SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lq8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 4lq8 SCA-FAMILY PROTEIN
(Rickettsia
rickettsii) 		4 / 8 ARG A 328
LYS A 332
ASP A 347
ALA A 351
 None
 0.84A 2rk8A-4lq8A:
undetectable		 2rk8A-4lq8A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_1
(MNMC2)		 4lq8 SCA-FAMILY PROTEIN
(Rickettsia
rickettsii) 		4 / 5 GLU A  49
ASP A  52
ASP A 267
GLU A 218
 None
 1.16A 3vywD-4lq8A:
undetectable		 3vywD-4lq8A:
26.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_C_NCTC501_1
(CYTOCHROME P450 2A13)		 4lq8 SCA-FAMILY PROTEIN
(Rickettsia
rickettsii) 		4 / 7 PHE A 138
PHE A 139
ALA A 151
LEU A 161
 None
 0.85A 4ejgC-4lq8A:
undetectable		 4ejgC-4lq8A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L78_A_ACTA1327_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 4lq8 SCA-FAMILY PROTEIN
(Rickettsia
rickettsii) 		4 / 4 VAL A 221
THR A 220
GLU A 243
GLU A 218
 None
 1.42A 4l78A-4lq8A:
undetectable		 4l78A-4lq8A:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OQR_A_2UOA502_1
(CYP105AS1)		 4lq8 SCA-FAMILY PROTEIN
(Rickettsia
rickettsii) 		5 / 9 PRO A 299
VAL A 262
ILE A 164
ALA A 167
ALA A 276
 None
 1.28A 4oqrA-4lq8A:
undetectable		 4oqrA-4lq8A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_A_1LDA501_0
(CYTOSINE DEAMINASE)		 4lq8 SCA-FAMILY PROTEIN
(Rickettsia
rickettsii) 		5 / 12 LEU A 293
PHE A 279
HIS A 282
GLU A 295
SER A 345
 None
 1.20A 4r88A-4lq8A:
undetectable		 4r88A-4lq8A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_1
(SCRFP-TAG,GP41)		 4lq8 SCA-FAMILY PROTEIN
(Rickettsia
rickettsii) 		5 / 12 GLY A 255
SER A 256
GLU A 337
LEU A 293
GLU A 284
 None
 1.11A 5nwvA-4lq8A:
undetectable		 5nwvA-4lq8A:
7.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YVN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 4lq8 SCA-FAMILY PROTEIN
(Rickettsia
rickettsii) 		4 / 6 GLN A  97
LYS A  98
LEU A 101
LEU A 348
 None
 1.20A 5yvnA-4lq8A:
undetectable		 5yvnA-4lq8A:
20.11