SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lps'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1AJ6_A_NOVA1_1 (GYRASE)	4lps	HYDROGENASE/UREASE NICKEL INCORPORATION PROTEIN HYPB (Helicobacter pylori)	5 / 9	ASN A 136 ILE A 100 ALA A 116 ILE A 113 THR A 102	None	1.37A	1aj6A-4lpsA: undetectable	1aj6A-4lpsA: 23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SV5_A_65BA600_0 (REVERSE TRANSCRIPTASE)	4lps	HYDROGENASE/UREASE NICKEL INCORPORATION PROTEIN HYPB (Helicobacter pylori)	5 / 10	LEU A 204 LYS A 205 VAL A 197 VAL A 179 LEU A 167	None MLI A 309 (-3.3A) None None None	1.46A	1sv5A-4lpsA: undetectable	1sv5A-4lpsA: 18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3L2V_A_RLTA397_1 (INTEGRASE)	4lps	HYDROGENASE/UREASE NICKEL INCORPORATION PROTEIN HYPB (Helicobacter pylori)	4 / 7	ASP A 86 ASP A 80 GLN A 82 GLU A 78	MG A 301 ( 2.5A) PO4 A 303 (-3.8A) None MG A 301 ( 4.8A)	1.13A	3l2vA-4lpsA: undetectable	3l2vA-4lpsA: 19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4X1K_D_LOCD502_1 (TUBULIN ALPHA CHAIN TUBULIN BETA CHAIN)	4lps	HYDROGENASE/UREASE NICKEL INCORPORATION PROTEIN HYPB (Helicobacter pylori)	4 / 4	ASN A 50 SER A 238 ALA A 150 VAL A 48	None MLI A 309 ( 4.2A) None None	1.27A	4x1kC-4lpsA: 3.2	4x1kC-4lpsA: 19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NM5_B_LOCB502_1 (TUBULIN ALPHA-1B CHAIN TUBULIN BETA-2B CHAIN)	4lps	HYDROGENASE/UREASE NICKEL INCORPORATION PROTEIN HYPB (Helicobacter pylori)	4 / 4	ASN A 50 SER A 238 ALA A 150 VAL A 48	None MLI A 309 ( 4.2A) None None	1.20A	5nm5A-4lpsA: undetectable	5nm5A-4lpsA: 19.61

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1AJ6_A_NOVA1_1","GYRASE","4lps","HYDROGENASE\/UREASE NICKEL INCORPORATION PROTEIN HYPB","Helicobacter pylori",5,"ASN A 136;ILE A 100;ALA A 116;ILE A 113;THR A 102","None","1.37A","1aj6A-4lpsA:undetectable","1aj6A-4lpsA:23.79"],["1SV5_A_65BA600_0","REVERSE TRANSCRIPTASE","4lps","HYDROGENASE\/UREASE NICKEL INCORPORATION PROTEIN HYPB","Helicobacter pylori",5,"LEU A 204;LYS A 205;VAL A 197;VAL A 179;LEU A 167","None;MLI A 309 (-3.3A);None;None;None","1.46A","1sv5A-4lpsA:undetectable","1sv5A-4lpsA:18.18"],["3L2V_A_RLTA397_1","INTEGRASE","4lps","HYDROGENASE\/UREASE NICKEL INCORPORATION PROTEIN HYPB","Helicobacter pylori",4,"ASP A  86;ASP A  80;GLN A  82;GLU A  78"," MG A 301 ( 2.5A);PO4 A 303 (-3.8A);None; MG A 301 ( 4.8A)","1.13A","3l2vA-4lpsA:undetectable","3l2vA-4lpsA:19.79"],["4X1K_D_LOCD502_1","TUBULIN ALPHA CHAIN;TUBULIN BETA CHAIN","4lps","HYDROGENASE\/UREASE NICKEL INCORPORATION PROTEIN HYPB","Helicobacter pylori",4,"ASN A  50;SER A 238;ALA A 150;VAL A  48","None;MLI A 309 ( 4.2A);None;None","1.27A","4x1kC-4lpsA:3.2","4x1kC-4lpsA:19.83"],["5NM5_B_LOCB502_1","TUBULIN ALPHA-1B CHAIN;TUBULIN BETA-2B CHAIN","4lps","HYDROGENASE\/UREASE NICKEL INCORPORATION PROTEIN HYPB","Helicobacter pylori",4,"ASN A  50;SER A 238;ALA A 150;VAL A  48","None;MLI A 309 ( 4.2A);None;None","1.20A","5nm5A-4lpsA:undetectable","5nm5A-4lpsA:19.61"]]