SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lqx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MXF_B_MTXB2278_1 (PTERIDINE REDUCTASE 2)	4lqx	TENA/THI-4 DOMAIN-CONTAINING PROTEIN (Sulfolobus solfataricus)	5 / 11	ASP A 244 PHE A 236 LEU A 201 THR A 175 TYR A 282	EDO A 414 (-3.8A) None UNL A 402 ( 4.9A) None None	1.27A	1mxfB-4lqxA: undetectable	1mxfB-4lqxA: 22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MXF_C_MTXC3278_1 (PTERIDINE REDUCTASE 2)	4lqx	TENA/THI-4 DOMAIN-CONTAINING PROTEIN (Sulfolobus solfataricus)	5 / 11	ASP A 244 PHE A 236 LEU A 201 THR A 175 TYR A 282	EDO A 414 (-3.8A) None UNL A 402 ( 4.9A) None None	1.27A	1mxfC-4lqxA: undetectable	1mxfC-4lqxA: 22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1QLT_A_ACTA601_0 (VANILLYL-ALCOHOL OXIDASE)	4lqx	TENA/THI-4 DOMAIN-CONTAINING PROTEIN (Sulfolobus solfataricus)	4 / 5	TYR A 282 PHE A 107 TYR A 100 ARG A 286	None UNL A 402 ( 4.2A) UNL A 402 ( 4.5A) UNL A 402 ( 3.1A)	1.29A	1qltA-4lqxA: 0.2	1qltA-4lqxA: 19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1QLT_B_ACTB601_0 (VANILLYL-ALCOHOL OXIDASE)	4lqx	TENA/THI-4 DOMAIN-CONTAINING PROTEIN (Sulfolobus solfataricus)	4 / 5	TYR A 282 PHE A 107 TYR A 100 ARG A 286	None UNL A 402 ( 4.2A) UNL A 402 ( 4.5A) UNL A 402 ( 3.1A)	1.27A	1qltB-4lqxA: 0.5	1qltB-4lqxA: 19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1VAO_A_ACTA601_0 (VANILLYL-ALCOHOL OXIDASE)	4lqx	TENA/THI-4 DOMAIN-CONTAINING PROTEIN (Sulfolobus solfataricus)	4 / 5	TYR A 282 PHE A 107 TYR A 100 ARG A 286	None UNL A 402 ( 4.2A) UNL A 402 ( 4.5A) UNL A 402 ( 3.1A)	1.30A	1vaoA-4lqxA: 0.7	1vaoA-4lqxA: 20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1VAO_B_ACTB601_0 (VANILLYL-ALCOHOL OXIDASE)	4lqx	TENA/THI-4 DOMAIN-CONTAINING PROTEIN (Sulfolobus solfataricus)	4 / 5	TYR A 282 PHE A 107 TYR A 100 ARG A 286	None UNL A 402 ( 4.2A) UNL A 402 ( 4.5A) UNL A 402 ( 3.1A)	1.30A	1vaoB-4lqxA: 0.7	1vaoB-4lqxA: 20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2W98_B_P1ZB1356_1 (PROSTAGLANDIN REDUCTASE 2)	4lqx	TENA/THI-4 DOMAIN-CONTAINING PROTEIN (Sulfolobus solfataricus)	4 / 8	ILE A 86 PHE A 73 TYR A 100 LEU A 209	None None UNL A 402 ( 4.5A) None	0.87A	2w98B-4lqxA: undetectable	2w98B-4lqxA: 21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZE2_A_T27A556_1 (REVERSE TRANSCRIPTASE/RIBONU CLEASE H)	4lqx	TENA/THI-4 DOMAIN-CONTAINING PROTEIN (Sulfolobus solfataricus)	5 / 10	ILE A 223 ASN A 91 TYR A 218 LEU A 97 TYR A 229	None None UNL A 402 ( 4.7A) None None	1.30A	2ze2A-4lqxA: undetectable	2ze2A-4lqxA: 20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EM0_B_CHDB153_0 (ILEAL BILE ACID-BINDING PROTEIN)	4lqx	TENA/THI-4 DOMAIN-CONTAINING PROTEIN (Sulfolobus solfataricus)	4 / 7	ILE A 179 PHE A 279 LYS A 281 TYR A 282	None UNL A 402 ( 4.6A) SO4 A 404 (-3.1A) None	1.02A	3em0B-4lqxA: undetectable	3em0B-4lqxA: 17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HTF_A_ACTA303_0 (S-ADENOSYLMETHIONINE -DEPENDENT METHYLTRANSFERASE)	4lqx	TENA/THI-4 DOMAIN-CONTAINING PROTEIN (Sulfolobus solfataricus)	3 / 3	TYR A 218 HIS A 104 ARG A 286	UNL A 402 ( 4.7A) UNL A 402 ( 4.5A) UNL A 402 ( 3.1A)	1.04A	4htfA-4lqxA: undetectable	4htfA-4lqxA: 23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4M11_C_MXMC606_1 (PROSTAGLANDIN G/H SYNTHASE 2)	4lqx	TENA/THI-4 DOMAIN-CONTAINING PROTEIN (Sulfolobus solfataricus)	5 / 12	TRP A 68 VAL A 268 ALA A 196 SER A 200 LEU A 201	None None None None UNL A 402 ( 4.9A)	1.33A	4m11C-4lqxA: undetectable	4m11C-4lqxA: 20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XMF_A_HSMA202_1 (NITROPHORIN-7)	4lqx	TENA/THI-4 DOMAIN-CONTAINING PROTEIN (Sulfolobus solfataricus)	3 / 3	ASP A 206 LEU A 252 GLY A 249	None	0.51A	4xmfA-4lqxA: undetectable	4xmfA-4lqxA: 19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5N8J_O_DVAO7_0 (GLY-DTY-GLY-DLE-DAL- DSG-DVA-DAS-DGL-DSN- DSN-GLY STREPTAVIDIN)	4lqx	TENA/THI-4 DOMAIN-CONTAINING PROTEIN (Sulfolobus solfataricus)	3 / 3	TYR A 282 SER A 280 TRP A 182	None SO4 A 403 ( 4.4A) None	1.06A	5n8jA-4lqxA: undetectable	5n8jA-4lqxA: 19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5N8J_P_DVAP5_0 (GLY-DTY-GLY-DLE-DAL- DSG-DVA-DAS-DGL-DSN- DSN-GLY STREPTAVIDIN)	4lqx	TENA/THI-4 DOMAIN-CONTAINING PROTEIN (Sulfolobus solfataricus)	3 / 3	TYR A 282 SER A 280 TRP A 182	None SO4 A 403 ( 4.4A) None	1.04A	5n8jD-4lqxA: undetectable	5n8jD-4lqxA: 19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5TOA_B_ESTB601_1 (ESTROGEN RECEPTOR BETA)	4lqx	TENA/THI-4 DOMAIN-CONTAINING PROTEIN (Sulfolobus solfataricus)	5 / 12	MET A 161 LEU A 159 ILE A 102 LEU A 98 LEU A 167	None	1.17A	5toaB-4lqxA: 2.3	5toaB-4lqxA: 23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X6Y_A_SAMA901_0 (MRNA CAPPING ENZYME P5)	4lqx	TENA/THI-4 DOMAIN-CONTAINING PROTEIN (Sulfolobus solfataricus)	6 / 11	VAL A 96 GLY A 95 GLU A 294 SER A 296 ALA A 88 LEU A 287	None None None CL A 406 (-3.1A) None None	1.46A	5x6yA-4lqxA: undetectable	5x6yA-4lqxA: 18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X6Y_C_SAMC901_0 (MRNA CAPPING ENZYME P5)	4lqx	TENA/THI-4 DOMAIN-CONTAINING PROTEIN (Sulfolobus solfataricus)	6 / 11	VAL A 96 GLY A 95 GLU A 294 SER A 296 ALA A 88 LEU A 287	None None None CL A 406 (-3.1A) None None	1.46A	5x6yC-4lqxA: undetectable	5x6yC-4lqxA: 18.02

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1MXF_B_MTXB2278_1","PTERIDINE REDUCTASE 2","4lqx","TENA\/THI-4 DOMAIN-CONTAINING PROTEIN","Sulfolobus solfataricus",5,"ASP A 244;PHE A 236;LEU A 201;THR A 175;TYR A 282","EDO A 414 (-3.8A);None;UNL A 402 ( 4.9A);None;None","1.27A","1mxfB-4lqxA:undetectable","1mxfB-4lqxA:22.00"],["1MXF_C_MTXC3278_1","PTERIDINE REDUCTASE 2","4lqx","TENA\/THI-4 DOMAIN-CONTAINING PROTEIN","Sulfolobus solfataricus",5,"ASP A 244;PHE A 236;LEU A 201;THR A 175;TYR A 282","EDO A 414 (-3.8A);None;UNL A 402 ( 4.9A);None;None","1.27A","1mxfC-4lqxA:undetectable","1mxfC-4lqxA:22.00"],["1QLT_A_ACTA601_0","VANILLYL-ALCOHOL OXIDASE","4lqx","TENA\/THI-4 DOMAIN-CONTAINING PROTEIN","Sulfolobus solfataricus",4,"TYR A 282;PHE A 107;TYR A 100;ARG A 286","None;UNL A 402 ( 4.2A);UNL A 402 ( 4.5A);UNL A 402 ( 3.1A)","1.29A","1qltA-4lqxA:0.2","1qltA-4lqxA:19.82"],["1QLT_B_ACTB601_0","VANILLYL-ALCOHOL OXIDASE","4lqx","TENA\/THI-4 DOMAIN-CONTAINING PROTEIN","Sulfolobus solfataricus",4,"TYR A 282;PHE A 107;TYR A 100;ARG A 286","None;UNL A 402 ( 4.2A);UNL A 402 ( 4.5A);UNL A 402 ( 3.1A)","1.27A","1qltB-4lqxA:0.5","1qltB-4lqxA:19.82"],["1VAO_A_ACTA601_0","VANILLYL-ALCOHOL OXIDASE","4lqx","TENA\/THI-4 DOMAIN-CONTAINING PROTEIN","Sulfolobus solfataricus",4,"TYR A 282;PHE A 107;TYR A 100;ARG A 286","None;UNL A 402 ( 4.2A);UNL A 402 ( 4.5A);UNL A 402 ( 3.1A)","1.30A","1vaoA-4lqxA:0.7","1vaoA-4lqxA:20.25"],["1VAO_B_ACTB601_0","VANILLYL-ALCOHOL OXIDASE","4lqx","TENA\/THI-4 DOMAIN-CONTAINING PROTEIN","Sulfolobus solfataricus",4,"TYR A 282;PHE A 107;TYR A 100;ARG A 286","None;UNL A 402 ( 4.2A);UNL A 402 ( 4.5A);UNL A 402 ( 3.1A)","1.30A","1vaoB-4lqxA:0.7","1vaoB-4lqxA:20.25"],["2W98_B_P1ZB1356_1","PROSTAGLANDIN REDUCTASE 2","4lqx","TENA\/THI-4 DOMAIN-CONTAINING PROTEIN","Sulfolobus solfataricus",4,"ILE A  86;PHE A  73;TYR A 100;LEU A 209","None;None;UNL A 402 ( 4.5A);None","0.87A","2w98B-4lqxA:undetectable","2w98B-4lqxA:21.17"],["2ZE2_A_T27A556_1","REVERSE TRANSCRIPTASE\/RIBONUCLEASE H","4lqx","TENA\/THI-4 DOMAIN-CONTAINING PROTEIN","Sulfolobus solfataricus",5,"ILE A 223;ASN A  91;TYR A 218;LEU A  97;TYR A 229","None;None;UNL A 402 ( 4.7A);None;None","1.30A","2ze2A-4lqxA:undetectable","2ze2A-4lqxA:20.86"],["3EM0_B_CHDB153_0","ILEAL BILE ACID-BINDING PROTEIN","4lqx","TENA\/THI-4 DOMAIN-CONTAINING PROTEIN","Sulfolobus solfataricus",4,"ILE A 179;PHE A 279;LYS A 281;TYR A 282","None;UNL A 402 ( 4.6A);SO4 A 404 (-3.1A);None","1.02A","3em0B-4lqxA:undetectable","3em0B-4lqxA:17.34"],["4HTF_A_ACTA303_0","S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE","4lqx","TENA\/THI-4 DOMAIN-CONTAINING PROTEIN","Sulfolobus solfataricus",3,"TYR A 218;HIS A 104;ARG A 286","UNL A 402 ( 4.7A);UNL A 402 ( 4.5A);UNL A 402 ( 3.1A)","1.04A","4htfA-4lqxA:undetectable","4htfA-4lqxA:23.78"],["4M11_C_MXMC606_1","PROSTAGLANDIN G\/H SYNTHASE 2","4lqx","TENA\/THI-4 DOMAIN-CONTAINING PROTEIN","Sulfolobus solfataricus",5,"TRP A  68;VAL A 268;ALA A 196;SER A 200;LEU A 201","None;None;None;None;UNL A 402 ( 4.9A)","1.33A","4m11C-4lqxA:undetectable","4m11C-4lqxA:20.83"],["4XMF_A_HSMA202_1","NITROPHORIN-7","4lqx","TENA\/THI-4 DOMAIN-CONTAINING PROTEIN","Sulfolobus solfataricus",3,"ASP A 206;LEU A 252;GLY A 249","None","0.51A","4xmfA-4lqxA:undetectable","4xmfA-4lqxA:19.21"],["5N8J_O_DVAO7_0","GLY-DTY-GLY-DLE-DAL-DSG-DVA-DAS-DGL-DSN-DSN-GLY;STREPTAVIDIN","4lqx","TENA\/THI-4 DOMAIN-CONTAINING PROTEIN","Sulfolobus solfataricus",3,"TYR A 282;SER A 280;TRP A 182","None;SO4 A 403 ( 4.4A);None","1.06A","5n8jA-4lqxA:undetectable","5n8jA-4lqxA:19.57"],["5N8J_P_DVAP5_0","GLY-DTY-GLY-DLE-DAL-DSG-DVA-DAS-DGL-DSN-DSN-GLY;STREPTAVIDIN","4lqx","TENA\/THI-4 DOMAIN-CONTAINING PROTEIN","Sulfolobus solfataricus",3,"TYR A 282;SER A 280;TRP A 182","None;SO4 A 403 ( 4.4A);None","1.04A","5n8jD-4lqxA:undetectable","5n8jD-4lqxA:19.57"],["5TOA_B_ESTB601_1","ESTROGEN RECEPTOR BETA","4lqx","TENA\/THI-4 DOMAIN-CONTAINING PROTEIN","Sulfolobus solfataricus",5,"MET A 161;LEU A 159;ILE A 102;LEU A  98;LEU A 167","None","1.17A","5toaB-4lqxA:2.3","5toaB-4lqxA:23.58"],["5X6Y_A_SAMA901_0","MRNA CAPPING ENZYME P5","4lqx","TENA\/THI-4 DOMAIN-CONTAINING PROTEIN","Sulfolobus solfataricus",6,"VAL A  96;GLY A  95;GLU A 294;SER A 296;ALA A  88;LEU A 287","None;None;None; CL A 406 (-3.1A);None;None","1.46A","5x6yA-4lqxA:undetectable","5x6yA-4lqxA:18.02"],["5X6Y_C_SAMC901_0","MRNA CAPPING ENZYME P5","4lqx","TENA\/THI-4 DOMAIN-CONTAINING PROTEIN","Sulfolobus solfataricus",6,"VAL A  96;GLY A  95;GLU A 294;SER A 296;ALA A  88;LEU A 287","None;None;None; CL A 406 (-3.1A);None;None","1.46A","5x6yC-4lqxA:undetectable","5x6yC-4lqxA:18.02"]]