SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lot'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH614_0
(NADH DEHYDROGENASE,
PUTATIVE)		 4lot COMPLEMENT C1S
SUBCOMPONENT HEAVY
CHAIN
(Homo
sapiens) 		4 / 6 ILE A 304
TYR A 323
VAL A 302
SER A 333
 None
 0.96A 5jwaH-4lotA:
undetectable		 5jwaH-4lotA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEO_A_CYZA1302_1
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA)		 4lot COMPLEMENT C1S
SUBCOMPONENT HEAVY
CHAIN
(Homo
sapiens) 		5 / 10 PRO A 358
SER A 365
ILE A 346
PRO A 347
GLY A 345
 None
 1.12A 5weoA-4lotA:
undetectable
5weoD-4lotA:
undetectable		 5weoA-4lotA:
13.47
5weoD-4lotA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEO_B_CYZB1302_1
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA)		 4lot COMPLEMENT C1S
SUBCOMPONENT HEAVY
CHAIN
(Homo
sapiens) 		5 / 9 PRO A 358
SER A 365
ILE A 346
PRO A 347
GLY A 345
 None
 1.11A 5weoB-4lotA:
undetectable
5weoC-4lotA:
undetectable		 5weoB-4lotA:
13.47
5weoC-4lotA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEO_D_CYZD1302_1
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA)		 4lot COMPLEMENT C1S
SUBCOMPONENT HEAVY
CHAIN
(Homo
sapiens) 		5 / 9 ILE A 346
PRO A 347
GLY A 345
PRO A 358
SER A 365
 None
 1.12A 5weoA-4lotA:
undetectable
5weoD-4lotA:
undetectable		 5weoA-4lotA:
13.47
5weoD-4lotA:
13.47