SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lp2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4001_1
(SERUM ALBUMIN)		 4lp2 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CYSB
(Salmonella
enterica) 		5 / 9 ILE B 259
LEU B 207
VAL B 240
GLY B 241
LEU B 189
 None
 1.16A 1e7aB-4lp2B:
undetectable		 1e7aB-4lp2B:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_H_BEZH515_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4lp2 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CYSB
(Salmonella
enterica) 		4 / 6 PHE B 201
ALA B 151
ILE B 134
PRO B 131
 None
 1.22A 1oniH-4lp2B:
undetectable
1oniI-4lp2B:
undetectable		 1oniH-4lp2B:
22.18
1oniI-4lp2B:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		 4lp2 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CYSB
(Salmonella
enterica) 		4 / 6 ILE B 134
ALA B 148
THR B 270
ALA B 107
 None
 0.95A 1w0gA-4lp2B:
undetectable		 1w0gA-4lp2B:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4lp2 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CYSB
(Salmonella
enterica) 		5 / 12 LEU B 124
LEU B  95
ILE B 112
LEU B 161
VAL B 159
 None
 1.07A 2pnjA-4lp2B:
undetectable		 2pnjA-4lp2B:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_B_DAHB2_1
(RANASMURFIN)		 4lp2 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CYSB
(Salmonella
enterica) 		4 / 8 SER B 268
GLY B 203
SER B 245
ALA B 244
 None
 0.75A 2vh3B-4lp2B:
undetectable		 2vh3B-4lp2B:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_B_TA1B502_1
(TUBULIN BETA CHAIN)		 4lp2 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CYSB
(Salmonella
enterica) 		5 / 10 ASP B 260
LEU B 207
THR B 202
GLN B 103
ARG B 258
 None
 1.43A 3j6gB-4lp2B:
undetectable		 3j6gB-4lp2B:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_D_TA1D502_1
(TUBULIN BETA CHAIN)		 4lp2 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CYSB
(Salmonella
enterica) 		5 / 10 ASP B 260
LEU B 207
THR B 202
GLN B 103
ARG B 258
 None
 1.43A 3j6gD-4lp2B:
undetectable		 3j6gD-4lp2B:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_F_TA1F502_1
(TUBULIN BETA CHAIN)		 4lp2 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CYSB
(Salmonella
enterica) 		5 / 10 ASP B 260
LEU B 207
THR B 202
GLN B 103
ARG B 258
 None
 1.43A 3j6gF-4lp2B:
undetectable		 3j6gF-4lp2B:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_H_TA1H502_1
(TUBULIN BETA CHAIN)		 4lp2 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CYSB
(Salmonella
enterica) 		5 / 10 ASP B 260
LEU B 207
THR B 202
GLN B 103
ARG B 258
 None
 1.43A 3j6gH-4lp2B:
0.5		 3j6gH-4lp2B:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_J_TA1J502_1
(TUBULIN BETA CHAIN)		 4lp2 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CYSB
(Salmonella
enterica) 		5 / 10 ASP B 260
LEU B 207
THR B 202
GLN B 103
ARG B 258
 None
 1.43A 3j6gJ-4lp2B:
undetectable		 3j6gJ-4lp2B:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_L_TA1L502_1
(TUBULIN BETA CHAIN)		 4lp2 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CYSB
(Salmonella
enterica) 		5 / 10 ASP B 260
LEU B 207
THR B 202
GLN B 103
ARG B 258
 None
 1.43A 3j6gL-4lp2B:
undetectable		 3j6gL-4lp2B:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_N_TA1N502_1
(TUBULIN BETA CHAIN)		 4lp2 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CYSB
(Salmonella
enterica) 		5 / 10 ASP B 260
LEU B 207
THR B 202
GLN B 103
ARG B 258
 None
 1.43A 3j6gN-4lp2B:
undetectable		 3j6gN-4lp2B:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_P_TA1P502_1
(TUBULIN BETA CHAIN)		 4lp2 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CYSB
(Salmonella
enterica) 		5 / 10 ASP B 260
LEU B 207
THR B 202
GLN B 103
ARG B 258
 None
 1.43A 3j6gP-4lp2B:
undetectable		 3j6gP-4lp2B:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_R_TA1R502_1
(TUBULIN BETA CHAIN)		 4lp2 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CYSB
(Salmonella
enterica) 		5 / 10 ASP B 260
LEU B 207
THR B 202
GLN B 103
ARG B 258
 None
 1.43A 3j6gR-4lp2B:
undetectable		 3j6gR-4lp2B:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1N_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4lp2 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CYSB
(Salmonella
enterica) 		5 / 11 ILE B 272
ALA B 148
LEU B 108
LEU B  95
THR B 270
 None
 1.25A 4i1nA-4lp2B:
undetectable		 4i1nA-4lp2B:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4lp2 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CYSB
(Salmonella
enterica) 		4 / 6 VAL B 171
SER B 169
ILE B 264
PHE B 265
 None
 1.03A 5jw1B-4lp2B:
undetectable		 5jw1B-4lp2B:
16.28