SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lqc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		 4lqc TCPB
(Brucella
melitensis) 		4 / 6 LEU A 196
LEU A 193
ILE A 165
ARG A 162
 None
 1.05A 2rlfA-4lqcA:
undetectable
2rlfB-4lqcA:
undetectable		 2rlfA-4lqcA:
21.43
2rlfB-4lqcA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)		 4lqc TCPB
(Brucella
melitensis) 		4 / 6 LEU A 196
LEU A 193
ILE A 165
ARG A 162
 None
 1.00A 2rlfB-4lqcA:
undetectable
2rlfC-4lqcA:
undetectable		 2rlfB-4lqcA:
21.43
2rlfC-4lqcA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4lqc TCPB
(Brucella
melitensis) 		5 / 12 LEU A 169
THR A 197
SER A 223
PHE A 183
PHE A 184
 None
 1.39A 2y00B-4lqcA:
undetectable		 2y00B-4lqcA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y01_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4lqc TCPB
(Brucella
melitensis) 		5 / 12 LEU A 169
THR A 197
SER A 223
PHE A 183
PHE A 184
 None
 1.38A 2y01B-4lqcA:
undetectable		 2y01B-4lqcA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_E_IPHE101_0
(INSULIN)		 4lqc TCPB
(Brucella
melitensis) 		5 / 11 ILE A 148
LEU A 137
HIS A 247
LEU A 246
ALA A 243
 None
 1.03A 4p65E-4lqcA:
undetectable
4p65F-4lqcA:
undetectable
4p65J-4lqcA:
undetectable
4p65L-4lqcA:
undetectable		 4p65E-4lqcA:
12.50
4p65F-4lqcA:
12.40
4p65J-4lqcA:
12.40
4p65L-4lqcA:
12.40