SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lr2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		 4lr2 BIS(5'-ADENOSYL)-TRI
PHOSPHATASE ENPP4
(Homo
sapiens) 		5 / 5 THR A  70
ASP A 189
HIS A 193
HIS A 238
HIS A 336
 ZN  A 505 ( 2.4A)
ZN  A 506 ( 2.1A)
ZN  A 506 ( 3.3A)
ZN  A 505 (-3.1A)
ZN  A 506 ( 3.3A)
 0.44A 1ei6A-4lr2A:
7.7		 1ei6A-4lr2A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		 4lr2 BIS(5'-ADENOSYL)-TRI
PHOSPHATASE ENPP4
(Homo
sapiens) 		6 / 8 ASP A  34
THR A  70
ASP A 189
HIS A 193
HIS A 238
HIS A 336
 ZN  A 505 (-2.1A)
ZN  A 505 ( 2.4A)
ZN  A 506 ( 2.1A)
ZN  A 506 ( 3.3A)
ZN  A 505 (-3.1A)
ZN  A 506 ( 3.3A)
 0.44A 1ei6C-4lr2A:
27.8		 1ei6C-4lr2A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		 4lr2 BIS(5'-ADENOSYL)-TRI
PHOSPHATASE ENPP4
(Homo
sapiens) 		4 / 8 THR A  70
ASP A 189
HIS A 193
HIS A 336
 ZN  A 505 ( 2.4A)
ZN  A 506 ( 2.1A)
ZN  A 506 ( 3.3A)
ZN  A 506 ( 3.3A)
 0.44A 1ei6D-4lr2A:
16.4		 1ei6D-4lr2A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ESW_A_ACRA652_1
(AMYLOMALTASE)		 4lr2 BIS(5'-ADENOSYL)-TRI
PHOSPHATASE ENPP4
(Homo
sapiens) 		4 / 6 TYR A 338
GLY A 337
GLY A 334
SER A 266
 None
 0.96A 1eswA-4lr2A:
undetectable		 1eswA-4lr2A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_A_DVAA8_0
(GRAMICIDIN B)		 4lr2 BIS(5'-ADENOSYL)-TRI
PHOSPHATASE ENPP4
(Homo
sapiens) 		4 / 4 GLY A  87
VAL A  89
TRP A 113
TRP A 112
 None
 1.40A 1jo3A-4lr2A:
undetectable		 1jo3A-4lr2A:
6.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_B_DVAB8_0
(GRAMICIDIN B)		 4lr2 BIS(5'-ADENOSYL)-TRI
PHOSPHATASE ENPP4
(Homo
sapiens) 		4 / 4 GLY A  87
VAL A  89
TRP A 113
TRP A 112
 None
 1.40A 1jo3B-4lr2A:
undetectable		 1jo3B-4lr2A:
6.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 4lr2 BIS(5'-ADENOSYL)-TRI
PHOSPHATASE ENPP4
(Homo
sapiens) 		6 / 12 HIS A 193
THR A 241
GLY A 334
GLY A 196
GLY A 192
GLY A 337
 ZN  A 506 ( 3.3A)
None
None
None
None
None
 1.33A 1n2xB-4lr2A:
undetectable		 1n2xB-4lr2A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		 4lr2 BIS(5'-ADENOSYL)-TRI
PHOSPHATASE ENPP4
(Homo
sapiens) 		4 / 6 TYR A 154
GLY A  35
PHE A  33
SER A 236
 None
ZN  A 505 ( 4.8A)
None
None
 1.31A 2a3cA-4lr2A:
undetectable		 2a3cA-4lr2A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DXR_A_SORA1002_0
(LACTOTRANSFERRIN)		 4lr2 BIS(5'-ADENOSYL)-TRI
PHOSPHATASE ENPP4
(Homo
sapiens) 		3 / 3 THR A 122
PRO A 382
TYR A 371
 None
 0.78A 2dxrA-4lr2A:
undetectable		 2dxrA-4lr2A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACHA546_0
(ACETYLCHOLINESTERASE)		 4lr2 BIS(5'-ADENOSYL)-TRI
PHOSPHATASE ENPP4
(Homo
sapiens) 		4 / 8 TYR A 338
TYR A  40
HIS A 193
GLY A 192
 None
None
ZN  A 506 ( 3.3A)
None
 0.99A 2ha4A-4lr2A:
undetectable		 2ha4A-4lr2A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 4lr2 BIS(5'-ADENOSYL)-TRI
PHOSPHATASE ENPP4
(Homo
sapiens) 		5 / 12 VAL A  57
ILE A 233
THR A 235
LEU A  30
LEU A 396
 None
 1.21A 2jn3A-4lr2A:
undetectable		 2jn3A-4lr2A:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9G_A_TOPA1159_1
(DIHYDROFOLATE
REDUCTASE)		 4lr2 BIS(5'-ADENOSYL)-TRI
PHOSPHATASE ENPP4
(Homo
sapiens) 		5 / 10 ALA A  90
ASP A 264
VAL A 268
ILE A 299
PHE A  66
 None
 0.94A 2w9gA-4lr2A:
undetectable		 2w9gA-4lr2A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRE_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 4lr2 BIS(5'-ADENOSYL)-TRI
PHOSPHATASE ENPP4
(Homo
sapiens) 		5 / 9 ALA A  90
ASP A 264
VAL A 268
ILE A 299
PHE A  66
 None
 0.93A 3freX-4lr2A:
undetectable		 3freX-4lr2A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_2
(GLUCOCORTICOID
RECEPTOR)		 4lr2 BIS(5'-ADENOSYL)-TRI
PHOSPHATASE ENPP4
(Homo
sapiens) 		3 / 3 MET A 345
CYH A 243
PRO A 267
 None
 1.17A 3h52C-4lr2A:
undetectable		 3h52C-4lr2A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4lr2 BIS(5'-ADENOSYL)-TRI
PHOSPHATASE ENPP4
(Homo
sapiens) 		4 / 4 LEU A  30
MET A 152
ILE A 210
ASP A 189
 None
NAG  A 504 ( 3.8A)
None
ZN  A 506 ( 2.1A)
 1.28A 3hecA-4lr2A:
undetectable		 3hecA-4lr2A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3003_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4lr2 BIS(5'-ADENOSYL)-TRI
PHOSPHATASE ENPP4
(Homo
sapiens) 		4 / 6 ILE A 365
VAL A  62
HIS A 362
LEU A  58
 None
 0.82A 3kp6A-4lr2A:
undetectable
3kp6B-4lr2A:
undetectable		 3kp6A-4lr2A:
19.38
3kp6B-4lr2A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)		 4lr2 BIS(5'-ADENOSYL)-TRI
PHOSPHATASE ENPP4
(Homo
sapiens) 		4 / 8 ILE A 214
GLY A 215
PRO A  47
ASN A  51
 None
 0.94A 3lslA-4lr2A:
undetectable
3lslD-4lr2A:
undetectable		 3lslA-4lr2A:
20.83
3lslD-4lr2A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)		 4lr2 BIS(5'-ADENOSYL)-TRI
PHOSPHATASE ENPP4
(Homo
sapiens) 		4 / 8 PRO A  47
ASN A  51
ILE A 214
GLY A 215
 None
 0.93A 3lslA-4lr2A:
undetectable
3lslD-4lr2A:
undetectable		 3lslA-4lr2A:
20.83
3lslD-4lr2A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		 4lr2 BIS(5'-ADENOSYL)-TRI
PHOSPHATASE ENPP4
(Homo
sapiens) 		4 / 7 THR A  70
ASP A 189
HIS A 193
HIS A 336
 ZN  A 505 ( 2.4A)
ZN  A 506 ( 2.1A)
ZN  A 506 ( 3.3A)
ZN  A 506 ( 3.3A)
 0.41A 3t01A-4lr2A:
27.5		 3t01A-4lr2A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4APJ_A_ACTA1635_0
(ANGIOTENSIN-CONVERTI
NG ENZYME
BRADYKININ-POTENTIAT
ING PEPTIDE B)		 4lr2 BIS(5'-ADENOSYL)-TRI
PHOSPHATASE ENPP4
(Homo
sapiens) 		4 / 6 HIS A 238
ASP A 237
SER A  32
PRO A 188
 ZN  A 505 (-3.1A)
ZN  A 505 (-2.3A)
None
None
 1.31A 4apjA-4lr2A:
undetectable
4apjP-4lr2A:
undetectable		 4apjA-4lr2A:
20.40
4apjP-4lr2A:
4.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		 4lr2 BIS(5'-ADENOSYL)-TRI
PHOSPHATASE ENPP4
(Homo
sapiens) 		5 / 12 ASP A 335
HIS A  74
ASP A  34
HIS A 193
GLY A  35
 None
None
ZN  A 505 (-2.1A)
ZN  A 506 ( 3.3A)
ZN  A 505 ( 4.8A)
 1.46A 4bz6A-4lr2A:
2.1
4bz6B-4lr2A:
undetectable		 4bz6A-4lr2A:
21.12
4bz6B-4lr2A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_C_SVRC301_1
(NUCLEOCAPSID PROTEIN)		 4lr2 BIS(5'-ADENOSYL)-TRI
PHOSPHATASE ENPP4
(Homo
sapiens) 		4 / 8 ASN A 282
LYS A 283
PRO A 273
ILE A 275
 None
 0.90A 4j4vC-4lr2A:
undetectable		 4j4vC-4lr2A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		 4lr2 BIS(5'-ADENOSYL)-TRI
PHOSPHATASE ENPP4
(Homo
sapiens) 		5 / 12 HIS A 336
HIS A 193
GLY A 192
ASP A  34
GLY A  35
 ZN  A 506 ( 3.3A)
ZN  A 506 ( 3.3A)
None
ZN  A 505 (-2.1A)
ZN  A 505 ( 4.8A)
 1.22A 4lxzA-4lr2A:
undetectable		 4lxzA-4lr2A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		 4lr2 BIS(5'-ADENOSYL)-TRI
PHOSPHATASE ENPP4
(Homo
sapiens) 		5 / 12 HIS A 336
HIS A 193
GLY A 192
ASP A  34
GLY A  35
 ZN  A 506 ( 3.3A)
ZN  A 506 ( 3.3A)
None
ZN  A 505 (-2.1A)
ZN  A 505 ( 4.8A)
 1.21A 4lxzC-4lr2A:
undetectable		 4lxzC-4lr2A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2R_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 4lr2 BIS(5'-ADENOSYL)-TRI
PHOSPHATASE ENPP4
(Homo
sapiens) 		4 / 4 HIS A  48
GLU A  55
HIS A 352
LEU A  29
 None
 1.43A 4m2rA-4lr2A:
undetectable		 4m2rA-4lr2A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_A_5D5A930_0
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 4lr2 BIS(5'-ADENOSYL)-TRI
PHOSPHATASE ENPP4
(Homo
sapiens) 		5 / 12 ASP A  34
THR A  70
PHE A  71
PRO A 118
ARG A 163
 ZN  A 505 (-2.1A)
ZN  A 505 ( 2.4A)
None
None
None
 0.64A 5dlvA-4lr2A:
43.0		 5dlvA-4lr2A:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_B_5D5B927_0
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 4lr2 BIS(5'-ADENOSYL)-TRI
PHOSPHATASE ENPP4
(Homo
sapiens) 		6 / 12 ASP A  34
THR A  70
PHE A  71
PRO A 118
TRP A 120
ARG A 163
 ZN  A 505 (-2.1A)
ZN  A 505 ( 2.4A)
None
None
None
None
 0.66A 5dlvB-4lr2A:
43.1		 5dlvB-4lr2A:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HV1_A_RFPA902_1
(PHOSPHOENOLPYRUVATE
SYNTHASE)		 4lr2 BIS(5'-ADENOSYL)-TRI
PHOSPHATASE ENPP4
(Homo
sapiens) 		5 / 12 ALA A 132
VAL A 178
LEU A 378
LEU A 164
ILE A 234
 None
 1.23A 5hv1A-4lr2A:
undetectable		 5hv1A-4lr2A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGP_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4lr2 BIS(5'-ADENOSYL)-TRI
PHOSPHATASE ENPP4
(Homo
sapiens) 		5 / 12 MET A 374
ILE A 370
ALA A 132
ALA A 181
TYR A 184
 None
 1.23A 5igpA-4lr2A:
undetectable		 5igpA-4lr2A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_1
(CYTOCHROME P450 3A5)		 4lr2 BIS(5'-ADENOSYL)-TRI
PHOSPHATASE ENPP4
(Homo
sapiens) 		5 / 12 SER A 236
GLY A 334
ALA A  38
GLU A 187
GLY A 196
 None
 1.04A 5veuH-4lr2A:
undetectable		 5veuH-4lr2A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BC9_A_ETSA302_2
(CARBONIC ANHYDRASE 2)		 4lr2 BIS(5'-ADENOSYL)-TRI
PHOSPHATASE ENPP4
(Homo
sapiens) 		4 / 5 HIS A  48
GLU A  55
HIS A 352
LEU A 226
 None
 1.13A 6bc9A-4lr2A:
undetectable		 6bc9A-4lr2A:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F32_B_ACTB602_0
(AMINE OXIDASE LKCE)		 4lr2 BIS(5'-ADENOSYL)-TRI
PHOSPHATASE ENPP4
(Homo
sapiens) 		4 / 6 ASN A 386
TYR A 304
VAL A 368
VAL A  65
 NAG  A 501 (-1.8A)
NAG  A 501 (-4.3A)
None
None
 1.38A 6f32B-4lr2A:
undetectable		 6f32B-4lr2A:
22.18