SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lq6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA140_0
(LYSOZYME C)		 4lq6 N-ACETYMURAMYL-L-ALA
NINE AMIDASE-RELATED
PROTEIN
(Mycobacterium
tuberculosis) 		3 / 3 ASN A 166
ALA A  86
ASN A  90
 None
 0.75A 1n4fA-4lq6A:
undetectable		 1n4fA-4lq6A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)		 4lq6 N-ACETYMURAMYL-L-ALA
NINE AMIDASE-RELATED
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 11 ALA A  35
HIS A 101
GLY A  10
HIS A  11
GLY A  79
 None
ZN  A 301 (-3.1A)
None
ZN  A 301 (-3.2A)
None
 1.02A 2x1lA-4lq6A:
2.7		 2x1lA-4lq6A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 4lq6 N-ACETYMURAMYL-L-ALA
NINE AMIDASE-RELATED
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 ALA A  35
HIS A 101
GLY A  10
HIS A  11
GLY A  79
 None
ZN  A 301 (-3.1A)
None
ZN  A 301 (-3.2A)
None
 1.05A 2x1lB-4lq6A:
2.7		 2x1lB-4lq6A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)		 4lq6 N-ACETYMURAMYL-L-ALA
NINE AMIDASE-RELATED
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 11 ALA A  35
HIS A 101
GLY A  10
HIS A  11
GLY A  79
 None
ZN  A 301 (-3.1A)
None
ZN  A 301 (-3.2A)
None
 1.10A 2x1lC-4lq6A:
2.7		 2x1lC-4lq6A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4lq6 N-ACETYMURAMYL-L-ALA
NINE AMIDASE-RELATED
PROTEIN
(Mycobacterium
tuberculosis) 		4 / 7 ILE A 145
ILE A 173
LEU A 188
LEU A  57
 None
 0.96A 3adxA-4lq6A:
undetectable		 3adxA-4lq6A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		 4lq6 N-ACETYMURAMYL-L-ALA
NINE AMIDASE-RELATED
PROTEIN
(Mycobacterium
tuberculosis) 		4 / 8 LEU A 210
ALA A  60
LEU A  61
GLN A 139
 None
 0.92A 3cldB-4lq6A:
undetectable		 3cldB-4lq6A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUG_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4lq6 N-ACETYMURAMYL-L-ALA
NINE AMIDASE-RELATED
PROTEIN
(Mycobacterium
tuberculosis) 		4 / 5 GLN A 213
PHE A 209
TYR A 170
LEU A 202
 None
 1.47A 3sugA-4lq6A:
undetectable		 3sugA-4lq6A:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_A_ACTA1002_0
(ACTIN, ALPHA
SKELETAL MUSCLE
FORMIN-LIKE PROTEIN
3)		 4lq6 N-ACETYMURAMYL-L-ALA
NINE AMIDASE-RELATED
PROTEIN
(Mycobacterium
tuberculosis) 		4 / 5 ARG A  72
THR A  48
GLU A  52
THR A  50
 None
 1.43A 4eahA-4lq6A:
undetectable
4eahE-4lq6A:
undetectable
4eahG-4lq6A:
undetectable		 4eahA-4lq6A:
21.65
4eahE-4lq6A:
21.65
4eahG-4lq6A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_F_BEZF501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 4lq6 N-ACETYMURAMYL-L-ALA
NINE AMIDASE-RELATED
PROTEIN
(Mycobacterium
tuberculosis) 		4 / 8 ASN A 182
ALA A 184
SER A 186
TYR A 198
 None
 1.16A 4ijiF-4lq6A:
undetectable		 4ijiF-4lq6A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZO1_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 4lq6 N-ACETYMURAMYL-L-ALA
NINE AMIDASE-RELATED
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  97
ALA A 168
ARG A  27
LEU A 165
PHE A   6
 None
None
None
None
PT  A 308 (-4.5A)
 1.40A 4zo1X-4lq6A:
undetectable		 4zo1X-4lq6A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_B_SAMB501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 4lq6 N-ACETYMURAMYL-L-ALA
NINE AMIDASE-RELATED
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 140
ILE A 145
GLY A 144
LEU A 202
LEU A  57
 None
 1.19A 5nfjB-4lq6A:
undetectable		 5nfjB-4lq6A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_C_SAMC501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 4lq6 N-ACETYMURAMYL-L-ALA
NINE AMIDASE-RELATED
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 140
ILE A 145
GLY A 144
LEU A 202
LEU A  57
 None
 1.17A 5nfjC-4lq6A:
undetectable		 5nfjC-4lq6A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		 4lq6 N-ACETYMURAMYL-L-ALA
NINE AMIDASE-RELATED
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  61
ASN A  62
LEU A  64
GLY A  65
LEU A 210
 None
 1.03A 5uc1B-4lq6A:
undetectable		 5uc1B-4lq6A:
16.09