97A 1fbyB-4lomA:
undetectable		 1fbyB-4lomA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZ4_A_BEZA784_0
(MALT REGULATORY
PROTEIN)		 4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Mycobacterium
tuberculosis) 		4 / 6 HIS A 113
LEU A 170
LEU A 111
PRO A 106
 None
 1.12A 1hz4A-4lomA:
undetectable		 1hz4A-4lomA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_C_T44C128_1
(TRANSTHYRETIN)		 4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Mycobacterium
tuberculosis) 		5 / 11 LEU A  49
ALA A  80
ALA A  64
THR A  40
VAL A  38
 None
 1.16A 1ictA-4lomA:
undetectable
1ictC-4lomA:
undetectable		 1ictA-4lomA:
20.28
1ictC-4lomA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_B_THAB2_1
(LIVER
CARBOXYLESTERASE I)		 4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Mycobacterium
tuberculosis) 		5 / 11 LEU A  28
VAL A 116
LEU A  91
LEU A 118
LEU A  83
 None
 1.24A 1mx1B-4lomA:
undetectable		 1mx1B-4lomA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_A_TEIA3006_1
(XANTHINE
DEHYDROGENASE)		 4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  91
LEU A  87
VAL A 116
ALA A  56
ALA A 187
 None
 1.03A 1n5xA-4lomA:
undetectable		 1n5xA-4lomA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_B_TEIB4006_1
(XANTHINE
DEHYDROGENASE)		 4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  91
LEU A  87
VAL A 116
ALA A  56
ALA A 187
 None
 1.03A 1n5xB-4lomA:
undetectable		 1n5xB-4lomA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Mycobacterium
tuberculosis) 		3 / 3 GLU A  77
HIS A  73
HIS A 152
 MN  A 302 ( 2.6A)
MN  A 302 ( 3.4A)
MN  A 302 (-3.4A)
 0.42A 1oe2A-4lomA:
undetectable		 1oe2A-4lomA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Mycobacterium
tuberculosis) 		3 / 3 GLU A 180
HIS A 176
HIS A  47
 IYP  A 301 ( 2.6A)
MN  A 303 ( 3.4A)
MN  A 303 ( 3.6A)
 0.39A 1oe2A-4lomA:
undetectable		 1oe2A-4lomA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_A_REAA502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A  86
GLN A  89
LEU A  28
ALA A  13
LEU A 165
 None
 0.78A 2aclA-4lomA:
undetectable
2aclE-4lomA:
undetectable		 2aclA-4lomA:
20.97
2aclE-4lomA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_1
(POL POLYPROTEIN)		 4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 165
GLY A  84
ALA A 161
VAL A 116
ILE A 163
 None
 0.75A 2avvA-4lomA:
undetectable		 2avvA-4lomA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_3
(POL POLYPROTEIN)		 4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 165
GLY A  84
ALA A 161
VAL A 116
ILE A 163
 None
 0.74A 2avvE-4lomA:
undetectable		 2avvE-4lomA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F80_B_017B301_1
(POL POLYPROTEIN)		 4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 165
GLY A  84
ALA A 161
VAL A 116
ILE A 163
 None
 0.85A 2f80A-4lomA:
undetectable		 2f80A-4lomA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F80_B_017B301_2
(POL POLYPROTEIN)		 4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 165
GLY A  84
ALA A 161
VAL A 116
ILE A 163
 None
 0.82A 2f80B-4lomA:
undetectable		 2f80B-4lomA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F81_A_017A302_1
(POL POLYPROTEIN)		 4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 165
GLY A  84
ALA A 161
VAL A 116
ILE A 163
 None
 0.92A 2f81A-4lomA:
undetectable		 2f81A-4lomA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_A_017A201_2
(PROTEASE)		 4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 165
GLY A  84
ALA A 161
VAL A 116
ILE A 163
 None
 0.87A 2hs2B-4lomA:
undetectable		 2hs2B-4lomA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_2
(PROTEASE)		 4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 165
GLY A  84
ALA A 161
VAL A 116
ILE A 163
 None
 0.97A 2ienB-4lomA:
undetectable		 2ienB-4lomA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 165
GLY A  84
ALA A 161
VAL A 116
ILE A 163
 None
 0.87A 2pymA-4lomA:
undetectable		 2pymA-4lomA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 165
GLY A  84
ALA A 161
VAL A 116
ILE A 163
 None
 0.85A 2pymB-4lomA:
undetectable		 2pymB-4lomA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 165
GLY A  84
ALA A 161
VAL A 116
ILE A 163
 None
 0.89A 2pynA-4lomA:
undetectable		 2pynA-4lomA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 165
GLY A  84
ALA A 161
VAL A 116
ILE A 163
 None
 0.88A 2pynB-4lomA:
undetectable		 2pynB-4lomA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 165
GLY A  84
ALA A 161
VAL A 116
ILE A 163
 None
 0.85A 2q63B-4lomA:
undetectable		 2q63B-4lomA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYW_A_017A201_1
(HIV-1 PROTEASE)		 4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 165
GLY A  84
ALA A 161
VAL A 116
ILE A 163
 None
 0.90A 3cywA-4lomA:
undetectable		 3cywA-4lomA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYW_A_017A201_2
(HIV-1 PROTEASE)		 4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 165
GLY A  84
ALA A 161
VAL A 116
ILE A 163
 None
 0.82A 3cywB-4lomA:
undetectable		 3cywB-4lomA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1X_A_ROCA201_2
(HIV-1 PROTEASE)		 4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 165
GLY A  84
ALA A 161
VAL A 116
ILE A 163
 None
 0.84A 3d1xB-4lomA:
undetectable		 3d1xB-4lomA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D20_A_017A201_1
(HIV-1 PROTEASE)		 4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 165
GLY A  84
ALA A 161
VAL A 116
ILE A 163
 None
 0.91A 3d20A-4lomA:
undetectable		 3d20A-4lomA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D20_A_017A201_2
(HIV-1 PROTEASE)		 4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 165
GLY A  84
ALA A 161
VAL A 116
ILE A 163
 None
 0.87A 3d20B-4lomA:
undetectable		 3d20B-4lomA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_1
(PROTEASE)		 4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Mycobacterium
tuberculosis) 		5 / 10 LEU A 165
GLY A  84
ALA A 161
VAL A 116
ILE A 163
 None
 0.85A 3em3A-4lomA:
undetectable		 3em3A-4lomA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A  86
GLN A  89
LEU A  28
ALA A  13
VAL A 186
 None
 0.94A 3fc6C-4lomA:
undetectable		 3fc6C-4lomA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  84
LEU A  49
VAL A  62
ILE A  26
LEU A 165
 None
 1.27A 3g9eA-4lomA:
undetectable		 3g9eA-4lomA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JVY_B_017B401_2
(GAG-POL POLYPROTEIN)		 4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 165
GLY A  84
ALA A 161
VAL A 116
ILE A 163
 None
 0.85A 3jvyB-4lomA:
undetectable		 3jvyB-4lomA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_3
(HIV-1 PROTEASE)		 4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 165
GLY A  84
ALA A 161
VAL A 116
ILE A 163
 None
 0.91A 3k4vD-4lomA:
undetectable		 3k4vD-4lomA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZS_A_017A200_1
(HIV-1 PROTEASE)		 4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 165
GLY A  84
ALA A 161
VAL A 116
ILE A 163
 None
 0.85A 3lzsA-4lomA:
undetectable		 3lzsA-4lomA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZS_A_017A200_2
(HIV-1 PROTEASE)		 4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 165
GLY A  84
ALA A 161
VAL A 116
ILE A 163
 None
 0.90A 3lzsB-4lomA:
undetectable		 3lzsB-4lomA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_1
(HIV-1 PROTEASE)		 4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 165
GLY A  84
ALA A 161
VAL A 116
ILE A 163
 None
 0.89A 3lzuA-4lomA:
undetectable		 3lzuA-4lomA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_D_ROCD100_1
(PROTEASE)		 4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 165
GLY A  84
ALA A 161
VAL A 116
ILE A 163
 None
 0.87A 3ndtC-4lomA:
undetectable		 3ndtC-4lomA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_D_ROCD100_2
(PROTEASE)		 4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 165
GLY A  84
ALA A 161
VAL A 116
ILE A 163
 None
 0.90A 3ndtD-4lomA:
undetectable		 3ndtD-4lomA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_A_ROCA101_1
(PROTEASE)		 4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 165
GLY A  84
ALA A 161
VAL A 116
ILE A 163
 None
 0.86A 3nduA-4lomA:
undetectable		 3nduA-4lomA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_A_ROCA101_2
(PROTEASE)		 4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 165
GLY A  84
ALA A 161
VAL A 116
ILE A 163
 None
 0.84A 3nduB-4lomA:
undetectable		 3nduB-4lomA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_2
(PROTEASE)		 4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 165
GLY A  84
ALA A 161
VAL A 116
ILE A 163
 None
 0.89A 3nduD-4lomA:
undetectable		 3nduD-4lomA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_2
(PROTEASE)		 4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Mycobacterium
tuberculosis) 		5 / 10 LEU A 165
GLY A  84
ALA A 161
VAL A 116
ILE A 163
 None
 0.95A 3nu6B-4lomA:
undetectable		 3nu6B-4lomA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_1
(HIV-1 PROTEASE)		 4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Mycobacterium
tuberculosis) 		5 / 9 LEU A 165
GLY A  84
ALA A 161
VAL A 116
ILE A 163
 None
 0.83A 3oxvA-4lomA:
undetectable		 3oxvA-4lomA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWM_B_017B402_1
(PROTEASE)		 4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 165
GLY A  84
ALA A 161
VAL A 116
ILE A 163
 None
 0.83A 3pwmA-4lomA:
undetectable		 3pwmA-4lomA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWM_B_017B402_2
(PROTEASE)		 4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 165
GLY A  84
ALA A 161
VAL A 116
ILE A 163
 None
 0.97A 3pwmB-4lomA:
undetectable		 3pwmB-4lomA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_3
(PROTEASE)		 4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 165
GLY A  84
ALA A 161
VAL A 116
ILE A 163
 None
 0.85A 3pwrB-4lomA:
undetectable		 3pwrB-4lomA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Mycobacterium
tuberculosis) 		3 / 3 HIS A 126
SER A 156
GLU A 155
 None
 0.89A 3s8pA-4lomA:
undetectable		 3s8pA-4lomA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_B_ROCB801_1
(PROTEASE)		 4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 165
GLY A  84
ALA A 161
VAL A 116
ILE A 163
 None
 0.85A 3tkgA-4lomA:
undetectable		 3tkgA-4lomA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_B_ROCB801_2
(PROTEASE)		 4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 165
GLY A  84
ALA A 161
VAL A 116
ILE A 163
 None
 0.89A 3tkgB-4lomA:
undetectable		 3tkgB-4lomA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKW_B_017B401_1
(PROTEASE)		 4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 165
GLY A  84
ALA A 161
VAL A 116
ILE A 163
 None
 0.87A 3tkwA-4lomA:
undetectable		 3tkwA-4lomA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HLA_A_017A200_1
(PROTEASE)		 4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 165
GLY A  84
ALA A 161
VAL A 116
ILE A 163
 None
 0.76A 4hlaA-4lomA:
undetectable		 4hlaA-4lomA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HLA_A_017A200_2
(PROTEASE)		 4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Mycobacterium
tuberculosis) 		5 / 11 LEU A 165
GLY A  84
ALA A 161
VAL A 116
ILE A 163
 None
 0.73A 4hlaB-4lomA:
undetectable		 4hlaB-4lomA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_A_TESA503_1
(CYTOCHROME P450
MONOOXYGENASE)		 4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Mycobacterium
tuberculosis) 		6 / 12 PHE A 104
GLN A 192
ALA A 103
ALA A 115
ALA A 114
LEU A 170
 None
 1.44A 4j6dA-4lomA:
undetectable		 4j6dA-4lomA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_B_TESB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Mycobacterium
tuberculosis) 		6 / 12 PHE A 104
GLN A 192
ALA A 103
ALA A 115
ALA A 114
LEU A 170
 None
 1.46A 4j6dB-4lomA:
undetectable		 4j6dB-4lomA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_A_ASDA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Mycobacterium
tuberculosis) 		6 / 12 PHE A 104
GLN A 192
ALA A 103
ALA A 115
ALA A 114
LEU A 170
 None
 1.47A 4jbtA-4lomA:
undetectable		 4jbtA-4lomA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_B_ASDB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Mycobacterium
tuberculosis) 		6 / 11 PHE A 104
GLN A 192
ALA A 103
ALA A 115
ALA A 114
LEU A 170
 None
 1.47A 4jbtB-4lomA:
undetectable		 4jbtB-4lomA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDR_A_ADNA402_1
(FAD:PROTEIN FMN
TRANSFERASE)		 4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Mycobacterium
tuberculosis) 		6 / 12 LEU A  49
VAL A  38
ASP A  46
GLY A  41
ILE A  24
THR A  75
 None
 1.30A 4xdrA-4lomA:
2.6		 4xdrA-4lomA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_A_MMSA511_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Mycobacterium
tuberculosis) 		4 / 7 HIS A  73
HIS A 152
VAL A 153
SER A 156
 MN  A 302 ( 3.4A)
MN  A 302 (-3.4A)
None
None
 1.03A 5m8rA-4lomA:
undetectable		 5m8rA-4lomA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Mycobacterium
tuberculosis) 		6 / 12 GLY A  84
TYR A 183
LEU A  49
VAL A  62
ILE A  26
LEU A 165
 None
 1.33A 5ycnA-4lomA:
undetectable		 5ycnA-4lomA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_0
(PROTEASE)		 4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 165
GLY A  84
ALA A 161
VAL A 116
ILE A 163
 None
 0.93A 6dgxA-4lomA:
undetectable		 6dgxA-4lomA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH6_A_017A104_0
(PROTEASE)		 4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 165
GLY A  84
ALA A 161
VAL A 116
ILE A 163
 None
 0.96A 6dh6A-4lomA:
undetectable		 6dh6A-4lomA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIF_B_TPVB201_1
(HIV-1 PROTEASE)		 4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 165
GLY A  84
ALA A 161
VAL A 116
ILE A 163
 None
 0.86A 6difB-4lomA:
undetectable		 6difB-4lomA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6I_A_8PRA509_1
(ENVELOPE
GLYCOPROTEIN,GP,GP1
ENVELOPE
GLYCOPROTEIN)		 4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 194
LEU A  91
GLU A 195
ALA A 193
LEU A  87
 None
 1.09A 6f6iA-4lomA:
undetectable
6f6iB-4lomA:
undetectable		 6f6iA-4lomA:
19.89
6f6iB-4lomA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_C_PCFC607_0
(CYTOCHROME B)		 4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Mycobacterium
tuberculosis) 		5 / 10 PHE A 104
ALA A 185
TYR A 183
PHE A 154
VAL A 167
 None
 1.20A 6hu9C-4lomA:
undetectable		 6hu9C-4lomA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_N_PCFN606_0
(CYTOCHROME B)		 4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Mycobacterium
tuberculosis) 		5 / 12 PHE A 104
ALA A 185
TYR A 183
PHE A 154
VAL A 167
 None
 1.24A 6hu9N-4lomA:
undetectable		 6hu9N-4lomA:
20.88