SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lq0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4lq0 LAGLIDADG HOMING
ENDONUCLEASE
(Leptographium
truncatum) 		5 / 12 LEU A 102
ASP A  20
ASP A 212
LEU A 169
GLY A 165
 None
 1.43A 1d4fB-4lq0A:
undetectable		 1d4fB-4lq0A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_2
(POL POLYPROTEIN)		 4lq0 LAGLIDADG HOMING
ENDONUCLEASE
(Leptographium
truncatum) 		5 / 10 ASP A  53
GLY A 262
ILE A  60
ILE A  15
GLY A 176
 None
 1.07A 1sh9B-4lq0A:
undetectable		 1sh9B-4lq0A:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_1
(MINERALOCORTICOID
RECEPTOR)		 4lq0 LAGLIDADG HOMING
ENDONUCLEASE
(Leptographium
truncatum) 		5 / 12 LEU A  11
ALA A 175
LEU A 265
LEU A  56
THR A  63
 None
 1.34A 1ya3B-4lq0A:
undetectable		 1ya3B-4lq0A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_1
(PROTEASE)		 4lq0 LAGLIDADG HOMING
ENDONUCLEASE
(Leptographium
truncatum) 		5 / 11 ASP A  53
GLY A 262
ILE A  15
GLY A 176
ILE A 178
 None
 0.93A 2nnpA-4lq0A:
undetectable		 2nnpA-4lq0A:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_C_SNLC3001_1
(MINERALOCORTICOID
RECEPTOR)		 4lq0 LAGLIDADG HOMING
ENDONUCLEASE
(Leptographium
truncatum) 		5 / 12 LEU A  11
ALA A 175
LEU A 265
LEU A  56
THR A  63
 None
 1.36A 2oaxC-4lq0A:
undetectable		 2oaxC-4lq0A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_3
(PHOSPHOLIPASE A2)		 4lq0 LAGLIDADG HOMING
ENDONUCLEASE
(Leptographium
truncatum) 		4 / 5 VAL A  41
VAL A  29
THR A 127
THR A  43
 None
 1.27A 3bjwG-4lq0A:
undetectable		 3bjwG-4lq0A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_2
(PROTEASE)		 4lq0 LAGLIDADG HOMING
ENDONUCLEASE
(Leptographium
truncatum) 		5 / 10 ASP A  53
GLY A 262
ILE A  15
GLY A 176
ILE A 178
 None
 0.93A 3el9B-4lq0A:
undetectable		 3el9B-4lq0A:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_K_DHIK3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 4lq0 LAGLIDADG HOMING
ENDONUCLEASE
(Leptographium
truncatum) 		3 / 3 LEU A 102
TRP A 173
GLY A 176
 None
 0.79A 3l35B-4lq0A:
undetectable
3l35K-4lq0A:
undetectable		 3l35B-4lq0A:
9.83
3l35K-4lq0A:
5.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4lq0 LAGLIDADG HOMING
ENDONUCLEASE
(Leptographium
truncatum) 		4 / 8 LEU A 135
VAL A  41
TYR A  39
LEU A 145
 None
 1.09A 3v81A-4lq0A:
undetectable		 3v81A-4lq0A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4lq0 LAGLIDADG HOMING
ENDONUCLEASE
(Leptographium
truncatum) 		4 / 8 PHE A  96
ILE A  60
PHE A  97
GLY A  17
 None
 0.85A 4fgjA-4lq0A:
undetectable
4fgjB-4lq0A:
undetectable		 4fgjA-4lq0A:
23.47
4fgjB-4lq0A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 4lq0 LAGLIDADG HOMING
ENDONUCLEASE
(Leptographium
truncatum) 		5 / 11 GLY A  17
GLY A 176
ALA A  21
LEU A  18
GLU A  22
 None
None
CA  A 402 (-4.9A)
None
CA  A 403 ( 2.8A)
 1.16A 4l8fB-4lq0A:
undetectable		 4l8fB-4lq0A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_F_PARF500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 4lq0 LAGLIDADG HOMING
ENDONUCLEASE
(Leptographium
truncatum) 		5 / 11 PHE A 110
GLU A 181
GLU A 179
ASP A 212
GLY A  17
 None
CA  A 403 ( 2.9A)
None
None
None
 1.36A 4qb9F-4lq0A:
undetectable		 4qb9F-4lq0A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4lq0 LAGLIDADG HOMING
ENDONUCLEASE
(Leptographium
truncatum) 		3 / 3 MET A 277
ASP A 270
PHE A 184
 None
 1.07A 4xeyA-4lq0A:
0.0		 4xeyA-4lq0A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVC_A_BEZA301_0
(DIGUANYLATE CYCLASE
DOSC)		 4lq0 LAGLIDADG HOMING
ENDONUCLEASE
(Leptographium
truncatum) 		4 / 8 ILE A  15
ILE A  60
LEU A  56
LEU A  47
 None
 0.64A 4zvcA-4lq0A:
2.3
4zvcB-4lq0A:
2.3		 4zvcA-4lq0A:
16.23
4zvcB-4lq0A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVC_A_BEZA301_0
(DIGUANYLATE CYCLASE
DOSC)		 4lq0 LAGLIDADG HOMING
ENDONUCLEASE
(Leptographium
truncatum) 		4 / 8 ILE A  60
LEU A  56
LEU A  47
ILE A  15
 None
 0.65A 4zvcA-4lq0A:
2.3
4zvcB-4lq0A:
2.3		 4zvcA-4lq0A:
16.23
4zvcB-4lq0A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_0
(REGULATORY PROTEIN
TETR)		 4lq0 LAGLIDADG HOMING
ENDONUCLEASE
(Leptographium
truncatum) 		5 / 12 MET A  49
ALA A  21
LEU A  47
ILE A  60
PHE A  96
 None
CA  A 402 (-4.9A)
None
None
None
 1.26A 5vlmA-4lq0A:
2.2		 5vlmA-4lq0A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_1
(-)		 4lq0 LAGLIDADG HOMING
ENDONUCLEASE
(Leptographium
truncatum) 		5 / 12 LEU A 102
ASP A  20
ASP A 212
LEU A 169
GLY A 165
 None
 1.49A 6gbnB-4lq0A:
undetectable		 6gbnB-4lq0A:
19.73