SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lpq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB2_0
(ACTINOMYCIN D)		 4lpq ERFK/YBIS/YCFS/YNHG
FAMILY PROTEIN
(Xylanimonas
cellulosilytica) 		3 / 3 THR A 248
PRO A 250
THR A 249
 None
 0.89A 1a7yB-4lpqA:
undetectable		 1a7yB-4lpqA:
6.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_D_DVAD8_0
(GRAMICIDIN A)		 4lpq ERFK/YBIS/YCFS/YNHG
FAMILY PROTEIN
(Xylanimonas
cellulosilytica) 		3 / 3 TRP A 274
VAL A 285
TRP A 312
 None
 1.40A 1gmkC-4lpqA:
undetectable
1gmkD-4lpqA:
undetectable		 1gmkC-4lpqA:
9.03
1gmkD-4lpqA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF2_0
(7-AMINO-ACTINOMYCIN
D)		 4lpq ERFK/YBIS/YCFS/YNHG
FAMILY PROTEIN
(Xylanimonas
cellulosilytica) 		3 / 3 THR A 248
PRO A 250
THR A 249
 None
 0.86A 1unjF-4lpqA:
undetectable		 1unjF-4lpqA:
6.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_A_ADNA2001_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 4lpq ERFK/YBIS/YCFS/YNHG
FAMILY PROTEIN
(Xylanimonas
cellulosilytica) 		4 / 7 ARG A 226
ALA A 170
PRO A 197
ALA A 174
 None
 0.92A 2ejfA-4lpqA:
undetectable		 2ejfA-4lpqA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_A_ASDA1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4lpq ERFK/YBIS/YCFS/YNHG
FAMILY PROTEIN
(Xylanimonas
cellulosilytica) 		4 / 7 TYR A 151
PHE A 171
ALA A 193
ALA A 175
 None
 0.85A 2vcvA-4lpqA:
undetectable		 2vcvA-4lpqA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_2
(PHOSPHOLIPASE A2)		 4lpq ERFK/YBIS/YCFS/YNHG
FAMILY PROTEIN
(Xylanimonas
cellulosilytica) 		4 / 5 ILE A 291
SER A 231
PRO A 292
PRO A 295
 None
 1.39A 3bjwC-4lpqA:
undetectable		 3bjwC-4lpqA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_C_CGEC501_1
(CYTOCHROME P450 2B4)		 4lpq ERFK/YBIS/YCFS/YNHG
FAMILY PROTEIN
(Xylanimonas
cellulosilytica) 		5 / 9 VAL A 207
ILE A 209
PHE A 279
ALA A 284
VAL A 303
 None
 1.21A 3me6C-4lpqA:
undetectable		 3me6C-4lpqA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4lpq ERFK/YBIS/YCFS/YNHG
FAMILY PROTEIN
(Xylanimonas
cellulosilytica) 		4 / 5 GLY A 176
TYR A 151
TYR A 195
GLY A 194
 None
 0.96A 5ayfA-4lpqA:
undetectable		 5ayfA-4lpqA:
22.76